The prognostic value of minimal residual disease (MRD) in Philadelphia-chromosome-positive (Ph+) childhood acute lymphoblastic leukemia (ALL) treated with tyrosine kinase inhibitors is not fully established. We detected MRD by real-time quantitative polymerase chain reaction (RQ-PCR) of rearranged immunoglobulin/T-cell receptor genes (IG/TR) and/or BCR/ABL1 fusion transcript to investigate its pre

Measurements of the azimuthal anisotropy in lead–lead collisions at sNN = 5.02 TeV are presented using a data sample corresponding to 0.49 nb - 1 integrated luminosity collected by the ATLAS experiment at the LHC in 2015. The recorded minimum-bias sample is enhanced by triggers for “ultra-central” collisions, providing an opportunity to perform detailed study of flow harmonics in the regime where

A search for new phenomena in events with two same-charge leptons or three leptons and jets identified as originating from b-quarks in a data sample of 36.1 fb−1 of pp collisions at s=13 TeV recorded by the ATLAS detector at the Large Hadron Collider is reported. No significant excess is found and limits are set on vector-like quark, four-top-quark, and same-sign top-quark pair production. The obs

Possible crystal structures of aluminium defects in concrete materials are tested with reactive force filed ReaxFF. The ongoing project includes further refinement of the structures by semiempirical and ab initio methods.

Corrugated tubes are widely used in a range of applications for heat transfer enhancement. The spirally corrugated tube has a better heat transfer performance than the smooth tube. In this paper, the heat transfer performance of a hybrid smooth and six-start spirally corrugated tube is studied. With a validated numerical model, the effects of the corrugation part length on the vortex in the downst

When liquids flowing through a throttling element, such as a perforated plate, the velocity increases and the pressure decreases. If the pressure is below the saturated vapor pressure, the liquid will vaporize into small bubbles, which is called hydraulic cavitation. In fact, vaporization nucleus is another crucial condition for vaporizing. The nanoparticles contained in the nanofluids play a sign

BACKGROUND: Proteomic approaches allow measurement of thousands of proteins in a single specimen, which can accelerate biomarker discovery. However, applying these technologies to massive biobanks is not currently feasible because of the practical barriers and costs of implementing such assays at scale. To overcome these challenges, we used a "virtual proteomic" approach, linking genetically predi

The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin on the substantia nigra (SN), the main structure affected in Parkinson’s disease (PD), has not yet been studied in depth. Inflammation is a key feature of PD and it may play a

Mesopolobus incultus auct. is hypothesized to consist of two different species, M. amyntor (Walker) and M incultus (Walker). This hypothesis is supported by molecular (cytochrome c oxidase subunit I, i.e. COI), morphological and biological data. Mesopolobus amyntor is a primary parasitoid of Mecinus pascuorum (Gyllenhal) and M. labilis (Herbst) (Coleoptera: Curculionidae) on Plantago lanceolata. M

In this paper we address the problem of registering and merging two maps in two dimensions, given covariance estimates of the two maps. We show that if two maps are given in the same coordinate system, then the problem of merging them in a statistically optimal way can be formulated as a linear least squares problem, but if they are given in different coordinate systems as well the problem becomes

An optimal plasmonic resonance is derived for small homogeneous and isotropic inclusions in a lossy surrounding medium. The optimal resonance is given in terms of any particular eigenmode (electrostatic resonance) associated with the double-layer potential for a smooth, but otherwise arbitrary surface.

The European Spallation Source (ESS), presently under construction in Lund, Sweden, is designed to be the world's brightest neutron source. When it will be in operation, ESS will deliver an instantaneous neutron flux on detectors that will be without precedent. A down side of the high brightness will be the increase of background, especially from gamma-rays and fast-neutrons.Considering that scatt

Many studies have been, and are currently, conducted on how virtual agents should be designed and used for training and learning. In this paper we address the question of how such agents are introduced to users in systems and classroom settings, and the possible effect that have on how they are perceived, and the reactions and behavior that they invoke. We specifically investigated a system where

We develop an algorithm for recursively constructing orthogonal multiplet bases for the color space of QCD, for any order of partons and any Nc. This recipe is then applied for explicitly constructing some of these bases. Using the bases, a corresponding set of Wigner 6j coefficients are calculated. The Wigner coefficients offer a method of using multiplet bases without resorting to the explicit e

Concomitant reactions to palladium chloride (PdCl2), sodium tetrachloropalladate (Na2PdCl4), and nickel hexahydrate sulphate (NiSO4·6H2O) are very common during patch testing and have mainly been explained by cross-sensitisation. Whether there is variation in reactivity to palladium or covariation to nickel and palladium is not known. The aim of this study was to investigate the variation in patch

Sensitivity tests were conducted using a state-of-the-art aerosol–cloud to investigate the key microphysical and dynamical mechanisms by which solid aerosols affect glaciated clouds. The tests involved simulations of two contrasting cases of deep convection—a tropical maritime case and a midlatitude continental case, in which solid aerosol concentrations were increased from their pre-industrial (1

Fast directional growth is a necessity for the young seedling; after germination, it needs to quickly penetrate the soil to begin its autotrophic life. In most dicot plants, this rapid escape is due to the anisotropic elongation of the hypocotyl, the columnar organ between the root and the shoot meristems. Anisotropic growth is common in plant organs and is canonically attributed to cell wall anis