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Doctoral theses derived from the Division of Translational Cancer Research (TCR). Click on the title for a direct link to the full electronic copy of the thesis. Immune Response in Triple-Negative Breast Cancer - Machine Learning-based Insights from Histology and -Omics Author: Suze Julia RoosteeMain Supervisor: Johan StaafCo-supervisor: Mattias Ohlsson, Mattias AineOpponent: Raza Ali (Cambridge)D
https://www.tcr.lu.se/doctoral-theses - 2025-11-29
Our locals are situated at Medicon Village in Lund, in the south of Sweden. From Copenhagen Airport to Lund CentralIt is fairly easy getting here from Copenhagen Airport (CPH) via train and a ticket costs around 180 SEK (16 EURO). You can download the Skånetrafiken app for buying tickets easily since you can no longer by tickets on the train.Tutorial on Youtube on how to take the train to LundSkån
https://www.tcr.lu.se/welcome - 2025-11-29
Daniel Bexell Molecular Pediatric Oncology Yvonne Ceder Medical Molecular Biology Christer Larsson Tumor Cell Biology Ramin Massoumi Molecular Tumor Pathology Alexander Pietras Brain Tumor Biology Kristian Pietras Experimental Oncology Charlotte Rolny Immuno-Oncology Group Lars Rönnstrand Molecular Cancer Research Johan Staaf Breast/Lungcancer Kazi Uddin Molecular Cancer Medicine Calendar Link to
https://www.tcr.lu.se/tcr - 2025-11-29
Wild-type chick at Embryonic day E5. Wild-type chick at Embryonic day E9.
https://www.tcr.lu.se/embryo - 2025-11-29
Bexell lab For a complete list of publications, please visit our Lund University Research Portal page (linked on the right hand side).Selected publicationsKarlsson J, Yasui H, Mañas A, Andersson N, Hansson K, Aaltonen K, Jansson C, Durand G, Ravi N, Ferro M, Yang M, Chattopadhyay S, Paulsson K, Spierings D, Foijer F, Valind A, Bexell D, Gisselsson D. (2024) Early evolutionary branching across spat
https://www.tcr.lu.se/research-groups/molecular-pediatric-oncology/publications - 2025-11-29
Team members Matilda Engström MD Dora Adamic PhD student Hanna Chahin MD, PhD student Alexandra Seger PhD student Aleksandra Adamska Post-doc Erick Muciño Olmos Post-doc Joachim Tetteh Siaw Postdoc Chiara Lago Post-doc Kristina Aaltonen Associate researcher Javan Esfandyari Research engineer Caroline Jansson Lab technician Katarina Turesson Research administrator Daniel Bexell Group leader
https://www.tcr.lu.se/research-groups/molecular-pediatric-oncology/bexell-lab - 2025-11-29
The Bexell lab is grateful for the generous funding from: The European Research CouncilThe Swedish Research CouncilThe Swedish Childhood Cancer FoundationThe Swedish Cancer SocietyThe Medical Faculty at Lund UniversityALF goverment fundingThe Crafoord FoundationÅke Wiberg FoundationThe Royal Physiographic Society in LundBerth von Kantzow Foundation Research portal Visit the Molecular Pediatric Onc
https://www.tcr.lu.se/research-groups/molecular-pediatric-oncology/funding-support - 2025-11-29
We are dedicated to help children with cancer and our work is focused on neuroblastoma, a cancer derived from the sympathetic nervous system. Our overall goals are to investigate mechanisms of metastasis and treatment resistance, and to identify and test novel therapies against high-risk neuroblastoma. We have three main aims: 1. DEVELOPMENT OF CLINICALLY RELEVANT CANCER MODELSClinically relevant
https://www.tcr.lu.se/research-groups/molecular-pediatric-oncology/research - 2025-11-29
In excess of our standard lab equipment we have some specialised machines for certain tests or imaging. IVIS-CTIn Vivo Imaging System Spectrum CT 3D The IVIS Spectrum CT enables longitudinal workflows to characterize disease progression and therapeutic effect in animals throughout the complete experimental time frame with both quantitative CT and optical reconstructions. The preclinical models inc
https://www.tcr.lu.se/equipment - 2025-11-29
In Vivo Imaging System Spectrum CT 3D The IVIS Spectrum CT enables longitudinal workflows to characterize disease progression and therapeutic effect in animals throughout the complete experimental time frame with both quantitative CT and optical reconstructions. The preclinical models includes oncology, toxicology, cardiovascular disease, neurological disorders, inflammation and other related dise
https://www.tcr.lu.se/equipment/ivis-ct - 2025-11-29
Preclinical Multispectral Optoacoustic Tomography Multispectral Optoacoustic Tomography is a powerful optoacoustic imaging system for small animal imaging. It acquires cross-sectional images from head to tail, with high resolution, in vivo and in real time. The machine is also equipped with ultrasound computed tomography for further insights. MSOT InVision 512-Echo Image rate: 10/2 fps (MSOT/US) S
https://www.tcr.lu.se/equipment/msot - 2025-11-29
Live Cell Inverted Confocal Microscope The Zeiss 710 confocal laser scanning microscopes scan samples sequentially point by point. The microscope combines high-resolution optical imaging with depth selectivity which allows us to do optical sectioning. The inverted microscope is equipped with motorized stage, heated incubator, controller regulating O2, CO2 and humidity. This allow longitudinal imag
https://www.tcr.lu.se/equipment/zeiss-710 - 2025-11-29
We are continuesly working on the accessibility of this webpage. This document describes how well tcr.lu.se complies with the accessibility regulations, any known accessibility issues, and how you can report problems so that we can fix them. If you experience any issues visiting our site we ask that you please contact us and let us know: johanna.verngren@med.lu.se How accessible is tcr.lu.se?This
https://www.tcr.lu.se/accessibility-report - 2025-11-29
PI Johan Staaf Breast Cancer researchBreast cancer is the most common malignancy in women and a heterogeneous disease at the molecular level. This heterogeneity translates into differences in clinical manifestation, patient therapies, and ultimately patient outcome. TNBC is a subgroup of breast cancer, representing ~10% of all cases (9% in Sweden 2015). To date, this patient subgroup has often had
https://www.tcr.lu.se/research-groups/breastlung-cancer - 2025-11-29
Our task is to understand the basic mechanisms behind tumor development. This understanding provides a basis for matching the right drug with the right patient and thereby offer better conditions for individualized treatment of cancer patients. The Division of Translational Cancer Research (TCR) was founded 2013 in conjunction with the formation of Lund University Cancer Center (LUCC) at Medicon V
https://www.tcr.lu.se/translational-cancer-research - 2025-11-29
PI Yvonne Ceder Our researchProstate cancer is the most common cancer in men in industrialized countries, and the manifestation of distant metastasis is the major cause of cancer-related deaths in these men. Our research aims to deduce the role of post transcriptional regulation in prostate cancer initiation and progression. The current focus of our research is on RNA editing and m6A modification
https://www.tcr.lu.se/research-groups/medical-molecular-biology - 2025-11-29
PI Christer Larsson Our researchOur aims are to identify and understand mechanisms regulating breast cancer cell death and how inflammatory signaling can be induced and influence breast cancer progression. We specifically study Smac mimetics, small molecules mimicking the effect of the pro-apoptotic protein Smac. We investigate determinants of Smac-responsiveness and ways to circumvent resistance
https://www.tcr.lu.se/research-groups/tumor-cell-biology - 2025-11-29
PI Charlotte Rolny ResearchOur research primarily focuses on tumor immunology, with a particular emphasis on understanding the behavior of Tumor-Associated Macrophages (TAMs) and is dedicated to finding novel targets that reprogram immunosuppressive and pro-metastatic Tumor-Associated Macrophages into an anti-tumor phenotype. Our lab employs state-of-the-art molecular biology techniques, mouse mod
https://www.tcr.lu.se/research-groups/immuno-oncology-group - 2025-11-29
Swedish Research Council (VR)Swedish Cancer SocietyWenner-Gren foundationsThe Swedish Childhood Cancer FoundationFru Berta Kamprads stiftelse
https://www.tcr.lu.se/research-groups/immuno-oncology-group/funding - 2025-11-29
VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells.Banerjee K, Kerzel T, Bekkhus T, Ferreira de Souza S, Wallmann T, Wallerius M, Landwehr LS, Agardy DA, Schauer N, Malmerfeldt A, Bergh J, Bartish M, Hartman J, Östman A, Squadrito ML and Rolny C. Cell Reports. 2023 Dec 1;42(12):113507. doi: 10.1016/j.celrep.2023.113507 MNK2 governs the macrophage antiinflammatory phenotype.B
https://www.tcr.lu.se/research-groups/charlotte-rolny/selected-publications - 2025-11-29
