Distant metastasis is the major cause of cancer-related deaths in men with prostate cancer (PCa). An in vivo functional screen was used to identify microRNAs (miRNAs) regulating metastatic dissemination of PCa cells. PC3 cells transduced with pooled miRZiP™ lentivirus library (anti-miRNAs) were injected intraprostatic to 13 NSG mice followed by targeted barcode/anti-miR sequencing. PCa cells in th

Brake wear is known as the primary source of traffic-related non-exhaust particle generation. Its generation rate is influenced by parameters at different levels: subsystem (type of brakes, pads, materials, etc.), system (vehicles' dynamics, driving style etc.) and suprasystem (road geometries, traffic parameters, etc.). At the subsystem level, we proposed a neural network brake emission modeling,

Introduction: Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 (T1D) and type 2 diabetes (T2D). No cure for DPN is available, but several potential targets have been proposed for treatment. Heat shock proteins (HSPs) are known to respond to both hyper- and hypoglycemia. DPN can be diagnosed using electrophysiology and studied using peripheral nerve biopsies.Aim: This st

In this communication we demonstrate the role of turbulence intensity in the dual-front structure and self-similar propagation of spherical turbulent iron-methane hybrid flames. We first show that iron-methane hybrid mixture, whose iron concentration is below a critical threshold for the formation of a dust flame front in laminar or weak turbulent environment, can be burned strongly with both sepa

AimsThe aim is to investigate associations between attendance in religious service during the past year and all-cause, cardiovascular (CVD), cancer and other cause mortality.Study designProspective cohort study.MethodsA public health survey with three reminders was sent to a stratified random sample of the adult 18–80 population in southernmost Sweden in 2008. The response rate was 54.1%, and 24,8

Objectives To assess the impact of the COVID-19 pandemic on sick leave among healthcare workers (HCWs) in primary and specialist care and examine its causes. Methods Using individual-level register data, we studied monthly proportions of sick leave (all-cause and not related to SARS-CoV-2 infection) from 2017 to February 2022 for all HCWs in primary (N=60 973) and specialist care (N=34 978) in Nor

In a future warmer climate, extremely dry, warm summers might become more common. Soil weathering is affected by temperature and precipitation, and climate change and droughts can therefore affect soil chemistry and plant nutrition. In this study, climate change and drought effects on soil weathering rates and release of Ca, Mg, K and Na were studied on seven forest sites across different climates

The COVID-19 pandemic has significantly increased the use of remote services such as video consultations (VCs). In Sweden, private healthcare providers offering VCs have grown substantially since 2016 and have been controversial. Few studies have focused on physicians' experiences of providing care in this context. Our overall aim was to study physicians' experiences of VCs, here focusing on their

Surveys of star-forming regions reveal that the dust mass of protoplanetary discs decreases by several orders of magnitude on timescales of a few million years. This decrease in the mass budget of solids is likely due to the radial drift of millimetre (mm) sized solids, called pebbles, induced by gas drag. However, quantifying the evolution of this dust component in young stellar clusters is diffi

Extracellular matrix (ECM) remodeling has been associated with chronic lung diseases. However, information about specific age-associated differences in lung ECM is currently limited. In this study, we aimed to identify and localize age-associated ECM differences in human lungs using comprehensive transcriptomic, proteomic, and immunohistochemical analyses. Our previously identified age-associated

Objective High vitreous levels of soluble (s)CD163 have been demonstrated in severe diabetic retinopathy (DR). The aim of this study was to explore the predictive values of plasma sCD163 and glycated haemoglobin (HbA1c) for DR progression in adults with type 1 diabetes. Methods and analyses The study design was prospective. Fundus photography performed in 2009 and at follow-up (≤12 years later) we

Objective: To explore associations between high midnight salivary cortisol (MSC) secretion and high blood pressure (BP) in type 1 diabetes (T1D). Methods: Cross-sectional study of 196 adult patients with T1D (54% men). Associations between high MSC (≥9.3 nmol/L) and high systolic BP (>130 mmHg), and high diastolic BP (>80 mmHg) were explored for all patients, users and non-users of antihypertensiv

Background: The usage of probiotics has expanded beyond the areas of gut and immune health improvement. Several studies have shown the positive impact associated between probiotics and stress, cognition, and mood; a relationship referred to as the gut–brain axis. Method: The aim of this exploratory study was to evaluate the effect of the probiotic strain Lactiplantibacillus plantarum HEAL9 (LPHEAL

Klebsiella pneumoniae and Pseudomonas aeruginosa are two leading causes of burn and wound infections, pneumonia, urinary tract infections, and more severe invasive diseases, which are often multidrug resistant (MDR) or extensively drug resistant. Due to this, it is critical to discover alternative antimicrobials, such as bacteriophage lysins, against these pathogens. Unfortunately, most lysins tha

Sprays are commonly found in, among other, combustion, agriculture and food processing. For each of these applications, the understanding of spray liquid dynamics is crucial for optimization of efficiency, accuracy, and robustness of the spray­-system in use. Sprays are also found as a collection of respiratory droplets ejected when people are speaking, yelling, coughing etc. that is one of the ma

Phenotypic drug discovery (PDD) enables the target-agnostic generation of therapeutic drugs with novel mechanisms of action. However, realizing its full potential for biologics discovery requires new technologies to produce antibodies to all, a priori unknown, disease-associated biomolecules. We present a methodology that helps achieve this by integrating computational modeling, differential antib

Background. The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries. Methods. The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General p

A well-conducted systematic review requires a scrupulous assessment of the design of included studies. This may unveil major issues in how studies were planned, conducted and reported. This section presents a few examples. 1) A Cochrane review on pain and sedation management in the newborn identified a study described as a randomized trial, which later, following communication with authors and the