The respiratory pathogen Moraxella catarrhalis is a human-specific commensal that frequently causes acute otitis media in children and stimulates acute exacerbations in chronic obstructive pulmonary disease patients. The exact molecular mechanisms defining host-pathogen interactions promoting pathogenesis are not clearly understood. Limited knowledge hampers vaccine and immunotherapeutic developme

Development of multiple colorectal cancers (CRCs), synchronously or metachronously, is associated with hereditary predisposition for cancer and accurate risk estimates of multiple tumour development are relevant to recommend rational surveillance programs. A cross-sectional study design was used to estimate the risks of synchronous CRC (SCRC) and metachronous CRC (MCRC) based on data from the Nati

An historical essay for the exhibition Lust & Vice in the Visual Arts, Nationalmuseum, Stockholm 2011.

BACKGROUND: Falls are common among older people with intellectual disability (ID) and are also a major contributor to injuries in this population. Yet, fall characteristics have only been sparsely studied, and the results are inconsistent. The aim of the present study was to investigate type of falls, places where they occurred and activities that caused them, as well as health outcomes and health

Personporträtt av tolv individer - studenter, anställda eller anhöriga till anställda - med koppling till Lunds universitet från 1600-tal till 1900-tal.

Patient-derived xenografts (PDX) and the Avatar, a single PDX mirroring an individual patient, are emerging tools in preclinical cancer research. However, the consequences of intratumor heterogeneity for PDX modeling of biomarkers, target identification, and treatment decisions remain underexplored. In this study, we undertook serial passaging and comprehensive molecular analysis of neuroblastoma

The detection of intermediate-mass black holes (IMBHs) in Galactic globular clusters (GCs) has so far been controversial. In order to characterize the effectiveness of integrated-light spectroscopy through integral field units, we analyse realistic mock data generated from state-of-the-art Monte Carlo simulations of GCs with a central IMBH, considering different setups and conditions varying IMBH

We discuss a new scenario for the formation of intermediate mass black holes (IMBHs) in dense star clusters. In this scenario, IMBHs are formed as a result of dynamical interactions of hard binaries containing a stellar-mass black hole (BH), with other stars and binaries. We discuss the necessary conditions to initiate the process of intermediate mass BH formation and the influence of an IMBH on t

Gaia DR1 is based on the first 14 months of Gaia's observations. This is not long enough to reliably disentangle the parallax effect from proper motion. For most sources, therefore, only positions and magnitudes are given. Parallaxes and proper motions were nevertheless obtained for about two million of the brighter stars through the Tycho-Gaia astrometric solution (TGAS), combining the Gaia obser

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of

Locally Stationary Processes (LSPs) in Silverman’s sense, defined by the modulation in time of a stationary covariance function, are valuable in stochastic modelling of time-varying signals. However, for practical applications, methods to conduct reliable parameter inference from measured data are required. In this paper, we address the lack of suitable methods for estimating the parameters of the

Analys av den kulturpolitiska debatt som föregick inrättandet av Bror Hjorths hus i Uppsala 1978. Baseras på mediarapportering, inlägg och uppföljande intervjuer.

A baseflow separation methodology combining the outcomes of the flow–duration curve and the digital filtering algorithms to cope with the restrictions of traditional procedures has been assessed. Using this methodology as well as the monitored and simulated hydro-climatological data, the baseflow annual variations due to climate change and human-induced activities were determined. The outcomes sho

Behandlar den klassiska och fornnordiska mytologin i konsten, vilka användes i utformandet av Röda salongen på Rosendal för att skapa en apoteos av Karl XIV Johan.

Most large tidewater glaciers in Svalbard are known to have surged at least once in the last few hundred years. However, very little information exists on the frequency, timing or magnitude of surges prior to the Little Ice Age (LIA) maximum in ∼1900. We investigate the sediment-landform assemblages produced by multiple advances of the Nathorstbreen glacier system (NGS) in order to reconstruct its

The Swedish Cambrian ‘Orsten’-type fossil sites have yielded diverse secondarily phosphatized three-dimensionally preserved microfossils, mainly of arthropod affinities. Similar material has also been recorded from Canada, the UK, Poland, Siberia, China and Australia. Only one other non-arthropod group, the Cycloneuralia, is commonly reported from any of these sites, leading to the general assumpt

A cultivation strategy for the production of two truncated thermostable recombinant xylanases (Xyn1ΔN and Xyn1ΔNC) was developed. Fed-batch cultivations of Escherichia coli strain BL21(DE3) with a controlled exponential glucose feed led to high specific production of the recombinant proteins. Addition of complex nutrients (e.g. Tryptone Soya Broth (TSB)) to the media were shown to increase both th

An integrated flow-injection processing (FIP) system for the quantification of plasmids during cultivation is described. The system performs on-line sampling, cell lysis, and quantification of plasmids in an integrated manner during cultivation of E. coli. The system was operated by using a miniaturized expanded-bed column which can be used for handling samples containing cells and cell debris wit

We study spin transport in the one- and two-electron regimes of parallel-coupled double quantum dots (DQDs). The DQDs are formed in InAs nanowires by a combination of crystal-phase engineering and electrostatic gating, with an interdot tunnel coupling (t) tunable by one order of magnitude. Large single-particle energy separations (up to 10 meV) and |g∗| factors (∼10) enable detailed studies of the