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The genetic landscape of paediatric de novo acute myeloid leukaemia as defined by single nucleotide polymorphism array and exon sequencing of 100 candidate genes

Cytogenetic analyses of a consecutive series of 67 paediatric (median age 8 years; range 0-17) de novo acute myeloid leukaemia (AML) patients revealed aberrations in 55 (82%) cases. The most common subgroups were KMT2A rearrangement (29%), normal karyotype (15%), RUNX1-RUNX1T1 (10%), deletions of 5q, 7q and/or 17p (9%), myeloid leukaemia associated with Down syndrome (7%), PML-RARA (7%) and CBFB-M

Vitamin D, PTH, and calcium in relation to survival following prostate cancer

PURPOSE: Epidemiological studies suggest that low levels of vitamin D constitute a risk factor for prostate cancer. However, the results are conflicting, perhaps because prostate cancer is a very heterogeneous disease. More recent studies have focused on cancer progression and mortality. Vitamin D is closely related to both calcium metabolism and parathyroid hormone (PTH) levels, and all three fac

Modeling of mass and charge transport in a solid oxide fuel cell anode structure by a 3D lattice Boltzmann approach

A 3D model at microscale by the lattice Boltzmann method (LBM) is proposed for part of an anode of a solid oxide fuel cell (SOFC) to analyze the interaction between the transport and reaction processes and structural parameters. The equations of charge, momentum, heat and mass transport are simulated in the model. The modeling geometry is created with randomly placed spheres to resemble the part o

"I'm an ordinary faggot" – Scripts of male homosexuality in urban and rural Sweden in the 1940s

The paper explores the flux of male homosexual identity between urban subcultures and small rural settings in Sweden. Eve Kosofsky Sedgwick has claimed that we cannot interpret Foucault’s History of Sexuality as if one understanding of sexuality was substituted by another, but that many forms of sexuality coexist in any given time. Inspired by her analysis, this paper claims that a shift between t

Contact angles of ultrafiltration membranes and their possible correlation to membrane performance

The captive bubble method was used to describe the wetting characteristics of a number of commercial ultrafiltration (UF) membranes. The membranes belonged to one of two homologous (same material, different cut-off) series made by the same manufacturer. One series was made of polysulphone and the other one of cellulose triacetate. The porosimetric characteristics of the membranes have also been me

Adsorption of protein fractions from wheat onto methylated silica surfaces

The kinetics of the sequential adsorption of gliadins and water-soluble fraction (WSF) from the wheat variety Kosack onto hydrophobic silica (methylated silica) surfaces were studied by in situ ellipsometry. The measurements were made in water and in 0.01M acetate buffer, pH 4.0 and 5.0, with and without 0.1M NaCl. The concentration of gliadins and WSF was 1.7 µg/ml. The adsorption of gliadins in

Structural Stability Effects on Adsorption and Dodecyltrimethylammonium Bromide-Mediated Elutability of Bacteriophage T4 Lysozyme at Silica Surfaces

The effect of structural stability on the adsorption and dodecyltrimethylammonium bromide (DTAB)-mediated elutability of bacteriophage T4 lysozyme was monitored at hydrophilic and hydrophobic silica surfaces with in situ ellipsometry. Mutant lysozymes were produced by substitution of the isoleucine at amino acid position three, yielding a set of proteins with values of ΔGunfolding ranging from 1.2

Signe & Iris - svenska socialingenjörer

I början av 1900-talet kom socialingenjören/socialsekreteraren från Amerika och England till Sverige i skepnad av personalkonsulent, förmedlad av yrkesinspektrisen Kerstin Hesselgren. Flera kvinnliga personalkonsulenter tog steget över till yrkesinspektionen. Ett par av dem – Signe Holst och Iris Christiansson – reste till USA för att studera företagens personalarbete. Historien om »Signe & Ir

Assessing movement quality in persons with severe mental illness - Reliability and validity of the Body Awareness Scale Movement Quality and Experience

Motor disturbances and disturbed self-recognition are common features that affect mobility in persons with schizophrenia spectrum disorder and bipolar disorder. Physiotherapists in Scandinavia assess and treat movement difficulties in persons with severe mental illness. The Body Awareness Scale Movement Quality and Experience (BAS MQ-E) is a new and shortened version of the commonly used Body Awar

Risk factors for unnatural death : Fatal accidental intoxication, undetermined intent and suicide: Register follow-up in a criminal justice population with substance use problems

BACKGROUND: Risk factors for suicide and fatal accidental intoxication are extensively studied, while risk factors for intoxications/injuries of undetermined intent are less well known. The latter have shown an overlap with suicides, but also with fatal accidental intoxications. The objective was to analyze potential differences and similarities in the patterns of risk factors for accidental intox

Incretin hormone receptors are required for normal beta cell development and function in female mice

The incretin hormones, glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), potentiate insulin secretion and are responsible for the majority of insulin secretion that occurs after a meal. They may also, however, have a fundamental role in pancreatic beta cell development and function, independently of their role in potentiating insulin secretion after a meal. Th