Hard candy is hygroscopic, implying that hard candy readily absorbs moisture from the environment, resulting in adverse changes in the texture and appearance of the candy. This thesis investigates the impact of different sugar compositions on the moisture absorption of hard candy when exposed to a humid environment. Five different hard candy formulations were exposed to an 8-day storage experiment

TAR DNA-binding protein-43 (TDP-43) accumulation is the primary pathology underlying several neurodegenerative diseases. Charting the progression and heterogeneity of TDP-43 accumulation is necessary to better characterize TDP-43 proteinopathies, but current TDP-43 staging systems are heuristic and assume each syndrome is homogeneous. Here, we use data-driven disease progression modelling to deriv

III-V-based Indium gallium arsenide is a promising channel material for high-frequency applications due to its superior electron mobility property. In this thesis, InGaAs/InP heterostructure radio frequency MOSFETs are designed, fabricated, and characterized. Various spacer technologies, from high dielectric spacers to air spacers, are implemented to reduce parasitic capacitances, and fT/fmax are

Inflammasomes are large multiprotein complexes that assemble mainly in innate immune cells after detection of microbial or sterile insults. Activation of inflammasomes is a key proinflammatory event during infection, and many pathogens have evolved specific evasion mechanisms to evade or inhibit inflammasome activation. One such pathogen is the common bacterium group A Streptococcus (GAS), which c

OBJECTIVES: We aim to clarify the pathogenic role of intermediate size repeat expansions of SCA2, SCA3, SCA6, and SCA17 as risk factors for idiopathic Parkinson disease (PD).METHODS: We invited researchers from the Genetic Epidemiology of Parkinson's Disease Consortium to participate in the study. There were 12,346 cases and 8,164 controls genotyped, for a total of 4 repeats within the SCA2, SCA3,

Surrogacy is prohibited in many European states. However, such a ban is not global. This can create problems when individuals from states where surrogacy is prohibited travel to other states where it is allowed and become legally recognised parents of children born through surrogacy in the latter states. The implications of cross-border surrogacy come into reality when the intended parents return

Background and objectives: Acute myeloid leukemia (AML) is the most common type of leukemia in adults with relatively high recurrence. Interferon alpha (IFNa) is a type I interferon and it has been shown to have a therapeutic effect on myeloid malignancies in clinical research especially to prevent potentially risky AML recurrence after chemotherapy. Due to the molecular heterogeneity of the disea

This paper examines the extent of income inequality that is attributed inherited circumstances such as social and family background, denoted as Inequality of Opportunity or IOp, for natives and second-generation immigrants in Sweden. The measurement of Inequality of Opportunity captures the between-type inequality, when individuals are grouped into types based on these predetermined circumstances,

The role of food-producing sectors such as agriculture and aquaculture in the development process is debated and while some consider industrial production to be the answer, others suggest that small-scale production can also make contributions to poverty reduction and food security. This thesis aims to shed light on these relationships by performing quantitative analyses of the small-scale freshwa

This thesis investigates the relationship between economic growth and income inequality in the European Union from 1991 to 2019, alongside examining the impact of EU membership on income inequality in Eastern European nations. The theoretical basis of the research is the Kuznets theory, and the study will utilise data from the World Bank’s World Development Indicators and employ a graphical method

The rapidly evolving domain of network systems poses complex challenges, especially when considering scalability and transient behaviors. This thesis aims to address these challenges by offering insights into the transient analysis and control design tailored for large-scale network systems. The thesis consists of three papers, each of which contributes to the overarching goal of this work.The fir

The paper examines the impact of the mining sector's closure on population decline patterns in the Principality of Asturias, Spain. It utilizes two distinct databases of own construction that provide disaggregated data on the region's 78 councils. The first database encompasses demographic information spanning from 1900 to the present day, while the second database contains socioeconomic d

This thesis aims at investigating the effect of corruption on economic growth in Europe, as well as Western and Eastern Europe separately. In particular, I ask the following two research questions: Does corruption in Europe have a negative effect on economic growth at an aggregate level? Does this effect change when dividing my data set into two sub-samples, each consisting of countries with simil

In the present study, corrugated-core and X-core sandwich panels with multi-layer and multi-row lightening holes are designed from the perspective of extending the thermal short-circuit path. The thermal insulation performance and load-bearing capacity of the integrated thermal protection structure are investigated and enhanced by sequential thermal–mechanical coupling method. For the corrugated-c

SARS-CoV-2 Antagonism of IFN Signalling Pathways. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). The rapid spread of the virus raised concerns for the major gap in knowledge of infectious viral diseases. Understanding how the virus modulates host innate immune responses is crucial for development of therapeutic strategie

Syfte Undersöka konsumenters köp- och returbeteenden vad gäller kläder vid införandet av striktare returpolicys. Teoretiska perspektiv Returbeteende, Categories of online returning behavior, Returpolicy, CSR, Carroll’s Pyramid of Corporate Social Responsibility, Tidigare forskning, Grandiositet och nollsummespel Metod Uppsatsen utgår från en kvantitativ undersökningsmetod och deduktiv ansats. DePurpose To investigate consumer purchasing and return behaviors regarding clothing when introducing stricter return policies. Theoretical perspective Returning behavior, Categories of online returning behavior, Return policies, CSR, Carroll’s Pyramid of Corporate Social Responsibility, Grandiosity and Zero-sum games Methodology The essay is based on a quantitative research method and deductive a