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Photoactivation of Drosophila melanogaster cryptochrome through sequential conformational transitions

Cryptochromes are blue-light photoreceptor proteins, which provide input to circadian clocks. The cryptochrome from Drosophila melanogaster (DmCry) modulates the degradation of Timeless and itself. It is unclear how light absorption by the chromophore and the subsequent redox reactions trigger these events. Here, we use nano- to millisecond time-resolved x-ray solution scattering to reveal the lig

Symptom-specific effects of cognitive-behavioral therapy, sertraline, and their combination in a large randomized controlled trial of pediatric anxiety disorders

Background: Pediatric anxiety disorders are highly prevalent and associated with significant functional disabilities and lifelong morbidity. Cognitive-behavioral therapy (CBT), sertraline, and their combination are effective treatments, but little is known about how these treatments exert their effects.Methods: Using network intervention analysis (NIA), we analyzed data from the largest randomized

'A good place to live' : Rethinking residents' place satisfaction and the role of co-creation

Developing a place into ‘a good place to live’ for people of all ages is a prioritized issue in many municipalities in Sweden, as well as around the world. But what do we really mean by ‘a good place to live’? How do the residents themselves comprehend and perceive ‘a good place to live’? And how do municipalities view their place and what they offer to their residents? This thesis explores how ‘a

Landscapes of Dispossession : The Production of Space in Northern Tanintharyi, Myanmar

Since 2007, rural areas, particularly across the global south, have been ravaged by what has been dubbed a “global resource rush”. On the heels of this rush, a new wave of dispossession studies across the fields of agrarian political economy, human geography and political ecology is emerging. A decade into this wave, a series of conceptual challenges in the literature are identifiable, namely 1) t

Linkages between N turnover and plant community structure in a tundra landscape

The spatial distribution of organic soil nitrogen (N) in alpine tundra was studied along a natural environmental gradient, covering five plant communities, at the Latnjajaure Field Station, northern Swedish Lapland. The five communities (mesic meadow, meadow snowbed, dry heath, mesic heath, and heath snowbed) are the dominant types in this region and are differentiated by soil pH. Net N mineraliza