Effect of antisecretory factor, given as a food supplement to adult patients with severe traumatic brain injury (SASAT) : protocol for an exploratory randomized double blind placebo-controlled trial
BACKGROUND: Traumatic brain injury (TBI) constitutes a global epidemic. Overall outcome is poor, with mortality ranging from 10 to 70% and significant long-term morbidity. Several experimental reports have claimed effect on traumatic edema, but no clinical trials have shown effect on edema or outcome. Antisecretory factor, an endogenous protein, is commercially available as Salovum®, which is clas