BACKGROUND: Individual randomized controlled trials (RCTs) of periprocedural anticoagulation with bivalirudin versus heparin during percutaneous coronary intervention (PCI) have reported conflicting results. Study-level meta-analyses lack granularity to adjust for confounders, explore heterogeneity, or identify subgroups that may particularly benefit or be harmed. OBJECTIVE: To overcome these limi

Bispecific antibodies come in many different formats, including the particularly interesting two-in-one antibodies, where one conventional IgG binds two different antigens. The IgG format allows these antibodies to mediate Fc-related functionality, and their wild-type structure ensures low immunogenicity and enables standard methods to be used for development. It is however difficult, time-consumi

PURPOSE: The purpose was to examine long-term consequences of exposure to electrical current passing through the body. We investigated (1) whether electricians after having experienced an electrical accident report more cognitive problems and lower mental wellbeing and (2) have objectively verifiable reduced cognitive function; and (3) which circumstances at the time of the accident affect long-te

The present research aims at understanding the value of travel guidebooks as an object of consumption in the context of the digital age. It does so by applying a consumer value perspective to an object that has traditionally been studied as an information channel or as a cultural text and not as an object of consumption. Holbrook’s consumer value framework was adopted to identify the value dimensi

The Nordic doctorate has its roots in the Germanic Bildung-tradition, with a decentralised and discipline-oriented curriculum, local and individualised leadership and autonomous supervisors. Currently, the Nordic doctorate has arrived at a crossroads where it is pulled in two different directions. The first characterised by formalisation and centralised Graduate Schools with study directors, middl

Starting from next year the technical feasibility of a direct seeding scheme at 30 and 13 nm will be studied at the Free-electron LASer in Hamburg (FLASH). During a major shutdown the SASE-FEL facility will be upgraded and it is planned to install in addition a high-harmonic generation (HHG) seed laser, a new chain of 10 m variable gap un-dulators and a dedicated commissioning beamline for photon

We demonstrate for the first time that seeded harmonic generation on electron storage rings can produce coherent optical pulses in the vacuum ultraviolet spectral range. The experiment is performed at Elettra, where coherent pulses are generated at 132nm, with a duration of about 100fs. The light source has a repetition rate of 1kHz and adjustable polarization; it is very bright, with a peak power

Taking advantage of the storage ring free electron laser beamline at Elettra, we have implemented an experimental setup for the generation of sub-picosecond (ps) coherent optical pulses in the VUV range. The setup is based on the frequency up-conversion of a high-power external signal (provided by a Ti:Sapphire laser) and makes use of a relativistic electron bunch as resonating medium. The produce

The Free-electron-laser at Hamburg (FLASH) operates in the Self-Amplified Spontaneous Emission (SASE) mode, delivering to users photons in the XUV wavelength range. The FEL seeding schemes promise to improve the properties of the generated radiation in terms of stability in intensity and time. Such an experiment using higher harmonics of an optical laser as a seed is currently under construction a

This study investigates the incremental validity of changes in ten stress-related acute dynamic risk factors, collected through automated telephony over 30 consecutive days following parole, for predicting time to recidivism during the following year. Before release, the participants completed self-report assessment of some stable risk factors–impulsiveness and history of problematic substance use

There is growing awareness and international commitment to improving sexual and reproductive health for persons with intellectual disabilities. Despite this, people with intellectual disabilities continue to face stigma and have limited access to sexual health education and information. This qualitative phenomenological study uses data from 10 interviews to describe what it means to teach sexual a

The 19th century in Sweden, like in many other European countries, saw a largedecline in the quantity of Neo-Latin literary production. However, a range of skillful Latin poets may be named from this period: Johan Lundblad, Johan Tranér, Emil Söderström, Johan Bergman and others, engaged as well in translating from Swedish into Latin as in composing poems of their own. It was also in the 19th cent

Recent research suggests an important role of the meniscus in the development of knee osteoarthritis. We, therefore, aimed to analyze the proteome of the normal human meniscus body, and specifically to gain new knowledge on global protein expression in the different radial zones. Medial menisci were retrieved from the right knees of 10 human cadaveric donors, from which we cut a 2 mm radial slice

Clonal heterogeneity and evolution has major implications for disease progression and relapse in acute myeloid leukemia (AML). To model clonal dynamics in vivo, we serially transplanted 23 AML cases to immunodeficient mice and followed clonal composition for up to 15 months by whole-exome sequencing of 84 xenografts across two generations. We demonstrate vast changes in clonality that both progres

BACKGROUND: The diagnostic weight of the first-rank symptoms was deemphasized in DSM-5 and a similar change is expected in ICD-11. This change was motivated by a lack of solid, empirical evidence of the diagnostic significance of first-rank symptoms for schizophrenia. Yet, it seems that Schneider's original concept of first-rank symptoms was overly simplified when it was introduced in DSM-III. Spe