Filtyp
Epilepsy is a severe chronic neurological disorder characterized by recurrent spontaneous seizures. Excitatory/inhibitory (E/I) imbalance, neuronal loss, brain inflammation, and altered adult neurogenesis are some of the characteristic hallmarks of epilepsy. Seizures increase the production of new hippocampal neurons but their function in the epileptic brain is still not fully understood. Elucidat
We present a theoretical study of two coupled diffusion processes through a membrane which is able to respond to the presence of the diffusing substances with a phase change. The case we consider is when the direct driving force for one of the processes vanishes, i.e. when the chemical potential of one of the components, or some other intensive variable, is kept equal in the two reservoirs surroun
Abstract in UndeterminedThis paper analyzes and evaluates the 2007 majority opinion of the German National Ethics Council which seeks to establish new information (as to the inferior quality of legally procurable human embryonic stem cells) as a sufficient reason for a relaxation of the 2002 Stem Cell Law. A micro-level analysis of the opinion’s central section is conducted and evaluated vis à vis
The polymeric immunoglobulin receptor (pIgR) is a key component of the mucosal immune system that mediates epithelial transcytosis of immunoglobulins. High pIgR expression has been reported to correlate with a less aggressive tumour phenotype and an improved prognosis in several human cancer types. Here, we examined the expression and prognostic significance of pIgR in pancreatic and periampullary
This paper describes the design of a robust PID controller for propofol infusion in children and presents the results of clinical evaluation of this closed-loop system during endoscopic investigations in children age 6y-17y. The controller design is based on a set of models that describes the inter- patient variability in the response to propofol infusion in the study population. The PID controlle
This article investigates the relation between conceptions of status and processes of militarization of peasants in the medieval and early-modern society. In an initial overview we see how many revolts in western Europe in late middle ages were connected to an increased military participation of peasant groups. After 1500 similar processes can be found in the east european frontier regions. Econom
BACKGROUND AND PURPOSE: We report trends of stroke incidence and survival up to year 2001/2002 in Lund-Orup, Sweden, and projections of future stroke incidence in Sweden. METHODS: Lund Stroke Register, a prospective population-based study, included all first-ever stroke patients, between March 1, 2001 and February 28, 2002, in the Lund-Orup health care district. Institution-based studies for 1983
The charge state of proteins in solution is a key biophysical parameter that modulates both long and short range macromolecular interactions. However, unlike in the case of many small molecules, the effective charges of complex biomolecules in solution cannot in general be predicted reliably from their chemical structures alone. Here we present an approach for quantifying the effective charges of
The cysteine proteinase inhibitor cystatin C inhibited RANKL-stimulated osteoclast formation in mouse bone marrow macrophage cultures, an effect associated with decreased mRNA expression of Acp5, Calcr, Ctsk, Mmp9, Itgb3, and Atp6i, without effect on proliferation or apoptosis. The effects were concentration dependent with half-maximal inhibition at 0.3 M. Cystatin C also inhibited osteoclast form
Although Cloud Sourcing has been around for some time it could be questioned what actually is known about it. This paper presents a literature review on the specific question if Cloud Sourcing could be seen as the next generation of outsourcing. The reason for doing this is that from an initial sourcing study we found that the sourcing decisions seems to go in the direction of outsourcing as a ser
Four unconjugated diimine palladium complexes have been synthesized, and spectroscopically and structurally characterized. All four palladium complexes were used as catalysts in the Heck coupling reaction between iodobenzene and methyl acrylate or butyl acrylate with very good conversion to either methyl (2E)-3-phenylacrylate or butyl (2E)-3-phenylacrylate.
Can a climate-triggered export of old contaminants from the soil alter the lead (Pb) contaminant burden of subarctic lakes? To address this question, we reconstructed the pollution history of three high latitude lakes situated in a region where a recent climatic shift has occurred. Dated sediment records were used as archives of past Pb inputs to the lakes, where the difference in the (206)Pb/(207
Context. To use the data in the future Gaia catalogue it is important to have accurate estimates of the statistical uncertainties and correlations of the errors in the astrometric data given in the catalogue. Aims. In a previous paper we derived a mathematical model for computing the covariances of the astrometric data based on series expansions and a simplified attitude description. The aim of th
