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PARP14/BAL2 is a large multidomain enzyme involved in signaling pathways with relevance to cancer, inflammation, and infection. Inhibition of its mono-ADP-ribosylating PARP homology domain and its three ADP-ribosyl binding macro domains has been regarded as a potential means of therapeutic intervention. Macrodomains-2 and -3 are known to stably bind to ADP-ribosylated target proteins, but the func
PARP14 is a mono-ADP-ribosyl transferase involved in the control of immunity, transcription, and DNA replication stress management. However, little is known about the ADP-ribosylation activity of PARP14, including its substrate specificity or how PARP14-dependent ADP-ribosylation is reversed. We show that PARP14 is a dual-function enzyme with both ADP-ribosyl transferase and hydrolase activity act
Advancement of the maxilla may increase the distance between the soft palate and the posterior pharyngeal wall in patients with cleft lip and palate, implying a risk of velopharyngeal dysfunction. The aim was to evaluate long-term speech outcome in a consecutive series of patients treated with distraction osteogenesis (DO). Fourteen out of the 16 patients agreed to participate. A long-term speech
The research aim of this article is to generate novel insights into how public sector organizations (PSOs) strategically communicate with the public about critical issues on social media. To this end, the study explores the public's experiences of the Swedish Police's sense of safety communication on Instagram in the third largest city in Sweden, where the lack of a sense of public safety is a mai
This paper presents a stabilized scheme that solves the wave propagation problem in a general bianisotropic, stratified medium. The method utilizes the concept of propagators, i.e., the wave propagation operators that map the total tangential electric and magnetic fields from one plane in the slab to another. The scheme transforms the propagator approach into a scattering matrix form, where a spec
The Temporary Protection Directive does not contribute to an effective integration process. Measures to facilitate refugee integration need to be put in place even if return is the preferred durable solution.
Picture books are often part of children's socialisation processes, contributing to the children forming images of the world, including ideas about (categories of) people, such as nurses. The study aims to explore how nurses/nursing are portrayed in children's picture books in a Swedish context. Through a systematic search, 44 books were included for analysis using thematic analysis and a theoreti
In chemistry education, student learning difficulties involve connecting theory and phenomena to make sense of chemistry, as well as utilising and understanding the language of chemistry. In this thesis, I examine the relationships among student language use, previous achievement level, and sensemaking in chemistry, as well as how experienced teachers help students make sense of chemistry as part
Increasing the amount of renewable generation in distribution networks is a fundamental part of the energy transition. Multiple methods exist to increase the hosting capacity in a grid, to allow larger injections of generation and more efficiently utilize existing infrastructure before operational limits are breached. In this thesis, the method studied for this is network reconfiguration. Many dis
This chapter includes an analysis how three major Swedish cities manage their strategy and control during transformative and complex capacity challenges. In particular, it extends our knowledge and contributes to NPM research concerning why and how local governments chose to adopt certain strategies and control actions to manage external pressure from a growing population. This is accomplished by
The Arctic has warmed more than twice the rate of the entire globe. To quantify possible climate change effects, we calculate wind energy potentials from a multi-model ensemble of Arctic-CORDEX. For this, we analyze future changes of wind power density (WPD) using an eleven-member multi-model ensemble. Impacts are estimated for two periods (2020–2049 and 2070–2099) of the 21st century under a high
Under mitt fältarbete kring graffiti var ”ska vi inte gå och ta en öl?” en återkommandeuppmaning bland deltagarna, även formulerad som ”gå ut och röka”, ”ta en promenad”, osv. Även om dessa förslag i sig knappast är unika för graffiti, visade sig deras betydelser och konsekvenser vara just det. I detta kapitel ska jag analysera hur dessa sociala uppmaningar användes som subkulturella eufemismer fö
Fluorescent probes based on photoinduced electron transfer (PET) quenching of long lifetime triangulenium fluorophores have found multiple applications. For such probes a successful design relies on the right balance between the rate of PET quenching and fluorescence. In a series of ADOTA (A) and DAOTA (D) triangulenium fluorophores appended with aniline-like quencher moieties, we have investigate
En teknik för att förhindra yterosion och samla ytavrinning är bygga jordvallar (1–1,5 m höga) parallellt medhöjdkurvorna. Denna teknik används över stora områden i Tunisien. I denna studie undersöks hur dessa jord-vallar påverkar ytjordens rumsliga variabilitet av markvattenhalt (θ) och salinitet, dels uttryckt som jordenstotala elektriska konduktivitet (σa) och dels som porvattnets elektriska koOne technique for collecting rainwater and prevent soil erosion applied on large areas in Tunisia involves theuse of soil ridges (1–1.5 m high). These contour ridges are constructed parallel to topographical isolines. Theeffects of the contour ridges on the soil water content (θ) distribution, bulk soil salinity σa, and soil water salin-ity (σw) were investigated in the catchment of El-Gouazine in
Background: Healing failure after rotator cuff repair is a challenging problem. Acute, trauma-related tears are considered a separate entity and are often treated surgically. The aim of this study was to identify factors associated with healing failure in previously asymptomatic patients with trauma-related rotator cuff tears treated with early arthroscopic repair. Methods: This study included 62
This paper addresses the hybrid quantized signal detection problem in a distributed radar system, where widely separated antennas transmit low-bit quantized data with varying quantization levels depending on the different bandwidth constraint for each channel to a fusion center. To enable a high detection performance with such hybrid quantized data, we formulate the generalized likelihood ratio, R
