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Vertebral compression fractures (VCFs) are the most prevalent fractures in osteoporotic patients. The classical conservative management of these fractures is through rest, pain medication, bracing and muscle relaxants. The aim of this paper is to review prospective controlled studies comparing the efficacy and safety of minimally invasive techniques for vertebral augmentation, vertebroplasty (VP)
Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and exp
Attosecond pulses are used to study electron dynamics in atoms and molecules. In this thesis, schemes to control the generation of attosecond pulses and pulse-shaping techniques to compress the pulses are presented. Generation of attosecond pulses requires high intensity, which is reached by focusing a pulsed femtosecond laser. The emitted pulses come isolated or in an attosecond pulse train (APT
The move towards fire performance-based design in building and transport regulations has led to an increased use of fire models. This increased use of these models and the evolution of different regulations have put higher demands on the predictive capability of fire models. The purpose of this paper is to give an overview of different activities relating to the validation and verification of comp
Generalized frequency division multiplexing (GFDM) is a new concept that can be seen as a generalization of traditional OFDM. The scheme is based on the filtered multi-carrier approach and can offer an increased flexibility, which will play a significant role in future cellular applications. In this paper we present the benefits of the pulse shaped carriers in GFDM. We show that based on the FFT/I
Tasquinimod, an orally active quinoline-3-carboxamide, binds with high affinity to HDAC4 and S100A9 in cancer and infiltrating host cells within compromised tumor microenvironment inhibiting adaptive survival pathways needed for an angiogenic response. Clinical trials document that as low as 0.5-1mg tasquinimod/day is therapeutic against castrate resistant metastatic prostate cancer. Tasquinimod i
A method to compute distributed dipole-quadrupole polarizabilities is suggested. The method is based on numerical differentiation of distributed quadrupole moments, using finite field perturbation calculations. It is tested using two different multicenter multipole expansions, and compared with results using polarizabilities obtained via the uncoupled Hartree-Fock approximation. The accuracy of th
BackgroundRescue therapy with infliximab (IFX) has been proven effective in a steroid-refractory attack of ulcerative colitis (UC). The long-term efficacy is not well described. AimTo present a retrospective study of IFX as rescue therapy in UC. Primary end points were colectomy-free survival at 3 and 12months. MethodsIn this multicentre study, 211 adult patients hospitalised between 1999 and 2010
Abstract in UndeterminedOver the last decade a great deal of research attention has been paid to the Internet as a potential vehicle for civic and/or political engagement among young people. Many of these analyses have been looking (or perhaps hoping) for a simple cause-and-effect relationship. Young people seem uninterested in traditional forms of politics, but they are very interested in Interne
The recent literature on the duration of trade has predominantly analyzed the determinants of trade flow durations using Cox proportional hazards models. The purpose of this paper is to show why it is inappropriate to analyze the duration of trade with continuous-time models such as the Cox model, and to propose alternative discrete-time models which are more suitable for estimation. Briefly, the
Objective: To evaluate if remission induced by low-dose prednisolone during the first 2 years of rheumatoid arthritis (RA) in the BARFOT glucocorticoid (GC) study had a sustained effect on radiological damage for a total of 4 years. Methods: A total of 150 of 211 eligible patients with RA who had been randomised to the 7.5 mg prednisolone group ( P) or no prednisolone group (NoP) in addition to th
This study focuses on the statistical description and analysis of road surface irregularities that are essential for heavy-vehicle fatigue assessment. Three new road profile models are proposed: a homogenous Laplace moving average process, a non-homogenous Laplace process and a hybrid model that combines Gaussian and Laplace modelling. These are compared with the classical homogenous Gaussian proc
