The application of a formulation on the skin represents an effective way to deliver bio-active molecules for therapeutical purposes. Moreover, the outermost skin layer, the stratum corneum, can be overcome by employing chemical permeation enhancers and edge activators as components. Several lipids can be considered as permeation enhancers, such as the ubiquitous monoolein, one of the most used bui

The skate Leucoraja erinacea has an elaborately shaped pupil, whose characteristics and functions have received little attention. The goal of our study was to investigate the pupil response in relation to natural ambient light intensities. First, we took a recently developed sensory-ecological approach, which gave us a tool for creating a controlled light environment for behavioural work: During a

There are many things to consider when implementing an adaptive controller. The paper contains a discussion of some of these issues. When an adaptive controller is going to to work in an industrial environment it is of outmost importance that the designer has thought of all situations and combination of conditions that may occure. Special attention is given to the interaction between the controlle

BACKGROUND: Per-and polyfluoroalkyl substances (PFAS) are widespread and persistent pollutants that have been associated with elevated cholesterol levels. However, data on incident cardiovascular disease (CVD) is lacking. OBJECTIVES: We investigated the association of exposure to PFAS with risk of myocardial infarction and stroke and, subsidiary, with baseline blood lipids. METHODS: This populatio

OBJECTIVE: Previous literature has suggested that identifying putative differences in health care seeking patterns before death by suicide depending on age and gender may facilitate more targeted suicide preventive approaches. The aim of this study is to map health care utilisation among individuals in the two years prior to suicide in Sweden in 2015 and to examine possible age and gender differen

This article revisits the origins of Khomeini's concept of the guardianship of the jurisconsult (wilāyat al-faqīh) and argues that his own formulation of this concept needs to be embedded in debates around the clerical mandate in the state among clerical activists in Iraq he encountered during his exile. Focus will be on the so-called Shīrāzī network around the brothers Muhammad (1928-2001), Hasan

Circulatory failure is considered one of the entities of the post cardiac arrest syndrome contributing to poor outcome. It is reported at 15-70% of all patients successfully resuscitated from out-of-hospital cardiac arrest (OHCA). The pathophysiologic mechanism is attributed to limitation of cell metabolism due to inadequate supply of oxygen, caused by pump or conduction failure within the cardiov

The spinal cord is engaged in all forms of motor performance but its functions are far from understood. Because network connectivity defines function, we explored the connectivity of muscular, tendon, and tactile sensory inputs among a wide population of spinal interneurons in the lower cervical segments. Using low noise intracellular whole cell recordings in the decerebrated, non-anesthetized cat

While many projects have demonstrated the potential of single Nature-based Solutions (NbS) to contribute to urban climate change adaptation, the challenge now lies in moving from demonstration projects to a full-scale deployment. The aim of this research is to assess the potential for a full-scale implementation of NbS in Malmö (Sweden), and the expected benefits and co-benefits. We developed six

The great development of the food industry in the last few years and the increase of the global food trade have highlighted the importance of developing reliable safety assessment and the establishment of strict directives in order to assure its correct performance and the security of consumers. In this sense, the application of nanotechnology has played an important role to carry out very sensiti

We study particle trapping driven by the axial primary radiation force (A-PRF) in shaped traps exposed to standing bulk acoustic waves (S-BAW) using numerical simulations and experiments. The utilization of the stronger A-PRF as the main retention force is a consequence of standing-wave formation along the flow direction, instead of the orthogonal direction as in the case of traditionally used lat

Preterm birth is associated with increased risk of complications, specifically with regards to the gastrointestinal tract. These complications mainly include the maldigestion and malabsorption of nutrients resulting from the immaturity of the small intestine. The current study investigated whether pre-digestion of fat in infant formula would affect the developmental remodeling of the structure of

Objective: Previous research has suggested an association between physical activity (PA), joint function, and molecular biomarkers, but more studies are needed. The aim of this study was to explore the associations between PA or self-reported joint function and molecular biomarkers of cartilage and inflammation in individuals with hip and/or knee osteoarthritis (OA). Specific objectives were to ex

This year marks the inauguration of the annual Editors’ Choice Award and the Readers’ Choice Award, each presented for outstanding original papers and review articles published in the Journal of Comparative Physiology A. The winners of the 2022 Editors’ Choice Award were determined by vote of the Editorial Board for the most highly recommended papers published in Volume 207 in 2021. They are ‘Visu

Vertically oriented graphene (VG) has attracted attention for years, but the growth mechanism is still not fully revealed. The electric field may play a role, but the direct evidence and exactly what role it plays remains unclear. Here, we conduct a systematic study and find that in plasma-enhanced chemical vapor deposition, the VG growth preferably occurs at spots where the local field is stronge

PEPCRE is an interactive computer graphics program for the rapid construction, manipulation and display of oligopeptides. Essentially any desired conformation of an oligopeptide can be constructed in a simple and straightforward manner. The program provides various display and output possibilities. It is user-friendly and is written in FORTRAN 77 for use on inexpensive, monochrome graphics termina

The ESS Neutrino Super-Beam (ESSnuSB) is a proposed long-baseline neutrino oscillation experiment, performed with a high-intensity neutrino beam, to be developed as an extension to the European Spallation Source proton linac currently under construction in Lund, Sweden. The neutrinos would be detected with the near and far detectors of the experiment, the former within several hundred meters of th