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Atrial natriuretic peptide (ANP) represents an attractive therapeutic target in hypertension and heart failure. The biologically active form of ANP is produced by the cardiac serine protease corin, and modulation of its activity might therefore represent a novel approach for ANP augmentation. MicroRNAs (miRNAs) are pervasive regulators of gene expression, but their potential role in regulating cor
Background: Hyperlipidaemia is a major risk factor for cardiovascular disease, and atherosclerosis is the underlying cause of both myocardial infarction and stroke. We have previously shown that the Pro251 variant of perilipin-2 reduces plasma triglycerides and may therefore be beneficial to reduce atherosclerosis development. Objective: We sought to delineate putative beneficial effects of the Pr
Objectives There is an epidemic of Mesoamerican nephropathy (MeN) in Central America, where sugarcane production is prominent. Numerous causes are proposed, but to date limited evidence supports any one hypothesis. A nested case-control study using biosamples from a rural, community-based follow-up study of 350 young adults from Northwest Nicaragua at risk of MeN was conducted with the aim of char
Using a highly comprehensive new data set on Swedish researchers, we investigate the effects of inter-university mobility on researcher productivity. Our study suggests substantial gains from mobility on scientific output. The empirical analysis addresses selection using inverse probability treatment censoring weights. We find that mobility induces a long-lasting increase in a researcher's publica
Acquired angioedema due to C1-inhibitor (C1INH) deficiency (AAE) is caused by secondary C1INH deficiency leading to bradykinin-mediated angioedema episodes. AAE typically presents in adulthood and is associated with B cell lymphoproliferation. Anti-C1INH autoantibodies (antiC1INHAbs) are detectable in a subset of AAE cases and considered a hallmark of the disease. When free antiC1INHAbs and malign
Seventeen cases of infections in spinal structures were reported 2010-2017 to the Swedish Health and Social Care Inspectorate (IVO), a government agency responsible for supervising health care, for missed or delayed diagnosis. All patient records were scrutinized in order to find underlying causes and common factors. The delayed diagnoses were equally found among men and women and most frequent in
2014 publicerades Ett forskningsinstitut växer fram – IUI från grundandet till 1950. I den här boken fortsätter historien om Industriens Utredningsinstitut (numera Institutet för Näringslivsforskning). Den period som behandlas är 1950–66, en period då institutet leddes av dynamiska chefer, Jan Wallander (1953–61) och Ragnar Bentzel (1961–66), och dess ställning som Sveriges ledande fristående fors
Den här studien bidrar med sina resultat till kunskapen kring hur kommuner arbetar med krishantering, ett område som tidigare studier visat kräver mer forskning (Choi och Brower, 2006; Marschall, 2015; Jarman et al., 2000; Mullin och Rubado, 2017). Den här studien bidrar även med kunskap kring hur kommuner kan samverka såväl inom den egna organisationen s
In this study we modeled secondary organic aerosol (SOA) mass loadings from the oxidation (by O3, OH and NO3) of five representative biogenic volatile organic compounds (BVOCs): isoprene, endocyclic bond-containing monoterpenes (
Changes in the latitudinal position and strength of the Southern Hemisphere westerlies (SHW) are thought to be tightly coupled to important climate processes, such as cross-equatorial heat fluxes, Atlantic Meridional Overturning Circulation (AMOC), the bipolar seesaw, Southern Ocean ventilation and atmospheric CO2 levels. However, many un
In computer simulations, long-range electrostatic interactions are surprisingly well approximated by truncated, short-ranged pair potentials. Examples are reaction field methods; the Wolf method; and a number of schemes based on cancellation of electric multipole moments inside a cut-off region. These methods are based on the assumption that the polarization of the neglected surroundings can be in
There is an urgent need for society to find more effective ways to reduce the impact of disastrous events. One way is to proactively increase actors’ response capability. Capability assessments play an essential role in these disaster risk management efforts. Currently, capability is assessed using indicator and index methods that focus on available resources. Such methods may not provide the best
Online routing in a planar embedded graph is central to a number of fields and has been studied extensively in the literature. For most planar graphs no O(1)-competitive online routing algorithm exists. A notable exception is the Delaunay triangulation for which Bose and Morin [Bose and Morin, 2004] showed that there exists an online routing algorithm that is O(1)-competitive. However, a Delaunay
I denna studie analyseras förutsättningarna för att bygga energiberedskap i framtida energisystem. Utgångspunkt tas i Energimyndighetens scenarier "Fyra framtider" och de framtidsutvecklingar av energisystemet och samhället i stort som presenteras i dessa. De områden som studeras särskilt i denna rapport är digitalisering, ökad elektrifiering, decentralisering av elproduktionen, ökat beroende av v
