Sökresultat

Heart failure (HF) is a leading cause of death and disability globally. HF represents the common end- stage of most heart conditions, during which the heart is unable to generate sufficient output of blood for the metabolic demands of the body and intracardiac pressures increase. Different heart diseases display specific molecular pathophysiologies, but common pathways are also present that drive

The effects of defects in In0.47Ga0.53As/Al2O3/Ni metal-oxide-semiconductor (MOS) stacks at cryogenic temperatures are investigated. The MOS stacks exhibit a hysteresis in the capacitance-voltage (CV) curve, both at room temperature and at 100K, indicating the presence of effective charge capture/emission dynamics in the oxide even at cryogenic temperatures. Border traps (BTs) in the Al2O3 close t

New particle formation via the ion-mediated sulfuric acid and ammonia molecular clustering mechanism remains the most widely observed and experimentally verified pathway. Recent laboratory and molecular level observations indicate iodine-driven nucleation as a potentially important source of new particles, especially in coastal areas. In this study, we assess the role of iodine species in particle

Objectives We conducted a focus group to assess the attitudes of primary care physicians (PCPs) toward prostate-specific antigen (PSA)-screening algorithms, perceptions of using decision support tools, and features that would make such tools feasible to implement. Methods A multidisciplinary team (primary care, urology, behavioral sciences, bioinformatics) developed the decision support tool that

Multimorbidity in older people is strongly linked to the need for acute hospital care, and caregiving activities usually become more complex after patients are discharged from hospital. This may negatively impact the health of close family members, although this has not been comprehensively investigated. This study aimed to explore the general and mental health of close family members caring for f

Time-difference-of-arrival (TDOA) estimation from GCC-PHAT is not always as straight forward as finding the maximum peak. This work views the GCC output as an image, with time on the vertical axis and TDOA horizontally, to explore if image-to-image machine learning methods can make a more robust filter. The Structure from Sound Database provides audio recorded with a distributed microphone setup a

Klimatet förändras på ett sätt som gör förlusterna mer påtagliga. Människor och platser i det globala syd vars ekonomier och försörjning på landsbygden är centrerade kring mark och naturresurser anses vara särskilt sårbara för klimatförändringar och förväntas uppleva oproportionerligt stora klimatrelaterade förluster. Bevisen för sådana oproportionerliga bördor och de orättvisor de leder till växeThe climate is changing in ways that make loss more present. People and places in the Global South whose economies and rural livelihoods are centred on land and natural resources are considered particularly vulnerable to climate change and are expected to disproportionately experience climate-related loss. Evidence of such disproportionate burdens and the injustices they engender is growing and ga

Massive multiple-input multiple-output (MIMO) technology will continue playing an important role in beyond 5G wireless systems. Fully digital beamforming at the millimeter wave (mmWave) spectrum enables applications that require high data rates and low latency. This paper investigates the development and deployment of mmWave massive MIMO systems in an in-flight cabin environment, from both system

Whereas cigarette smoking remains the main risk factor for emphysema, recent studies in β-epithelial Na+ channel-transgenic (βENaC-Tg) mice demonstrated that airway surface dehydration, a key pathophysiological mechanism in cystic fibrosis (CF), caused emphysema in the absence of cigarette smoke exposure. However, the underlying mechanisms remain unknown. The aim of this study was to elucidate mec

In order to allow for a computationally efficient estimation of radar reflections, one commonly assumes the reflecting target to be in the far-field of the sensing array, such that the impinging wavefront is modeled as a linear phase-shift along the array. This works well in most radar scenarios, but causes significant performance degradation for close-range radar systems, wherein the curvature of

MMP12 is a metalloproteinase implicated in inflammation. To monitor its activity, we synthesized a membrane-targeted reporter (LaRee1) based on Foerster resonance energy transfer (FRET). Unlike existing sensors, LaRee1 detects MMP12 activity by loss of FRET plus internalization of the lipidated fragment. In bronchoalveolar lavages from a mouse model of pulmonary inflammation, LaRee1 detected MMP12

When Iran directed over 300 missiles and drones at Israel on April 13, Jordan helped fend off the attack. Initial media reports suggested that several other Arab states assisted in Israel’s defense, efforts they later denied. Nonetheless, a chorus of Israeli leaders, as well as some observers in Washington, interpreted these acts as a sign of a major shift. These Arab states, the argument went, wo

Health inequalities are a persistent and growing issue in different countries worldwide. Sweden, despite being one of the scandinavian countries with internationally recognized welfare system is no exception. The issue of health disparities and its increase among some groups, including those who are categorised as migrant have been acknowledged. Emergence of the COVID-19 pandemic, however, reveale

Abstract:Background Type 1 diabetes (T1D) is one of the most common childhood autoimmune diseases, with rising incidence worldwide with a male predominance. The etiology behind the disease is mostly unknown and it is essential to understand the factors that impact its development to prevent the disease and personalize the treatment. This thesis aims to examine sex-specific differences in T1D, expl

BACKGROUND: In the European Union alone, more than 100 million people present to the emergency department (ED) each year, and this has increased steadily year-on-year by 2-3%. Better patient management decisions have the potential to reduce ED crowding, the number of diagnostic tests, the use of inpatient beds, and healthcare costs.METHODS: We have established the Skåne Emergency Medicine (SEM) co

INTRODUCTION: With the implementation of early reperfusion therapy, the number of complications in patients with acute coronary syndrome (ACS) has diminished significantly. However, ACS patients are still routinely admitted to units with high-level monitoring such as the coronary or intensive care unit (CCU/ICU). The cost of these admissions is high and there is often a shortage of beds. The aim o