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Business leaders increasingly face decisions that are not just technical or financial but deeply philosophical. Questions about what a company is for, what counts as reliable knowledge, and what responsibilities organizations owe customers, employees, and society now shape strategy as much as markets or technology. Yet most executives have never been trained to think explicitly about these issues.
This paper presents a joint model of multivariate longitudinal data and multistate data with application to modeling and predicting autoantibody development in The Environmental Determinants of Diabetes in the Young (TEDDY) study. The model quantifies the risks of state transitions based on observed time-varying and non-time-varying risk factors. Based on the estimated model, a dynamic prediction
ABSTRACT: Introduction / Rationale: The idea to facilitate development and learning originated from research engaging children and adults with profound cognitive disabilities in powered wheelchair practice (Driving to Learn). Later elaborations led to the development of the tool Assessment of Learning Process (ALP) including the facilitating approach. Objectives: To increase the understanding of t
Neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) has been the standard care for muscle-invasive bladder cancer (MIBC) for two decades. One third of NAC-treated patients achieve pathologic complete response (pT0N0), a proxy for improved survival after RC. Predicting response already at transurethral resection of bladder tumor (TUR-BT) would enable selective use of NAC, minimizing
Cutaneous T-cell lymphoma is a chronic disease with a highly heterogeneous and unpre-dictable clinical course, and the impact on psychological resilience is still unknown. The primary aim was to investigate psychological resilience in cutaneous T-cell lymphoma patients over time and to relate it to dermatology-related quality of life (QoL) metrics. Psychological investigations were evaluated in 45
PURPOSE: To determine whether Comprehensive Geriatric Assessment (CGA)-based healthcare, delivered by a mobile team over 24 months in patients' homes reduces hospital care or improves quality of life, physical performance, frailty, activities of daily living (ADL), or cognition and whether it reduces mortality or number of hospital admissions.METHODS: Patients ≥ 75 years of age, with ≥ 3 visits to
There is an ongoing shift in the Swedish welfare state, characterised by an increased datafication. The increasing reliance on data as a means of predicting citizens’ behaviour not only transforms the way the welfare state is organised, but also the very notion of welfare. As a response to a growing discussion on inaccurate welfare payments in Sweden, the Swedish Payments Agency (UBM) was establis
BackgroundThe Parkinson's Disease (PD) Home Diary (HD) is a common clinical outcome measure, but studies show only fair agreement between clinical observer and patient assessments, with no significant improvement after patient training.ObjectivesTo investigate the agreement between a clinical observer and relatives of PD patients when assessing the patient's motor status in the HD. Agreement was a
Insufficient interfacial compatibility and inherent flammability of polymer matrices are two critical factors that limit the practical application of basalt fiber–reinforced polymer composites (BFRPs). In this study, an interfacial engineering strategy based on the in situ growth of nano-SiO2 is proposed. DOPO-functionalized linear and cage-like interfacial structures are then constructed on the b
