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Modeling and robust pooling design of a preparative cation-exchange chromatography step for purification of monoclonal antibody monomer from aggregates.

This study has implemented and calibrated a model that describes the separation of the monomer of monoclonal antibodies from the dimer and larger oligomers on preparative-scale using cation-exchange chromatography. A general rate model with temperature dependent diffusion was coupled to a pH- and temperature-dependent steric mass action model. The model was shown to predict the retention of the mo

The Mantle Cell Lymphoma International Prognostic Index (MIPI) is superior to the International Prognostic Index (IPI) in predicting survival following intensive first-line immunochemotherapy and autologous stem cell transplantation (ASCT)

Mantle cell lymphoma (MCL) has a heterogeneous clinical course. The recently proposed Mantle Cell Lymphoma International Prognostic Index (MIPI) predicted the survival of MCL better than the International Prognostic Index in MCL patients treated with conventional chemotherapy, but its validity in MCL treated with more intensive immunochemotherapy has been questioned. Applied here to 158 patients o

Expression of Cocaine- and Amphetamine-Regulated Transcript Is Associated with Worse Survival in Small Bowel Carcinoid Tumors

Purpose: Cocaine-and amphetamine-regulated transcript (CART) peptide exerts several regulatory functions acting both as neurotransmitter and hormone. We recently showed that CART is expressed in various neuroendocrine tumors, including small bowel carcinoids. The main objective of the present study was to examine whether CART expression is associated with survival in patients with small bowel carc

Investigation of Hydrogen Enriched Natural Gas Flames in a SGT-700/800 Burner Using OH PLIF and Chemiluminescence Imaging

The effect of hydrogen enrichment to natural gas flames was experimentally investigated at atmospheric pressure conditions using flame chemiluminescence imaging, planar laser-induced fluorescence of hydroxyl radicals (OH PLIF), and dynamic pressure monitoring. The experiments were performed using a third generation dry low emission (DLE) burner used in both SGT-700 and SGT-800 industrial gas turbi

Low-mass vector-meson production at forward rapidity in p plus p collisions at root s=200 GeV

The PHENIX experiment at the Relativistic Heavy Ion Collider has measured low-mass vector-meson ,omega, rho, and phi, production through the dimuon decay channel at forward rapidity (1.2 < vertical bar y vertical bar < 2.2) in p + p collisions at root s = 200 GeV. The differential cross sections for these mesons are measured as a function of both p(T) and rapidity. We also report the integrated di

Description of the new I1011 beamline for magnetic measurements using synchrotron radiation at MAX-lab

We report on the characterization of the new I1011 beamline at the MAX-II storage ring, in the MAX-lab synchrotron radiation laboratory and give examples of first results. This beamline is using an Elliptically Polarizing Undulator source, producing soft x-rays of a variable polarization state. It delivers high flux and high brightness circularly polarized x-rays in the energy range 0.2 to 1.7 keV

Exact algebraization of the signal equation of spoiled gradient echo MRI

The Ernst equation for Fourier transform nuclear magnetic resonance (MR) describes the spoiled steady-state signal created by periodic partial excitation. In MR imaging (MRI), it is commonly applied to spoiled gradient-echo acquisition in the steady state, created by a small flip angle α at a repetition time TR much shorter than the longitudinal relaxation time T1. We describe two parameter transf

A Low-Latency High-Throughput Soft-Output Signal Detector for Spatial Multiplexing MIMO Systems

This paper presents a low latency, high throughput soft-output signal detector for a 4x4 64-QAM spatial-multiplexing MIMO system. To achieve high data-level parallelism and accurate soft information, the detector adopts a channel-adaptive node perturbation technique to generate a list of candidate vectors around an initial linear estimation. The detection algorithm provides a large range and conve

Fully aromatic block copolymers for fuel cell membranes with densely sulfonated nanophase domains

Two multiblock copoly(arylene ether sulfone)s with similar block lengths and ion exchange capacities (IECs) were prepared by a coupling reaction between a non-sulfonated precursor block and a highly sulfonated precursor block containing either fully disulfonated diarylsulfone or fully tetrasulfonated tetraaryldisulfone segments. The latter two precursor blocks were sulfonated via lithiation-sulfin

The activity of an insectivorous bat Neoromicia nana on tracks in logged and unlogged forest in tropical Africa

Logging activities and the associated creation of roads and tracks can disturb and fragment forests, which may lead to a loss of forest-dependent species and possibly favour nonforest generalists and edge species. The effects of such disturbance are poorly known for African insectivorous bats. We studied the activity patterns of insectivorous bats in a tropical African forest at Kibale National Pa

Effects of Glial Cell Line-derived Neurotrophic Factor on the Cultured Adult Full-thickness Porcine Retina.

Abstract Background: The tissue culture system offers a possibility to study factors involved in neuronal survival which may be important in a transplantation paradigm. The use of adult tissue in this setting poses specific challenges since traditionally mature neurons survive poorly in vitro. In the current paper, we have explored effects of glial cell line-derived neurotrophic factor (GDNF) on c

Preparation of DNA from cytological material: Effects of Fixation, Staining, and Mounting Medium on DNA Yield and Quality.

BACKGROUND: Personalized oncology requires molecular analysis of tumor cells. Several studies have demonstrated that cytological material is suitable for DNA analysis, but to the authors' knowledge there are no systematic studies comparing how the yield and quality of extracted DNA is affected by the various techniques used for the preparation of cytological material. METHODS: DNA yield and qualit

Convexity-preserving flux identification for scalar conservation laws modelling sedimentation

Sedimentation of a suspension of small particles dispersed in a viscous fluid can be described by a scalar, nonlinear conservation law, whose flux function usually has one inflection point. The identification of the flux function is of theoretical interest and practical importance for plant-scale simulators of continuous sedimentation. For a real suspension, the Kynch test and the Diehl test, whic

Exemplification as Explanation

In this paper I critically investigate an unorthodox attempt to metaphysically explain in virtue of what there are states of affairs. This is a suggestion according to which states of affairs exist thanks to, rather than, as is the common view, in spite of, the infinite regress their metaphysical explanation seems to engender. I argue that, no matter in which form it is defended, or in which theor

Applying a palliative care approach in residential care: Effects on nurse assistants' work situation.

Objectives: The aim was to investigate the effects of an intervention that applies a palliative care approach in residential care upon nurse assistants' level of strain, job satisfaction, and view of leadership. Method: A quasi-experimental, pretest and posttest design was used. Study circles with workshops involving nurse assistants (n = 75) and their superiors (n = 9) focusing on emotional and e

Balloon kyphoplasty in patients with osteoporotic vertebral compression fractures

Balloon kyphoplasty (BKP) is a minimally invasive surgical procedure indicated for treatment of painful vertebral compression fractures. During BKP, cannulae are placed percutaneously into the vertebral body, allowing insertion of inflatable balloons. Inflating the balloons partially restores vertebral body height, compacts the bone and creates a cavity for placement of bone cement after balloon r