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An enzymatic process to alpha-ketoglutarate from L-glutamate: the coupled system L-glutamate dehydrogenase/NADH oxidase

alpha-Ketoglutarate, employed to treat mild chronic renal insufficiency, was obtained through enzymatic oxidation of monosodium glutamate (MSG) catalyzed by L-glutamate dehydrogenase (L-gluDH) coupled with NADH oxidase for the regeneration of NADH back to NAD(+). The irreversible reduction of molecular oxygen to water by NADH oxidase is demonstrated to drive oxidation of MSG to alpha-ketoglutarate

Potential and utilization of thermophiles and thermostable enzymes in biorefining

In today's world, there is an increasing trend towards the use of renewable, cheap and readily available biomass in the production of a wide variety of fine and bulk chemicals in different biorefineries. Biorefineries utilize the activities of microbial cells and their enzymes to convert biomass into target products. Many of these processes require enzymes which are operationally stable at high te

Analysis and design of admission control systems in web-server systems

All service control nodes, for example Web sites or Mobile Switching Centers, can be modeled as server systems with one or more servers processing the incoming requests. To avoid overload at the service control node different types of admission control mechanisms are usually implemented. In this paper we discuss, from a control point of view, the modeling of a service control-node. The queue is as

A systematic overview of radiation therapy effects in rectal cancer

A systematic review of radiation therapy trials in several turnout types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for evaluation of the scientific literature are described separately (Acta Oncol 2003; 42: 357-365). This synthesis of the literature on radiation therapy for rectal cancer is based on data from 42 randomized trials and 3 meta-a

Widow inheritance and HIV/AIDS in rural Uganda

Despite current efforts to combat HlV/AlDS through behavioural change, ingrained socio-cultural practices such as widow inheritance in south-western Uganda has not changed. Low education, unemployment, dowry, widows' socioeconomic demands and the inheritor's greed for the deceased's wealth, influence widow inheritance. Voluntary counselling and testing is needed for the widows and their inheritors

Photoinduced electron transfer between a carotenoid and TiO2 nanoparticle

The dynamics of photoinduced electron injection and recombination between all-trans-8'-apo-beta-caroten-8'-oic acid (ACOA) and a TiO2 Colloidal nanoparticle have been studied by means of transient absorption spectroscopy. We observed an ultrafast (similar to360 fs) electron injection from the initially excited S-2 state of ACOA into the TiO2 conduction band with a quantum yield of similar to40%. A

Interaction between localized and extended modes of oxygen in silicon

The interaction between localized and extended vibrational modes in solids is of central importance in understanding how local vibrational modes (LVMs) decay into phonons. In this study, we have investigated interstitial oxygen (O-i) in silicon as a model 'laboratory' for such local-extended mode interactions. Using hydrostatic pressure and infrared spectroscopy, we brought the stretch mode of O-1

Weakly bound neutrons and quadrupole response function in the many-body pair correlation of neutron drip line nuclei

A simplified model of the Hartree-Fock Bogoliubov (HFB) equation with surface-type or volume-type pairing is solved in coordinate space with the correct asymptotic boundary conditions. By using the resulting HFB wavefunctions, the low-energy quadrupole (L = 2) response function is studied for the system with weakly bound s and d neutrons. As the binding energy of the neutrons becomes small or appr

Peripheral effects of PTH are not altered after thyroid surgery in euthyroid patients

Background. We have previously found decreased serum levels of both ionized calcium and 1,25(OH)(2)D and an increase in serum phosphate levels at 1 year after hemithyroidectomy. However, basal and stimulated parathyroid hormone (PTH) secretions were not altered. To investigate whether the observed biochemical changes after unilateral thyroid surgery may be due to a relative end-organ resistance to

Forging an Incarnational Theology Two Score Years after Nostra Aetate

Surveying how Christology is formulated in the wake of Nostra Aetate, this paper concentrates on three models: (1) The man became words, words, words; the quest for the historical Jesus has often emphasised the — allegedly unique — teachings of the Nazarene. Its main problem, however, is that the contemporaries of Jesus are no longer presented as his historical context but as his theological contr

Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond

Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute attacks of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to intra-abdominal edema. Resulting from mutations affecting C1 esterase inhibitor (C1-INH), inhibitor of the first complement system component, attacks are not histamine-mediated and do not respond to antihistamines or cor