In hospitals, IV bags can be prepared in advance for logistical and microbial safety reasons in a compounding unit and then transported to wards. Transport of protein drugs using a pneumatic tube system has been reported to result in high particle levels. In this study, pneumatic tube transport of trastuzumab in saline polyolefin bags was compared to delivery by hospital porters using an electric

Protein drugs, such as therapeutic antibodies, are complex and require careful handling to maintain their efficacy and quality. Stress factors in hospitals, like temperature variations and mechanical shocks during transport, may negatively impact the stability of protein drugs (e.g. various monoclonal antibodies). The pharmaceutical industry possesses extensive knowledge about their product formul

This study reveals specific ion effects on particle formation during peristaltic pumping of a monoclonal Antibody (Antibody A). For this purpose, three anions in the direct Hofmeister series were selected, ranging from the kosmotropic SO42- to the more neutral Cl- and the chaotropic SCN-. Protein particle formation during peristaltic pumping is described primarily as a surface-driven mechanism. Th

Biological drugs intended for multidose use normally contain both preservatives and non-ionic surfactants. However, most common preservatives and surfactants in parenteral formulations are considered to be physically incompatible with each other. In this study, the phase separation of polysorbate 20 and polysorbate 80 in the presence of phenolic preservatives is systematically mapped. The observed

This study explores how Swedish preachers incorporate AI chats such as ChatGPT into sermon preparation. Based on interviews, chat logs, and sermon manuscripts from six priests in the Church of Sweden, the study uses relevance theory to analyse the preachers' prompting and evaluation strategies. The preachers primarily use large language models (LLMs) for brainstorming and inspiration, critically eThis study explores how Swedish preachers incorporate AI chats such as ChatGPT into sermon preparation. Based on interviews, chat logs, and sermon manuscripts from six priests in the Church of Sweden, the study uses relevance theory to analyse the preachers' prompting and evaluation strategies. The preachers primarily use large language models (LLMs) for brainstorming and inspiration, critically e

This study investigates seasonal changes in near-surface wind speeds in the Arctic using the regional climate model (RCM) simulations with RCA4 driven by four global climate models (GCMs) CMIP5 under Representative Concentration Pathways (RCP) 4.5 and 8.5 scenarios. In addition, the RCM RCA-GUESS (RCA4 with interactive vegetation dynamics) is used to investigate the role of biogeophysical feedback

Due to ongoing climate change, methane (CH4) emissions from vegetated wetlands are projected to increase during the 21st century, challenging climate mitigation efforts aimed at limiting global warming. However, despite reports of rising emission trends, a comprehensive evaluation and attribution of recent changes remains limited. Here we assessed global wetland CH4 emissions from 2000-2020 based

Recovery time, referring to the duration that an ecosystem needs to return to its pre-drought condition, is a fundamental indicator of ecological resilience. Recently, flash droughts – characterised by rapid onset and development – have gained increasing attention. Nevertheless, the spatiotemporal patterns in gross primary productivity (GPP) recovery time and the factors influencing it remain larg

BACKGROUND: Statins have been suggested to protect against breast cancer risk, but the observational evidence is inconclusive. We examined the association between statin use and breast cancer incidence among women at higher risk of breast cancer due to a history of benign breast disease (BBD).METHODS: Using Danish registries, we identified cancer-free women aged ≥50 years during 1996-2018 with a h

Europe is confronted with a multiple crisis while coming to grips with its colonial legacy. Given the lack of empirical evidence for sufficient absolute decoupling of gross domestic product (GDP) growth from environmental resource use to stay within planetary limits and meet the Paris climate goals, this article argues that it is unavoidable for the European Union (EU) to enter the postgrowth era

OBJECTIVE: This study evaluated the effects of a 6-week osteoarthritis (OA) exercise and education intervention on metabolic health markers, including blood pressure (BP), glycated haemoglobin (HbA1c), high-density lipoprotein (HDL), cholesterol levels and weight in individuals with both OA and diabetes.METHODS: Data originated from the Swedish Osteoarthritis and Diabetes cohort, which is composed

This article examines how different layers of health-related uncertainties emerge and intersect in an algorithmic society. We aim to understand how people’s self-care practices co-evolve with digitalised health systems. Sweden stands out among Western countries due to the population’s high digital consumption of medical and health products. We conceptualise health-related uncertainties as inherent

Patientrörelsen behövs på alla nivåer i kommuner och regioner. Det ställer enorma krav på kompetensförsörjningen, skriver debattörer från bland annat Centrum för personcentrerad vård.

Cultural citizenship suggests that people negotiate what it means to be a citizen and belong to a nation. Social media is an online space where women can practise citizenship, where the sense of belonging and norms of what it means to be a citizen are negotiated. This study explored how women in the United Arab Emirates use social media as a public space for negotiating an Emirati identity. Focus

Traditionally, traffic safety is expressed through the number of accidents (crashes) or people injured, since these are the most direct manifestations of an unsafe traffic environment. As we discuss in this chapter, such an approach has its limitations due to the low frequency of accidents and some other issues. Neither is it unusual that accident data is not available, not reliable or lacks impor

In this chapter, we will discuss the limitations of police accident data and the added value of health data as a complementary source. Several types of health organisations exist that cover a certain severity of traffic casualties. A number of medical indicators will be discussed, as well as methods to estimate the true number of serious injuries and the completeness of the police reporting. For t