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A nephritogenic peptide induces intermolecular epitope spreading on collagen IV in experimental autoimmune glomerulonephritis

This group previously identified a peptide p13 of alpha 3(IV)NC1 domain of type IV collagen that induces experimental autoimmune glomerulonephritis (EAG) in rats with generation of antibodies to sites on alpha 3(IV)NC1 external to the peptide as a result of intramolecular epitope spreading. It was hypothesized that intermolecular epitope spreading to other collagen IV chains also was induced. Rats

Ultrafast opto-terahertz photonic crystal modulator

We present an agile optically controlled switch or modulator of terahertz (THz) radiation. The element is based on a one-dimensional photonic crystal with a GaAs wafer inserted in the middle as a defect layer. The THz electric field is enhanced in the photonic structure at the surfaces of the Ga-As wafer. Excitation of the front GaAs surface by ultrashort 8 10 nm laser pulses then leads to an effi

Cadmium accumulation and Salix-based phytoextraction on arable land in Sweden

Cadmium accumulation in arable soils causes concern due to possible direct environmental effects and health risks associated with exposure of humans to cadmium through agricultural products. This paper discusses the problem of cadmium accumulation in Swedish arable land, and evaluates Salix (Salix vinimalis) cultivation as a tool for addressing the problem. It is found that Salix cultivation offer

Alkaline sphingomyelinase: An old enzyme with novel implications.

Alkaline sphingomyelinase (alk-SMase) is present in the intestinal tract and additionally human bile. It hydrolyses sphingomyelin in both intestinal lumen and the mucosal membrane in a specific bile salt dependent manner. The enzyme was discovered 36 years ago but got real attention only in the last decade, when sphingomyelin metabolism was realized to be a source of multiple lipid messengers, and

Effects of dehydroepiandrosterone supplement on health-related quality of life in glucocorticoid treated female patients with systemic lupus erythematosus

The objective of this study was to evaluate the efficacy of low dose dehydroepiandrosterone (DHEA) on health-related quality of life (HRQOL) in glucocorticoid treated female patients with systemic lupus erythematosus (SLE). Forty one women (>= 5 mg prednisolone/day) were included in a double-blind, randomized, placebo-controlled study for 6 months where DHEA was given at 30 mg/20 mg (= 46 years) d

Degradation of toxaphene by Bjerkandera sp. strain BOL13 using waste biomass as a cosubstrate

The white-rot fungus Bjerkandera sp. strain BOL13 was capable of degrading toxaphene when supplied with wood chips, wheat husk or cane molasses as cosubstrates in batch culture experiments. Approximately 85% of toxaphene was removed when wheat husk was the main substrate. The production of lignin peroxidase was only stimulated when wheat husk was present in the liquid medium. Although xylanase was

The Swedish Council on Technology Assessment in Health Care (SBU) systematic overview of radiotherapy for cancer including a prospective survey of radiotherapy practice in Sweden 2001 - Summary and conclusions

A systematic assessment of radiotherapy for cancer was conducted by The Swedish Council on Technology Assessment in Health Care (SBU) and published in 1996. The assessment reviewed the scientific literature up to 1993 on the use of radiotherapy in the treatment of solid tumours. and estimated the costs associated with radiotherapy It also described the current practise of radiotherapy in Sweden 19

Human endogenous retrovirus family HERV-K(HML-5): Status, evolution, and reconstruction of an ancient betaretrovirus in the human genome

The human genome harbors numerous distinct families of so-called human endogenous retroviruses (HERV) which are remnants of exogenous retroviruses that entered the germ line millions of years ago. We describe here the hitherto little-characterized betaretrovirus HERV-K(HML-5) family (named HERVK22 in Repbase) in greater detail. Out of 139 proviruses, only a few loci represent full-length proviruse

In vitro sliding of actin filaments labelled with single quantum dots

We recently refined the in vitro motility assay for studies of actomyosin function to achieve rectified myosin induced sliding of actin filaments. This paves the way, both for detailed functional studies of actomyosin and for nanotechnological applications. In the latter applications it would be desirable to use actin filaments for transportation of cargoes (e.g., enzymes) between different predet

On methods for pattern recognition with application to epileptic electroencephalograms

Popular Abstract in Swedish Elektroencefalogrammet (EEG), dvs mätning av potentialer på skalpen, är en relativt enkel och gammal teknik för att studera hjärnans aktivitet. Trots de stora framstegen inom s k brain-mapping-tekniker på senare år (magnetröntgen, PET, SPECT), är EEG fortfarande ett viktigt verktyg för diagnos. En av dess fördelar gentemot andra tekniker är dess fina tidsupplösning. EtThe thesis treats methods for pattern recognition in multichannel electroencephalogram (EEG) signals, for application to diagnostics of epilepsy. Parts I-IV treat methods for feature extraction and clustering of EEG spikes, occurring between epileptic seizures, and part V presents a method for filtering seizure onset EEG signals. In part I, Hermite functions are used for parametric description of