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Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy

α-Synucleinopathies are characterized by autonomic dysfunction and motor impairments. In the pure autonomic failure (PAF), α-synuclein (α-Syn) pathology is confined within the autonomic nervous system with no motor features, but mouse models recapitulating PAF without motor dysfunction are lacking. Here, we show that in TgM83+/− mice, inoculation of α-Syn preformed fibrils (PFFs) into the stellate

Social learning towards a more adaptive paradigm? Reducing flood risk in Kristianstad municipality, Sweden

Social learning is often treated as an intervention, a designed process facilitated or even initiated by a third party. We investigated how a social learning process emerged spontaneously from inside Kristianstad, one of the most flood-prone municipalities in Sweden. Twenty key persons were interviewed over 8 years, many of them several times, to assess the process. A small action oriented group o

How Civil Resistance Succeeds (or Not): Micro-dynamics of Unity, Timing, and Escalatory Actions

The article analyzes the micro‐sociological dynamics of civil resistance in the uprisings in Bahrain and Tunisia (2010‐11). It argues that the Tunisian uprising succeeded because regime repression generated solidarity and unity among diverse groups in society, while the regime increasingly suffered from miscommunication, mistrust, and increasing disobedience. In Bahrain, the movement initially enj

Micro-Dynamics of Repression: How Interactions between Protesters and Security Forces Shaped the Bahraini Uprising

The article applies a micro-sociological approach to investigate civil-military relations in a very concrete form: How do interactions between protesters and security forces shape the development of a conflict? Based on fieldwork in Bahrain and interviews with activists, journalists and opposition politicians, the article analyses the micro-sociological dynamics of how, despite great numbers and m

Kardiovaskulär sjukdom och diabetes typ II som riskfaktorer för kognitiv sjukdom

En kort sammanställning i tidningen Neurolog i Sverige av våra två artiklar som presenterar prevalensen av kardiovaskulär sjukdom och typ 2 diabetes i olika kognitiva sjukdomar. Här visar vi att Alzheimer's sjukdom och Lewykroppssjukdom, de två vanligaste neurodegenerativa sjukdomarna, har en signifikant lägre förekomst av både kardiovaskulär sjukdom och typ 2 diabetes jämfört med vaskulär demens.Here we presented a review of our two articles presenting the prevalence of cardiovascular disease and diabetes in neurocognitive disorders; Alzheimer's disease, vascular dementia, mixed dementa and Lewy body disease. Cardiovascular disease and diabetes showed a significantly lower prevalence among cases with Alzheimer's disease and Lewy body disease, both neurodegenerative disorders, compared to

A Human Rights Appraisal of the Limits to Judicial Independence for International Criminal Justice

The UN Security Council's involvement in the area of international criminal justice raises concerns about judicial independence. Of primary concern in this study is the degree to which this political organ has come to determine and restrict jurisdiction of international criminal tribunals, with the effect of excluding cases involving alleged grave crimes by actors whose presence in situations of w

Phenomenology in multi-scalar extensions of the Standard Model

Denna sammanläggningsavhandling består av fyra artiklar, som alla berör olika utvidgningar av Standardmodellen (SM). De första två artiklarna behandlar en specifik, supersymmetrisk, storförenad teori (GUT), medan de senare två klassificerar alla anomali-fria instanser av 2-Higgs-dubblett modeller (2HDMs) med en gauge:ad abelsk symmetri. Artikel I. I denna artikel presenterar vi en alternativ lösniThis thesis is composed of four papers, which all treat various extensions to the Standard Model (SM). The first two papers concern a particular supersymmetric, grand-unified theory (GUT), while in the latter two, we classify anomaly-free implementations of two-Higgs doublet models (2HDM) with a gauged abelian symmetry. Paper I. In this paper, we present an alternative solution for avoiding GUT-sc