Conventional social mobility research misses substantial inequalities of opportunity. To capture intergenerational persistence of family social status we need to move beyond parent-child associations in occupation or income. Models that incorporate surname group belonging show that families do not regress to a population mean at the speed implied by parent-child associations. Their mobility is fur

Coherent nonlinear spectroscopies and imaging in the X-ray domain provide direct insight into the coupled motions of electrons and nuclei with resolution on the electronic length scale and timescale. The experimental realization of such techniques will strongly benefit from access to intense, coherent pairs of femtosecond X-ray pulses. We have observed phase-stable X-ray pulse pairs containing mor

PMCA4 is a critical regulator of Ca2+ homeostasis in mammalian cells. While its biological and prognostic relevance in several cancer types has already been demonstrated, only preclinical investigations suggested a metastasis suppressor function in melanoma. Therefore, we studied the expression pattern of PMCA4 in human skin, nevus, as well as in primary and metastatic melanoma using immunohistoch

Enhanced warming in the Arctic (Arctic amplification, AA) in the last decades has been linked to several factors including sea ice and the Atlantic Multidecadal Oscillation (AMO). However, how these factors contributed to AA variations in a long-term perspective remains unclear. By reconstructing a millennial AA index combining climate model simulations with recently available proxy data, this wor

Objective:To determine viral load (VL) nonsuppression (VLN) rates, HIV drug resistance (HIVDR) prevalence, and associated factors among female sex workers (FSWs) in Ethiopia.Methods:A cross-sectional biobehavioral survey was conducted among FSWs in 11 cities in Ethiopia in 2014. Whole blood was collected, and HIVDR genotyping was performed. Logistic regression analysis was performed to identify fa

Understanding the dynamics of stability and change is key to accelerate sustainability transitions. This paper aims to advance and inspire sustainability transition research on this matter by collecting insights from interpretative environmental discourse literature. We develop a heuristic that identifies and describes core discursive elements and dynamics in a socio-technical system. In doing so,

DNA carries the genetic code of life, with different conformations associated with different biological functions. Predicting the conformation of DNA from its primary sequence, although desirable, is a challenging problem owing to the polymorphic nature of DNA. We have deployed a host of machine learning algorithms, including the popular state-of-the-art LightGBM (a gradient boosting model), for b

Background and Purpose: The evolution of total brain volume early after stroke is not well understood. We investigated the associations between age and imaging features and brain volume change in the first month after stroke. Methods: We retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial. Total brain volume change from hyperacute MRI data to the first month af

Background: Acute myeloid leukemia (AML) patients have limited effect from T-cell-based therapies, such as PD-1 and CTLA-4 blockade. However, recent data indicate that AML patients with TP53 mutation have higher immune infiltration and other immunomodulatory therapies could thus potentially be effective. Here, we performed the transcriptional analysis of distinct T-cell subpopulations from TP53-mu

Det här dokumentet ger lokala politiker och tjänstemän ett processorienterat verktyg för att stärka förankringen (integreringen) av ekosystembaserad klimatanpassning i relevanta sektorer av kommunal verksamhet. Guiden presenterar systematiskt de nivåer och områden där förankring av ekosystembaserad klimatanpassning är viktigt, och möjliggör på så sätt planering och bedömning av åtgärder. Det övergThis guideline offers local government officers and local politicians process‐oriented assistance for integrating ecosystem‐based adaptation within relevant sectors of municipal administration with the aim of fostering sustainable urban development. It is thus an instrument to support leadership of this integration process. The levels and areas where integration of ecosystem‐based adaptation isrel

Perhaps the most fundamental question of epistemology asks on what grounds our knowledge of the world ultimately rests. The traditional Cartesian answer is that it rests on indubitable facts arrived at through rational insight or introspection. Coherentists reject this answer, claiming instead that knowledge arises from relations of coherence or mutual support: if our beliefs cohere, we can be sur

Cutibacterium is a genus often considered a contaminant when present in blood cultures, but it can also cause severe infections, especially related to implanted foreign materials. We investigated the incidence and features of patients with true Cutibacterium infection. Patients with positive Cutibacterium blood cultures between the years 2015-2020 in southern Sweden were identified through microbi

Heterostructure engineering in III-V vertical nanowire (VNW) MOSFETs enables tuning of transconductance and breakdown voltage. In this work, an InxGa 1−x As channel with a Ga-composition grading ( x= 1–0.4) in the channel and drain region, combined with field plate engineering, enables breakdown voltage above 2.5 V, while maintaining transconductance of about 1 mS/ μm , in VNW MOSFETs. The field p

Objectives The primary aim of the present study was to investigate the putative excess mortality by suicide in suicide attempters. As a secondary aim, we investigate excess mortality in specific, clinically relevant subgroups: individuals with repeated suicide attempts (RA); individuals who used violent method at the attempt (VA); and those who scored high on the Suicide Intent Scale (HS) at the t