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Effects of simvastatin on apolipoprotein M in vivo and in vitro.

OBJECTIVE: To investigate effects of lipid lowering drug, simvastatin, on apolipoprotein M expression in the hyperlipidemic mice and in hepatic cell line, HepG2 cells. METHODS: Swiss male mice were randomly divided into the high fat group and control group, and were intragastrically fed with 0.9% saline (control group) or lipid emulsion (high fat group) at the daily dosage of 15 ml/kg body weight

High-grade localized metasomatic alteration of the granitic gneiss surrounding a clinopyroxene-rich pegmatoid dyke: Sondrum stenhuggeriet, Halmstad, SW Sweden

The Sondrum stone quarry (Halmstad, SW Sweden) exposes a transition from migmatized granitic gneissic country rock into a foliated clinopyroxene-free granitic gneiss, and then a central pegmatoid dyke dominated by clinopyroxene megacrysts. This transition zone represents a fracture-controlled, fluid-alteration zone that developed under conditions of 650-700 degrees C and 790MPa. Mineral chemical t

Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing

Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited. Here we present a detailed phylogeny based on whole-genome sequencing of representative strains of C. trachomatis from both trachoma and lymphogranuloma venereum (LGV

Automatic registration of multi-modal microscopy images for integrative analysis of prostate tissue sections

Background Prostate cancer is one of the leading causes of cancer related deaths. For diagnosis, predicting the outcome of the disease, and for assessing potential new biomarkers, pathologists and researchers routinely analyze histological samples. Morphological and molecular information may be integrated by aligning microscopic histological images in a multiplex fashion. This process is usually

Acidogenic fermentation of industrial wastewaters: Effects of chemostat retention time and pH on volatile fatty acids production

Acidogenic fermentation of wastewater can serve as a first step in a process for mixed culture production of polyhydroxyalkanoates (PHA) since the produced volatile fatty acids (VFA) are preferred substrates for PHA production. Acidogenic fermentation of industrial wastewaters (cheese whey permeate and three pulp and paper mill effluents) was evaluated in batch and continuous experiments. From the

Drug survival on TNF inhibitors in patients with rheumatoid arthritis comparison of adalimumab, etanercept and infliximab

Objective To compare drug survival on adalimumab, etanercept and infliximab in patients with rheumatoid arthritis (RA). Methods Patients with RA (n=9139; 76% women; mean age 56 years) starting their first tumour necrosis factor (TNF) inhibitor between 2003 and 2011 were identified in the Swedish Biologics Register (ARTIS). Data were collected through 31 December 2011. Drug survival over up to 5 ye

Patients presenting at the emergency department with acute abdominal pain are less likely to be admitted to inpatient wards at times of access block: a registry study.

Also known as access block, shortage of inpatient beds is a common cause of emergency department (ED) boarding and overcrowding, which are both associated with impaired quality of care. Recent studies have suggested that access block not simply causes boarding in EDs, but may also result in that patients are less likely to be admitted to the hospital from the ED. The present study's aim was to inv

Constraining age distributions of groundwater from public supply wells in diverse hydrogeological settings in Scania, Sweden

Twenty-five public supply wells throughout the hydrogeologically diverse region of Scania, Southern Sweden are subjected to environmental tracer analysis (3H–3He, 4He, CFCs, SF6 and for one well only also 85Kr and 39Ar) to study well and aquifer vulnerability and evaluate possibilities of groundwater age distribution assessment. We find CFC and SF6 concentrations well above solubility equilibrium

Local atomic structure around Mn ions in GaN:Mn thin films: Quantitative XANES analysis

GaN:Mn dilute magnetic semiconductors with zinc-blende type of lattice and room temperature ferromagnetism were investigated by the X-ray absorption near edge structure (XANES) with a high accuracy approach of the multidimensional interpolation, which makes it possible to determine the nanoscale local atomic structure around Mn impurities. It is found that Mn atoms are substantially incorporated i

Morphological and electronic properties of epitaxial graphene on SiC

We report on the structural and electronic properties of graphene grown on SiC by high-temperature sublimation. We have studied thickness uniformity of graphene grown on 4H-SiC (0 0 0 1), 6H-SiC (0 0 0 1), and 3C-SiC (1 1 1) substrates and investigated in detail graphene surface morphology and electronic properties. Differences in the thickness uniformity of the graphene layers on different SiC po

Inflammatory biomarkers in serum in subjects with and without work related neck/shoulder complaints

Background: Although it has recently been recognised that inflammation is important in the development of work-related musculoskeletal disorders (MSDs), the exact pathophysiological pathways are unknown. Methods: We investigated serum concentrations of inflammatory cytokines in 35 female supermarket cashiers with repetitive work tasks and work related neck/shoulder complaints, compared with those

Verktyg för optimering av byggtorkning

För att bättre kunna kostnadsoptimera byggtorkningar har ett optimeringsverktyg innefattande ett antal olika beräknings och bedömningsparametrar tagits fram. Byggtorkning innefattar stora kostnader för energi, provisorier och kontroller. Vid misslyckade byggtorkningar adderas det ytterligare kostnader via fuktskador samt ökade omkostnader på grund av byggtorkningar som drar ut på tiden. Alternativ

EBF1 is essential for B-Lineage priming and establishment of a transcription factor network in common lymphoid progenitors

Development of B-lymphoid cells in the bone marrow is a process under strict control of a hierarchy of transcription factors. To understand the development of a B-lymphoid-restricted functional network of transcription factors, we have investigated the cell autonomous role of the transcription factor EBF1 in early B cell development. This revealed that even though transplanted EBF1-deficient fetal

The Armenian Genocide of 1915 from a Neutral Small State’s Perspective : Sweden

This study depicts how the Armenian massacres in the Ottoman Empire during World War I were perceived by a neutral small state, namely, Sweden. The Swedish knowledge should be of special interest since, as a neutral state during the entire conflict, Sweden had no immediate involvement or interest in the ongoing conflict; thus, any reporting about the events would have been untainted compared to th

Energy considerations for a SSF-based softwood ethanol plant

Ethanol can be produced from softwood by steam pretreatment followed by simultaneous saccharification and fermentation (SSF). However, the final ethanol concentration in the SSF step is usually rather low (around 4 wt%) and as a result the energy demand in the downstream processing will be high. In an effort to reduce the energy consumption various alternatives for the downstream processing part o

Validation of ACG Case-mix for equitable resource allocation in Swedish primary health care

Background: Adequate resource allocation is an important factor to ensure equity in health care. Previous reimbursement models have been based on age, gender and socioeconomic factors. An explanatory model based on individual need of primary health care (PHC) has not yet been used in Sweden to allocate resources. The aim of this study was to examine to what extent the ACG case-mix system could exp