Markers of downstream events are a key component of clinical trials of disease-modifying therapies for Alzheimer's disease. Morphological metrics like cortical thickness are established measures of atrophy but are not sensitive enough to detect amyloid-beta (Aβ)- related changes that occur before overt atrophy become visible. We aimed to investigate to what extent diffusion MRI can provide sensiti

The novel wave-shaped bowl piston geometry design with protrusions has been proved in previous studies to enhance late-cycle mixing and therefore significantly reduce soot emissions and increase engine thermodynamic efficiency. The wave-shaped piston is characterized by the introduction of evenly spaced protrusions around the inner wall of the bowl, with a matching number with the number of inject

Market-based climate policies have received increased attention, making it important to understand how such politically created markets affect competition in the electricity market. This paper focuses on the green certificate policy which financially supports producers of renewably sourced electricity by means of tradable certificates, and develops a simple duopoly model that incorporates both the

Clustered regulatory interspaced short palindromic repeats (CRISPR) has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last decade. In the study of cancer, the CRISPR/CRISPR-associated protein (Cas) system opens new avenues into issues that were once unknown in our knowledge of the noncoding genome, tumor heterogeneity, and pr

The purpose of this paper is to explore the perceptions of healthcare professionals (HCPs) in the countries of India and Pakistan, that impede knowledge management practices by adopting mobile technologies in healthcare. An exploratory study was conducted among healthcare professionals in India and Pakistan to assess their perceptions regarding knowledge management practices using mobile applicati

The Preaching Maids in 18th Century Sweden: medical and theological conceptions of supernatural fast, enthusiasm and possession. This thesis examines the relationship between medicine and theology in 18th century Sweden through supernatural fast, enthusiasm (svärmeri) and possession, three terms that all encompass religiously understood diseases. In the thesis these conditions are interpreted as b

Carbon nanotubes (CNTs) are fascinating structures with a wide range of applications and several methods have been developed for their fabrication. The arc-discharge in liquid method is a new technique for synthesis of nanocarbon structures and is recognized as a low-cost method. In this work, this method was used for fabrication of carbon nanotubes, and subsequently a modified acid treatment meth

Bridging the gap between international relations and comparative politics, this book transposes Eurocentric theories and narratives of state-making to new historical and geographical contexts in order to probe their scope conditions. In doing this, the authors question received explanations of the historical origins and geographical limits of state-making, questioning the unilinear view of the eme

The biotechnology industry has recently been demanding nanoparticulate products (20-200 nm) such as viruses, plas-mids, virus-like particles and drug delivery assemblies. Fluid-ized bed/expanded bed adsorption (EBA) is a technique that can be employed for nanoparticulate purification providing practical advantages such as the potential for direct process integration as has been seen with protein p

The theory of capitalist urbanization posits that the built form serves as a crucial sink through which overaccumulated capital is ‘switched' from industrial production into long-term investment in urban infrastructure. Since Harvey's (1978) deployment of the theory, researchers have attempted to empirically substantiate the switching thesis with limited success. Christophers (2011) revisited the

The perovskite-inspired Cu2AgBiI6 (CABI) material has been gaining increasing momentum as photovoltaic (PV) absorber due to its low toxicity, intrinsic air stability, direct bandgap, and a high absorption coefficient in the range of 105 cm−1. However, the power conversion efficiency (PCE) of existing CABI-based PVs is still seriously constrained by the presence of both intrinsic and surface defect

A one-step sandwich chemiluminescence immunometric assay (LIA) was developed for the quantification of bifunctional peptidylglycine-α-amidating monooxygenase (PAM) in human plasma (PAM-LIA). PAM is responsible for the activation of more than half of known peptide hormones through C-terminal α-amidation. The assay employed antibodies targeting specific catalytic PAM-subunits, peptidylglycine alpha-

Antimony-based perovskite-inspired materials (PIMs) are solution-processable halide absorbers with interesting optoelectronic properties, low toxicity, and good intrinsic stability. Their bandgaps around 2 eV make them particularly suited for indoor photovoltaics (IPVs). Yet, so far only the fully inorganic Cs3Sb2ClxI9−x composition has been employed as a light-harvesting layer in IPVs. Herein, th

Objective: Externally applied abduction and rotational loads are major contributors to the knee joint injury mechanism; yet, how muscles work together to stabilize the knee against these loads remains unclear. Our study sought to evaluate lower limb functional muscle synergies in healthy young adults such that muscle activation can be directly related to internal knee joint moments. Methods: Conca

The insertion of a silent period (or gap) in a frequently occurring standard stimulus elicits a negative-going event-related potential (ERP), called the Deviant-Related Negativity (DRN). This is often studied using a single-deviant paradigm. To study the effects of gaps with multiple durations, a different sequence would be required for each gap. A more time-efficient multi-deviant paradigm has be

Anterior cruciate ligament injury (ACLi) reduces mechanical knee joint stability. Differences in muscle activation patterns are commonly identified between ACLi individuals and uninjured controls (CON); however, how and which of these differences are adaptations to protect the knee or adversely increase risk of joint instability remain unclear. Since the neuromuscular system integrates activity of

The role of muscle activation in both pathological and spastic populations is of interest for understanding central nervous system function. Muscle activation patterns may provide insight into pathological changes compared to healthy controls. To gain a better understanding of surgical interventions, gait muscle activation patterns are studied before and after surgery. Previous studies using surfa

The complexity of human tibiofemoral joint motion is now better understood with the advancement of new methodologies to measure tibiofemoral kinematics in vivo. Marker clusters anchored to stainless steel bone pins inserted directly into the femur and tibia provide the most sensitive and accurate means for directly measuring skeletal tibiofemoral joint motion. Despite its invasiveness, this techni

In this work, we introduce P3HT (poly(3-hexylthiophene-2,5-diyl)) as an efficient hole transport material (HTM) for lead-free Cs3Sb2I9perovskite-inspired solar cells. The P3HT doubles the power conversion efficiency (PCE) of the solar cells (PCE = 2.5% for the champion device) by improving all of the figures of merit: the fill factor, open-circuit voltage, and the short-circuit current. The maximu