Here we report large-amplitude transit timing variations (TTVs) for AU Microcopii b and c as detected in combined TESS (2018, 2020) and CHEOPS (2020, 2021) transit observations. AU Mic is a young planetary system with a debris disk and two transiting warm Neptunes. A TTV on the order of several minutes was previously reported for AU Mic b, which was suggested to be an outcome of mutual perturbatio

In this work we propose and analyze an HDG method for the Stokes equation whose domain is discretized by two independent polygonal subdomains with different meshsizes. This causes a non-conformity at the intersection of the subdomains or leaves a gap (unmeshed region) between them. In order to appropriately couple these two different discretizations, we propose suitable transmission conditions to

Recently there have been tremendous efforts to develop statistical procedures which allow to determine subgroups of patients for which certain treatments are effective. This article focuses on the selection of prognostic and predictive genetic biomarkers based on a relatively large number of candidate Single Nucleotide Polymorphisms (SNPs). We consider models which include prognostic markers as ma

Background: Metabolite profiles provide snapshots of the overall effect of numerous exposures accumulated over life courses, which may lead to health outcomes in the future. Objective: We hypothesized that the risk of all-cause mortality is linked to alterations in metabolism earlier in life, which are reflected in plasma metabolite profiles. We aimed to identify plasma metabolites associated with

Multipliers of reproducing kernel Hilbert spaces can be characterized in terms of positivity of n n matrices analogous to the classical Pick matrix. We study for which reproducing kernel Hilbert spaces it suffices to consider matrices of bounded size n. We connect this problem to the notion of subhomogeneity of non-selfadjoint operator algebras. Our main results show that multiplier algebras of ma

Local feature matching is a critical part of many computer vision pipelines, including among others Structure-from-Motion, SLAM, and Visual Localization. However, due to limitations in the descriptors, raw matches are often contaminated by a majority of outliers. As a result, outlier detection is a fundamental problem in computer vision and a wide range of approaches, from simple checks based on d

Visibility across supply chains has been a key concern for organisations for many years, but the tools and information systems to achieve real-time visibility have not been available until recently. In response to uncertainty and complexity, advanced information and communication technologies have been explored for supply chain visibility (SCV). However, managerial perspectives are largely absent

This article presents the results of survey-based research which explores if licensed aircraft maintenance engineers working in Norway, Sweden, and Portugal experience regulated “just culture” as procedural justice-infused processes when occurrence reporting in European Union (EU) civil aviation. Drawing on Tylerian procedural justice theory, the study finds that, perceived procedural justice is m

The purpose of this paper is to simplify the standard framework integrating epidemiological and economic concerns. We present a model where a social planner can influence the spread-intensity of an infection wave through a single parameter. The spread-intensity affects both economic activity and population health. We study the planner's optimal trade-off between upholding economic activity and pre

The purpose of this study is to examine how teachers’ PCK is expressed in science teaching practice, both from a teacher’s and a student’s perspective. It is a qualitative study of three teachers’ physics classroom lectures in grades 7 and 8. International research has highlighted the impact of teachers on students’ achievement in general and in science education in particular, and several ongoing

Temperature and coagulant types have an important impact on the quantity and quality of the residue (sludge) in water and wastewater treatment processes. Temperature influences water viscosity and the distribution of the coagulant in water. Coagulants can promote the agglomeration of fine particles into larger flocs so that they can be more easily separated from the water. Experiments have been co

Background: A new, supposedly more reproducible radiographic classification, set to replace the Tönnis classification of hip dislocations, was proposed in 2015: the International Hip Dysplasia Institute (IHDI) classification. Purpose: To compare the IHDI classification with the Tönnis classification when evaluating the severity of hip dislocations as well as their respective inter- and intra-obser

This chapter examines the nature of the interaction between the Georgian Orthodox Church (GOC) and the state during the pandemic. The article shows how the church’s gradual acknowledgment of the deadly character of the virus coincided with a strict adherence to certain highly risky religious practices (such as communion from the same spoon), while the Georgian government’s stance in defense of pub

Adaptation to new ecological niches is known to spur population diversification and may lead to speciation if gene flow is ceased. While adaptation to the same ecological niche is expected to be parallel, it is more difficult to predict whether selection against maladaptive hybridization in secondary sympatry results in parallel divergence also in traits that are not directly related to the ecolog

Climbing fibers, which originate in the inferior olive and project to Purkinje cells and Golgi cells in the cerebellar cortex, were activated at low (0.4-Hz) and high (4-Hz) frequencies by peri-orbital stimulation in decerebrate ferrets. Climbing fiber responses were recorded as field potentials from the c3 zone of the cerebellar surface. When periorbital stimulation was applied at high frequency,

Background: In hereditary angioedema (HAE), low levels (type 1) or defect in function (type 2) of the serine-protease inhibitor C1 Inhibitor protein results in activation of the classical pathway of the complement system as well as the contact system. Here, we investigated the risk of comorbidities in HAE. Methods: Individuals with HAE (n = 239; identified through a physician made diagnosis) and a

Avhandlingens titel: ”Assessment of the right heart in pulmonary hypertension”Målet med avhandlingen var att undersöka de högersidiga hjärtrummens storlek ochfunktion hos patienter med förhöjt tryck i lungkretsloppet, pulmonell hypertension(PH). Detta utfördes i huvudsak med hjärtultraljud (ekokardiografi), men undersök -ningsmodaliteterna magnetkameraundersökning av hjärtat (MR) och högersidighjä

Since its origins in the 19th century, the SSE has instantiated a strong focus on the practice of solidarity alongside other political claims, thus supporting the idea that ‘another world is possible’, and economic transformation should accompany shifts in social relations (Laville and Salmon, 2014). However, despite its transformative poten-tial, solidarity has been the ‘silent S’ in the SSE, in