Introduction: Heterogeneity in cognitive outcomes and response to treatment has been described in Alzheimer’s disease (AD). Using the method of mixed models, higher resolution can be obtained to identify potential predictors of long-term outcomes. Aims: To analyse the impact of the APOE genotype, non-steroidal anti-inflammatory drug (NSAID) therapy and cholinesterase inhibitor treatment (ChEI) on

Comments as an expert and member of COST A5: Ageing and Technology Network, on a working paper for the European Commission

In this paper transient electromagnetic wave propagation in a stratified, anisotropic, dispersive medium is considered. Specifically, the direct scattering problem is addressed. The dispersive, anisotropic medium is modeled by constitutive relations (a 3 × 3 matrix-valued susceptibility operator)con taining time convolution integrals. In the general case, nine different susceptibility kernels char

A theory of viscoplasticity is formulated within a thermodynamic concept. The key point is the postulate of a dynamic yield surface, which allows us to take advantage of the postulate of maximum dissipation to derive an associated formulation of the evolutions laws for the internal variables without using penalty techniques that only hold in the limit it when viscoplasticity degenerates to invisci

This paper examines the impact of mutual inductance and parasitic capacitance on the phase-error performance for a class of CMOS quadrature voltage-controlled oscillators (QVCOs). Good agreement is found between theory, post-layout simulations, and measurement results. The QVCOs were implemented in a standard 0.35/spl mu/m CMOS process. All QVCOs display a center frequency of 2 GHz and a tuning ra

Majority of Malaysian motorcycle fatalities have occurred along straight road sections, which are mostly two-lane undivided roads with several small junctions or access points. In order to gain more insight into the actual road traffic situation and the course of events on these sites because, an observational and traffic conflict study, focusing on motorcyclists, was conducted by the author betwe

Regional cerebral blood flow (rCBF) was measured by the 133Xenon inhalation method in nine male chronic cannabis users. The rCBF level in cannabis users was significantly (11%) lower than that of age- and sex-matched healthy controls. Four of the subjects were reexamined after 9-60 days of detoxification and showed a significant (12%) increase of the CBF level at followup. No significant regional