Background and Aims: Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between fibre intake and the development of Crohn's disease [CD] and ulcerative colitis [UC] in a large European population. Methods: In total, 401 326 participants, aged 20-80 years, were recruited in eigh

The relationship between local labour market conditions and regional migration has been widely discussed within research. In Sweden, where interregional migration reached a peak in the 1960s but decreased substantially in the 1970s, the role of economic policy has been especially contended in light of the Swedish model and its official stress on regional mobility. By collecting and creating a new

Amyloid aggregates are associated with a range of human neurodegenerative disorders, and it has been shown that neurotoxicity is dependent on aggregate size. Combining molecular simulation with analytical theory, a predictive model is proposed for the adsorption of amyloid aggregates onto oppositely charged surfaces, where the interaction is governed by an interplay between electrostatic attractio

OBJECTIVE: To explore the treatment patterns of patients with a diagnosis related to chronic pain (DRCP) initiating pharmacological treatment indicated for neuropathic pain (NeuP: tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, and anticonvulsants).DESIGN: Retrospective study on administrative registers.SETTING: General population in Western Sweden (one sixth of the countr

The human host defense peptide, LL-37, is an important player in the first line of defense against invading microorganisms. LL-37 and its precursor, hCAP18, have been detected in unstimulated whole saliva but no reports showing hCAP18/LL-37 in isolated, parotid, and/or submandibular/sublingual saliva have been presented. Here, we measured the levels of hCAP18/LL-37 in human parotid and submandibul

Genomgång av filmer om Winston Churchill.

Utvecklingen inom gentekniken har gjort det möjligt att inom sjukvårdens ram undersöka många gener samtidigt genom helgenom-/helexomanalyser. Detta har hittills främst utnyttjats för diagnostik av personer, framför allt barn, med misstänkt ärftliga syndrom.Under de senaste tre åren har tekniken utnyttjats för att bygga upp plattformar att användas för kartläggning av recessiva sjukdomsanlag hos frDue to recent advances in molecular genetic testing, massive parallel sequencing has become possible at an affordable cost for health care. Thus, it is now possible to test healthy young persons for carriership of mutations in many genes for severe recessive genetic conditions – extended genetic carrier testing. The introduction of this test in Swedish health care must be accompanied by ethical co

Migration is energetically demanding and physiologically challenging. Migrating birds, for example, need to boost their antioxidant defenses to defeat the pro-oxidants produced during high energetic activity. The enhanced antioxidant defense possibly withdraws limited resources (e.g., energy or micronutrients) from other physiological functions, such as immune defense. Such a trade-off might not o

Study Objectives: Obesity is often associated with impaired sleep, whereas the impact of body mass index (BMI) at younger age and previous weight gain on sleep problems remains unknown. Methods: The present study utilized data from the Swedish EpiHealth cohort study. A total of 15845 participants (45–75 years) filled out an internet-based questionnaire. BMI was calculated from both measured data a

Lignin depolymerisation produces a large variety of low molecular weight phenolic compounds that can be upgraded to value-added chemicals. Detailed analysis of these complex depolymerisation mixtures is, however, hampered by the lack of resolving power of traditional analysis techniques. In this study, a novel online comprehensive two-dimensional reversed-phase liquid chromatography (RPLC) × super

The incidence of fragility fractures is expected to increase in the near future due to an aging population. Therefore, improved tools for fracture prediction are required to treat and prevent these injuries efficiently. For such tools to succeed, a better understanding of the deformation mechanisms in bone over different length scales is needed. In this study, an experimental setup including mecha

The excited state dynamics of solvated [Fe(bpy)(CN)4]2-, where bpy = 2,2′-bipyridine, show significant sensitivity to the solvent Lewis acidity. Using a combination of optical absorption and X-ray emission transient spectroscopies, we have previously shown that the metal to ligand charge transfer (MLCT) excited state of [Fe(bpy)(CN)4]2- has a 19 picosecond lifetime and no discernable contribution

The mechanism of the reaction of ketene with methyl radical has been studied by ab initio CCSD(T)-F12/cc-pVQZ-f12//B2PLYPD3/6-311G** calculations of the potential energy surface. Temperature- and pressure-dependent reaction rate constants have been computed using the Rice-Ramsperger-Kassel-Marcus (RRKM)-Master Equation and transition state theory methods. Three main channels have been shown to dom

IS strategic alignment remains a research phenomenon of key interest, specifically regarding the dimensions of social IS alignment (i.e., shared IS understanding among key organizational members) and intellectual IS alignment (i.e., IS/business strategy congruence). The examination of IS alignment has been predominantly limited to the examination of top ranks within the organization; however, we c

Phenomenological constitutive models of inelastic responses based on the methods of classical plasticity provide several advantages, especially in terms of computational efficiency. For this reason, they are attractive for the analysis of complex boundary value problems comprising large computational domains. However, for the analysis of problems dominated by single crystal behavior (e.g., inclusi

The structural investigation of cellular membranes requires access to model systems where the molecular complexity is representative of the cellular environment and that allow for the exploitation of structural techniques. Neutron scattering, and in particular neutron diffraction can provide unique and detailed information on the structure of lipid membranes. However, deuterated samples are desira

In this paper we present new techniques for constructing compact and robust minimal solvers for absolute pose estimation. We focus on the P4Pfr problem, but the methods we propose are applicable to a more general setting. Previous approaches to P4Pfr suffer from artificial degeneracies which come from their formulation and not the geometry of the original problem. In this paper we show how to avoi

In this paper we argue that the Wigner-Ville distribution (WVD), instead of the spectrogram, should be used as basic input into convolutional neural network (CNN) based classification schemes. The WVD has superior resolution and localization as compared to other time-frequency representations. We present a method where a large-size kernel may be learned from the data, to enhance features important

This article analyzes the effect of exporting activity on the innovative performances of firms in France, Germany, Italy, Spain, and UK. It argues that the positive effect of exporting on innovation usually found in the literature varies according to the specific destinations of exports, and it identifies two dimensions along which export destinations might differ: the level of foreign technologic