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Haematopoietic stem cells (HSCs) are important target cells for gene therapy of blood disorders due to their pluripotency and ability to reconstitute haematopoiesis following myeloablation and transplantation. HSCs can 'self-renew' and generate new stem cells. Genetically modified stem cells are therefore expected to last a lifetime in the recipient following blood and marrow transplantation, and
We propose and demonstrate a technique combining micro-photoluminescence imaging with scanning photolithography at Cryogenic temperatures for creating photoresist masks at designated locations relative to single selected self-assembled quantum dots. The technique is demonstrated by producing a photoresist mask on top of a single selected InP quantum dot imbedded in GaInP. A mesa containing the qua
We prove under quite general assumptions the global existence of classical solutions for elliptic equations with dynamic boundary conditions.
Purpose To evaluate retinal function and histopathology in rabbits treated orally with the antiepileptic drug topiramate. Methods Six rabbits were treated with a daily oral dose of topiramate during a period of eight months. Six rabbits receiving water served as controls. Blood samples were analyzed for determination of topiramate serum levels in order to ensure successful drug exposition. Standar
Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 i
Hepatitis B virus (HBV) replication is initiated by HBV RT binding to the highly conserved encapsidation signal, epsilon, at the 5' end of the RNA pregenome. Epsilon contains an apical stem-loop, whose residues are either totally conserved or show rare non-disruptive mutations. Here we present the structure of the apical stem-loop based on NOE, RDC and H-1 chemical shift NMR data. The H-1 chemical
Monte Carlo simulations and density functional calculations have been performed for charged macromolecules confined to planar slits. The force between the confining walls has been evaluated as a function of separation, while keeping the chemical potential of the macromolecules constant. Highly charged spherical particles and flexible polyelectrolyte chains in confinement give rise to depletion and
Human actions towards land, freshwater and oceans have already caused biodiversity to decline. This study aims to investigate attitudes towards the conservation of biological biodiversity among different groups in a Swedish city, Kristianstad. An inquiry including statements measuring attitudes towards the conservation of habitats, animals and plants, to the biological diversity within selected lo
OBJECTIVE: The aim of this study was to delineate the use of hormone replacement therapy (HRT) among women who were born between December 2, 1935, and December 1, 1945, and living in the Lund area of southern Sweden and to analyze factors that contribute to the acceptance and continuation of HRT. METHODS: All women received a generic questionnaire pertaining to demographic background, lifestyle, h
We consider the minimum line covering problem: given a set S of n points in the plane, we want to find the smallest number l of straight lines needed to cover all n points in S. We show that this problem can be solved in O(n log l) time if l is an element of O(log(1-is an element of) n), and that this is optimal in the algebraic computation tree model (we show that the Omega(n log l) lower bound h
We assess relative time courses of motor development in ferrets and rats and evaluate ferrets as experimental animals for studies of motor development. Motor behaviour of ferret pups was characterized in daily sessions from postnatal day (P) 2 to P63. Observations concerning rotational locomotion ('pivoting'), crawling, walking, upright standing ('rearing') and walking on a narrow path; righting o
Mediatorless (direct) electron transfer between bare and thiol-modified gold electrodes and fungal laccases from different sources has been demonstrated. The electrochemical activity of the enzymes from basidiomycetes Trametes hirstita. Trametes ochracea, and Cerrena maxima under aerobic and anaerobic conditions can clearly be observed using cyclic voltammetry and spectroelectrochemistry. Bioelect
The microbial mineralization of phenol and three chlorinated phenols (3,4-dichlorophenol, 2,4,5-trichlorophenol and pentachlorophenol) in the water column of 23 pristine, oligotrophic lakes of different humic content was investigated. During short-term (approximately 2 d) in situ incubations of water samples amended with C-14-labeled phenolic compounds, the fraction of the added pollutant minerali
A dolerite sill cutting slightly older basalt in west-central Sweden shows a strong chemical variation (54%
Currently there are over 1,000,000 human expressed sequence tag (EST) sequences available on the public database, representing perhaps 50-90% of all human genes. The cDNA microarray technique is a recently developed tool that exploits this wealth of information for the analysis of gene expression. In this method, DNA probes representing cDNA clones are arrayed onto a glass slide and interrogated w
