Importance: Blood-based tests for brain amyloid-β (Aβ) pathology are needed for widespread implementation of Alzheimer disease (AD) biomarkers in clinical care and to facilitate patient screening and monitoring of treatment responses in clinical trials. Objective: To compare the performance of plasma Aβ42/40 measured using 8 different Aβ assays when detecting abnormal brain Aβ status in patients w

Marine deposits of earliest Eocene age in northern Jutland, Denmark, are renowned for yielding diverse teleost assemblages that have proved central for enhancing our understanding of the early evolution of many extant actinopterygian clades. In this study, we investigate diminutive larval fish fossils from the Stolleklint Clay, Ølst Formation, that retain multiple soft-tissue features preserved as

The supply of carbon (C) from tree photosynthesis to ectomycorrhizal (ECM) fungi is known to decrease with increasing plant nitrogen (N) supply, but how this affects fungal nutrition and growth remains to be clarified. We placed mesh-bags with quartz sand, with or without an organic N (15N-, 13C-labeled) source, in the soil along a natural N supply gradient in boreal forest, to measure growth and

On March 11, 2020, the World Health Organization declared the emerging COVID-19 threat a pandemic following the global spread of the virus. A year later, a number of governments are being handed the concluding reports of national public inquiries tasked with investigating responses, mishaps, and identifying lessons for the future. The present article aims to identify a set of learning obstacles th

Wireless-based activity sensing has gained significant attention due to its wide range of applications. We investigate radio-based multi-class classification of human activities using massive multiple-input multiple-output (MIMO) channel measurements in line-of-sight and non line-of-sight scenarios. We propose a tensor decomposition-based algorithm to extract features by exploiting the complex cor

Purpose: To analyse and compare the number and interval of anti-vascular endothelial growth factor (anti-VEGF) injections in neovascular age-related macular degeneration (nAMD), as well as the visual development in patients followed up for one to three years in clinical practice and during different index periods. Methods: This observational study included treatment-naïve eyes with nAMD from the S

Aim: We investigated the timing of survival differences and effects on morbidity for foetuses alive at maternal admission to hospital delivered at 22 to 26 weeks’ gestational age (GA). Methods: Data from the EXPRESS (Sweden, 2004–07), EPICure-2 (England, 2006) and EPIPAGE-2 (France, 2011) cohorts were harmonised. Survival, stratified by GA, was analysed to 112 days using Kaplan-Meier analyses and

The efficiency of bulk heterojunction (BHJ) based organic solar cells is highly dependent on the morphology of the blend film, which is a result of a fine interplay between donor, acceptor, and solvent during the film drying. In this work, a versatile set-up of in situ spectroscopies is used to follow the morphology evolution during blade coating of three iconic BHJ systems, including polymer:full

Political scientists routinely face the challenge of assessing the quality (validity and reliability) of measures in order to use them in substantive research. While stand-alone assessment tools exist, researchers rarely combine them comprehensively. Further, while a large literature informs data producers, data consumers lack guidance on how to assess existing measures for use in substantive rese

There is concern that immunotoxic environmental contaminants, particularly perfluoroalkyl substances (PFAS), may play a role in the clinical course of COVID-19 and epidemiologic studies are needed to answer if high-exposed populations are especially vulnerable in light of the ongoing pandemic. The objective was, therefore, to determine if exposure to highly PFAS-contaminated drinking water was ass

The obligate pollination mutualism between Yucca and yucca moths is a classical example of coevolution. Oviposition and active pollination by female yucca moths occur at night when Yucca flowers are open and strongly scented. Thus, floral volatiles have been suggested as key sensory signals attracting yucca moths to their host plants, but no bioactive compounds have yet been identified. In this st

Index tracking and hedge fund replication aim at cloning the return time series properties of a given benchmark, by either using only a subset of its original constituents or by a set of risk factors. In this paper, we propose a model that relies on the Sorted (Formula presented.) Penalized Estimator, called SLOPE, for index tracking and hedge fund replication. We show that SLOPE is capable of not

The purpose of this article is to evaluate the impact of university ecosystems on entrepreneurial intention and self-efficacy of Brazilian undergraduate students. The empirical exercise relies on Structural Equations Modelling based on data of 468 students from 70 universities across the country. Results indicate that traditional approaches to foment entrepreneurship are less effective than nurtur

Leveraging the biocatalytic machinery of living organisms for fabricating functional bioelectronic interfaces, in vivo, defines a new class of micro-biohybrids enabling the seamless integration of technology with living biological systems. Previously, we have demonstrated the in vivo polymerization of conjugated oligomers forming conductors within the structures of plants.Here, we expand this conc

Morphometric relationships between populations of Papaver radicatum within the southern Norwegian mountains were investigated using canonical variates analysis and Ward's clustering on capsule and leaf character sets. The survey describes patterns of variation among 13 wild-scored populations from five geographically disjunct localities, usually assigned to five races or subspecies. Our results fr

There is a geographic separation of the 2 pollen morphs in European Silene latifolia, with the changeover zone running NW-SE from the Netherlands to Greece. Reticulate grains are characteristic of western populations, microechinate grains of eastern populations. -from AuthorsDept of Population & Evol Biol, Univ of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands.

Silene diclinis is a dioecious perennial herb, restricted to a small area of the SE Spanish province of Valencia. Polyacrylamide gel electrophoresis and morphometric analysis were carried out on cultivated material derived from seed collected from the main population of S. diclinis at Játiva. Only two out of 26 inferred enzyme loci showed substantial variation. There was some indication of populat

Morphological and biochemical data were analysed from 30 greenhouse-grown populations of European Silene latifolia. Six separate character sets (flavones, seed, pollen, capsules, male and female flower morphology) were used in the analyses. There was broad-scale congruence between trends of geographic variation in most character sets, with the populations being assigned to western (or southern and