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INTRODUCTION: Plasma biomarkers’ utility for predicting incident mild cognitive impairment (MCI) remains unclear. We evaluated associations of plasma Alzheimer's disease (AD) biomarkers and amyloid positron emission tomography (PET) with transitions from cognitively unimpaired (CU) to MCI in the Mayo Clinic Study of Aging (MCSA) and BioFINDER-2 studies. METHODS: Associations of continuous baseline

The antioxidant α1-microglobulin (A1M) has been suggested as kidney protector during 177Lu-octreotate treatment. The aim of this work was to evaluate apoptotic-related transcript expression in kidney cortex and medulla following injection of 177Lu-octreotate and/or A1M. Mice were injected with 177Lu-octreotate, A1M, or 177Lu-octreotate + A1M. Control groups received PBS or vehicle solution. Animal

Background: Deep learning (DL)-based organ segmentation is increasingly used in radiotherapy. While methods exist to generate voxel-wise uncertainty maps from DL-based auto-segmentation models, these maps are rarely presented to clinicians. Purpose: This study aimed to evaluate the impact of DL-generated uncertainty maps on experienced radiation oncologists during the manual correction of DL-based

Label-free chemical and structural imaging of complex living tissue and biological systems is the holy grail of biomedical research and clinical diagnostics. The current analysis techniques are time-consuming and/or require extensive sample preparation, often due to the presence of interfering molecules such as water, making them unsuitable for the analysis of such systems. Here, we demonstrate a

Label-free chemical imaging of living and functioning systems is the holy grail of biochemical research. However, existing techniques often require extensive sample preparation to remove interfering molecules such as water, rendering many molecular imaging techniques unsuitable for in situ structural studies. Here, we examined freshly extracted tissue biopsies and living small vertebrates at submi

The identification of jets originating from quarks and gluons, often referred to as quark/gluon tagging, plays an important role in various analyses performed at the Large Hadron Collider, as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced background. This paper describes the measurement of the efficiencies of quark/gluo

The Nordic Society for Radiation Protection (NSFS) was founded in 1964 at the initiative of Rolf Sievert. Its task is to activate the exchange of knowledge and experience in the Nordic countries regarding protection against ionizing and non-ionizing radiation, for all kinds of occupational, medical, or public exposures. NSFS has always included members from all five Nordic countries and was a foun

This paper presents a search for a new Z′ resonance decaying into a pair of dark quarks which hadronise into dark hadrons before promptly decaying back as Standard Model particles. This analysis is based on proton-proton collision data recorded at s = 13 TeV with the ATLAS detector at the Large Hadron Collider between 2015 and 2018, corresponding to an integrated luminosity of 139 fb−1. After sele

In modern society with its ever-increasing interconnectedness and digitalisation, cybersecurity becomes a prominent issue with tangible ramifications beyond the cyber space. To effectively counter attacks, organisations and their cybersecurity managers must anticipate potential adverse events. Most public research in cybersecurity is concentrated on technology; however, some literature suggests t

Context Although prototyping is widely utilized in product and user interface design, as well as in requirements engineering practices within agile development, there exists a lack of theoretical frameworks surrounding this methodology. Aims The primary objective of this study is to explore both the benefits and costs of employing different types of prototyping with different levels of complexity

Byggnader är en central komponent i 3D stadsmodeller. Att skapa sådana modeller enligt relevant standard är inte alltid enkelt och kan vara tidskrävande. Den här studien undersöker en metod att skapa byggnadsmodeller utifrån the svenska nationella specifikationen (NS) för byggnader, i en detaljnivå (LOD) som inkluderar takform. Metoden utvärderar hur byggnadsytor (registerbyggnad) tillsammans med Buildings are a central component of three-dimensional (3D) city models. Generating such models according to an appropriate standard is not always straightforward and can be time-consuming. This study explores a method for generating building models that comply with the Swedish national specification (NS) for buildings, at a level of detail (LOD) that includes roof structures. The method evaluates

Vad kan vi lära oss om gränser och migrationspolitik när vi betraktar dem ur perspektivet hos de samhällen som lever i gränsområdena – och genom mobilitetens teoretiska linser?Denna avhandling undersöker effekterna av EU's politik för gränsexternalisering på dem som påverkas mest av den, med fokus på de levda erfarenheterna hos senegalesiska samhällen runtom i Senegal. Genom omfattande etnografiskWhat do we learn about borders and migration policies when we examine them from the perspective of communities living in the borderlands, and through the theoretical lenses of mobility? This thesis explores the effects of EU border externalisation policies on those most affected by them, focusing on the lived experiences of Senegalese communities throughout Senegal. Through extensive ethnographic

We present a novel method for in-line acoustofluidic separation of cancer cells directly from whole blood. We report for the first time the observation that blood cells can self-organize when packed closely together in an acoustic field. We utilize this effect to enrich K-562 cancer cells and white blood cell subpopulations from whole blood at normal hematocrit levels. Further, we investigate the

The Indian leopard is a species that frequently comes into conflict with humans due to their adaptability and wide habitat range, allowing them to persist around urban landscapes like Bengaluru. While the surrounding landscape naturally supports leopards, human factors have driven them to frequent urban areas. Increased leopard sightings have led to more translocations, but relocating animals base

Age-Friendly Cities and Communities (AFCC) is a key global WHO initiative aimed at fostering environments that promote healthy aging for everyone. As AFCC initiatives continue to expand, there is an increasing need to enhance monitoring and evaluation systems to effectively assess their progress and impact. However, significant knowledge gaps persist, particularly in the development of evaluation

Apolipoprotein E4 (ApoE4), the major genetic risk factor for Alzheimer's disease (AD), is vital for understanding cellular processes involved in AD pathogenesis. Evidence implicates endosomes as a central player in AD, where endosomal enlargement in neurons is among the earliest changes in AD. This enlargement was reported to be enhanced in APOE4 carriers. Cells internalize ApoE into endosomes for

MicroRNAs (miRNAs) are pivotal post-transcriptional regulators that orchestrate gene expression programs governing cancer initiation, progression, metastasis, and therapeutic resistance. Among their many targets, the WNT signaling pathway, a key driver of malignancy, is tightly controlled by miRNAs, forming intricate feedback loops that shape tumor behavior. Concurrently, flavonoids, naturally occ

Staphylococcus aureus remains one of the most elusive targets in bacterial vaccinology, primarily due to its complex immune evasion strategies and the phenomenon of immune imprinting. Despite decades of research and numerous clinical trials, no vaccine has demonstrated protective efficacy in humans. This review examines the underlying reasons for these failures and proposes a rational, integrativ

Gastrointestinal (GI) cancers, including esophageal, gastric, pancreatic, liver, and colorectal malignancies, represent a major global health burden due to their high incidence, aggressive nature, and limited treatment outcomes. This review explores the therapeutic potential of carvacrol, a naturally occurring monoterpenoid phenol predominantly found in oregano and other aromatic plants. Carvacrol

Industrial CO2 emissions, particularly from flue gases, are a major barrier to climate change mitigation. Carbon capture, particularly with bioenergy (BECCS), offers a pathway to negative emissions. This study models an MEA-based carbon capture system using operational data from a stand-alone pulp mill, focusing on its energy impact and optimization strategies. The analysis distinguishes between h