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Editorial: Coping With Environmental Fluctuations : Ecological and Evolutionary Perspectives
Numerical simulation of a mixed-mode reaction front in a PPC engine
The ignition process, mode of combustion and reaction front propagation in a partially premixed combustion (PPC) engine running with a primary reference fuel (87 vol% iso-octane, 13 vol% n-heptane) were investigated numerically in a large eddy simulation (LES). A one-equation sub-grid scale model coupled to the partially stirred reactor model and a finite rate chemical model were used in LES. Diff
Genremönster i Ministern har ordet : Regeringar rapporterar om bolag med statligt ägande
The article deals with the genre consolidated government accounts of state-owned enterprises in Finland and Sweden. More specifically, the study is focused on the subgenre the foreword of the responsible minister, which we label Statement from the Minister in analogy with Statement from the CEO in the related genre corporate annual reports. The primary data consist of Statement from the Minister iThe article deals with the genre consolidated government accounts of state-owned enter-prises in Finland and Sweden. More specifically, the study is focused on the subgenre the foreword of the responsible minister, which we label Statement from the Minister in anal-ogy with Statement from the CEO in the related genre corporate annual reports. The pri-mary data consist of Statement from the Ministe
A Ca. 2.25 Ga mafic dyke swarm discovered in the Bastar craton, Central India : Implications for a widespread plume-generated large Igneous Province (LIP) in the Indian shield
A precise U–Pb baddeleyite age (2251 ± 4 Ma) has been obtained for an ENE-trending dyke exposed near the Chhura region of the Bastar craton, and additional dykes of similar trend are also reported from other parts of the northern Bastar craton such as in the Dongergarh and Pakhanjore areas. We propose a new widespread ENE-trending ca. 2.25 Ga Chhura mafic dyke swarm in the Bastar craton, which rep
Identification of a new 485 Ma post-orogenic mafic dyke swarm east of the Pan-African Saldania-Gariep Belt of South Africa
Western South Africa between Cape Town and the Namibian border hosts many dyke swarms that strike broadly to the NW and NNW, towards the reconstructed plume-centre of the c. 130 Ma Parana-Etendeka Large Igneous Province (LIP) but are undated. U-Pb ID-TIMS age determinations on baddeleyite from two NNW-striking dykes (~100 km long) parallel to the Namaqualand coast yield 487 ± 8 Ma and 482 ± 7 Ma a
Lifetime measurements of excited states in 169,171,173Os : Persistence of anomalous B(E2) ratios in transitional rare earth nuclei in the presence of a decoupled i13/2 valence neutron
Lifetimes of low-lying excited states in the νi13/2+ bands of the neutron-deficient osmium isotopes 169,171,173Os have been measured for the first time using the recoil-distance Doppler shift and recoil-isomer tagging techniques. An unusually low value is observed for the ratio B(E2;21/2+→17/2+)/B(E2;17/2+→13/2+) in 169Os, similar to the “anomalously” low values of the ratio B(E2;41+→21+)/B(E2;21+
Merosin deficient congenital muscular dystrophy type 1A : An international workshop on the road to therapy 15-17 November 2019, Maastricht, the Netherlands
Differential trajectories of hypometabolism across cognitively-defined Alzheimer's disease subgroups
Disentangling biologically distinct subgroups of Alzheimer's disease (AD) may facilitate a deeper understanding of the neurobiology underlying clinical heterogeneity. We employed longitudinal [18F]FDG-PET standardized uptake value ratios (SUVRs) to map hypometabolism across cognitively-defined AD subgroups. Participants were 384 amyloid-positive individuals with an AD dementia diagnosis from ADNI
On the generalizability of diffusion MRI signal representations across acquisition parameters, sequences and tissue types : Chronicles of the MEMENTO challenge
Diffusion MRI (dMRI) has become an invaluable tool to assess the microstructural organization of brain tissue. Depending on the specific acquisition settings, the dMRI signal encodes specific properties of the underlying diffusion process. In the last two decades, several signal representations have been proposed to fit the dMRI signal and decode such properties. Most methods, however, are tested
Age-related differences in network structure and dynamic synchrony of cognitive control
Cognitive trajectories vary greatly across older individuals, and the neural mechanisms underlying these differences remain poorly understood. Here, we investigate the cognitive variability in older adults by linking the influence of white matter microstructure on the task-related organization of fast and effective communications between brain regions. Using diffusion tensor imaging and electroenc
Brain tissues have single-voxel signatures in multi-spectral MRI
Since the seminal works by Brodmann and contemporaries, it is well-known that different brain regions exhibit unique cytoarchitectonic and myeloarchitectonic features. Transferring the approach of classifying brain tissues – and other tissues – based on their intrinsic features to the realm of magnetic resonance (MR) is a longstanding endeavor. In the 1990s, atlas-based segmentation replaced earli
En bra lektion är rätt mycket jazz : Villkor och förutsättningar för ämneslärarstudenters lärande av praktiska yrkeskunskaper i verksamhetsförlagd utbildning
Lärares praktiska yrkeskunskaper bjuder motstånd mot förspråkligande. Detta problem föreligger inte minst i lärarutbildningen, där det i verksamhetsförlagda delar kan råda både osäkerhet och skilda uppfattningar om vad studenterna behöver göra eller prestera för att uppnå de mål som (bokstavligen) föreskrivits dem. Syftet med avhandlingen har varit att beskriva och förstå villkor och förutsättningTeachers' practical professional skills offer resistance to advocacy. This problem exists not least in teacher education, where in work-based parts there can be both uncertainty and different perceptions of what the students need to do or perform in order to achieve the goals that are (literally) prescribed for them. The purpose of the dissertation has been to describe and understand conditions an
Registered nurses and undergraduate nursing students' attitudes to performing end-of-life care
Registered Nurses (RNs) are in the immediate position to provide End-of-life (EOL) care and counselling for patients and families in various settings. However, EOL-care often creates feelings of uncertainty and inadequacy linked to inexperience, lack of education, and attitude. To identify and describe factors associated with RNs' attitudes towards EOL-care, and to identify whether and how these a
DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease
Background: α-synuclein (α-syn) aggregation can lead to degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) as invariably observed in patients with Parkinson's Disease (PD). The co-chaperone DNAJB6 has previously been found to be expressed at higher levels in PD patients than in control subjects and was also found in Lewy bodies. Our previous experiments showed that k
New developments in virtual reality-assisted treatment of aggression in forensic settings: The case of VRAPT
Aggression is a known problem in individuals being cared for in forensic settings, yet the evidence base for its treatment is scarce. Virtual Reality (VR) has been proposed as a promising addition to interventions in forensic settings, as it may increase the motivation among participants, bridge the gap between real life, therapeutic and laboratory experiences, and increase the ecological validity
Cross-reactivity of antibody responses to Borrelia afzelii OspC : Asymmetry and host heterogeneity
The tick-transmitted bacterium Borrelia afzelii consists of a number of antigenically different strains — often defined by outer surface protein C (OspC) genotype — that coexist at stable frequencies in host populations. To investigate how host antibody responses affect strain coexistence, we measured antibody cross-reactivity to three different OspC types (OspC 2, 3 and 9) in three different stra
Deep learning reconstruction of digital breast tomosynthesis images for accurate breast density and patient-specific radiation dose estimation
The two-dimensional nature of mammography makes estimation of the overall breast density challenging, and estimation of the true patient-specific radiation dose impossible. Digital breast tomosynthesis (DBT), a pseudo-3D technique, is now commonly used in breast cancer screening and diagnostics. Still, the severely limited 3rd dimension information in DBT has not been used, until now, to estimate
Longitudinal vibration interferes with cross-bridge attachment and prevents muscle fibre shrinkage under PSE-like conditions
The impact of longitudinal vibration on cross-bridge attachments between myofilaments was investigated in single fibres and intact muscle. Sinusoidal length vibration (frequency 50 Hz, amplitude 5% of fibre length) reduced active force by 40% when fibres were activated by elevation of [Ca2+], but did not alter the force when fibres were in rigor state. When vibrated for 30 min in rigor at pH 5.5 a
Decadal-scale subaerial beach and dune evolution at Duck, North Carolina
Thirty-nine years of high-resolution data from 1981 to 2019 surveyed by the Field Research Facility (FRF) of the US Army Corps of Engineers at Duck, North Carolina, in the United States, were analyzed for temporal and spatial characteristics of beach morphology evolution employing a range of statistical methods. In the study, emphasis was put on the response of the subaerial part of the beach prof