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BACKGROUND: Relationship between genetic factors and pathological features of Alzheimer's disease (AD) may be studied with biomarker, using both polygenic risk scores (PRSs), as well as individual genetic variants in genome-wide association studies (GWAS). METHOD: In the Swedish BioFINDER study, we used a priori PRS for AD based on findings in recent GWAS, and AD related biomarkers in cerebrospina

The transverse momentum (pT) differential yields of (anti-)He3 and (anti-)H3 measured in p-Pb collisions at sNN = 5.02 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The ratios of the pT-integrated yields of (anti-)He3 and (anti-)H3 to the proton yields are reported, as well as the pT dependence of the coalescence parameters B3 for (anti-)He3 and (anti-)H3. For (anti-)He3, the re

Jet substructure quantities are measured using jets groomed with the soft-drop grooming procedure in dijet events from 32.9 fb-1 of pp collisions collected with the ATLAS detector at s=13 TeV. These observables are sensitive to a wide range of QCD phenomena. Some observables, such as the jet mass and opening angle between the two subjets which pass the soft-drop condition, can be described by a hi

Joacim Rocklövs angrepp på rapporten som jag och två medarbetare har publicerat som visar att nedstängningarna inte har haft nämnvärd effekt på dödligheten i corona, är okunnigt, alldeles för snävt och missvisande, skriver Lars Jonung, professor emeritus i nationalekonomi.

This paper describes a strategy for a general search used by the ATLAS Collaboration to find potential indications of new physics. Events are classified according to their final state into many event classes. For each event class an automated search algorithm tests whether the data are compatible with the Monte Carlo simulated expectation in several distributions sensitive to the effects of new ph

Syftet med hemsidan är att presentera vetenskapliga artiklar inom miljö- och hållbarhetsforskning genom ett samspel mellan musik och text. Vi hoppas på detta sätt att kunna tillgängliggöra dessa fakta och frågeställningar för en bredare publik. På ett okonventionellt och nyskapande vis, genom att kombinera musik och illustrationer/recitation, vill vi föra ut budskapet om, och öka intresset för, hu

Objectives: Rituximab (RTX) is an anti-CD20 antibody that selectively depletes B cells and has emerged as a therapy for ANCA-associated vasculitis (AAV) during the past decade. This study sought to quantify and determine potential risk factors for severe infections in AAV patients treated with RTX at rheumatology clinics in Mexico City, Mexico and Lund, Sweden. Methods: The study consisted of a re

This chapter explores how diffent approaches to the concept of legitimacy are reflected in the different understandings of law endorsed by legal positivism, legal idealism and legal realism.

Frontotemporal dementia type 3 (FTD3), caused by a point mutation in the charged multivesicular body protein 2B (CHMP2B), affects mitochondrial ultrastructure and the endolysosomal pathway in neurons. To dissect the astrocyte-specific impact of mutant CHMP2B expression, we generated astrocytes from human induced pluripotent stem cells (hiPSCs) and confirmed our findings in CHMP2B mutant mice. Our

A search is performed for a long-lived particle decaying into a final state that includes a pair of muons of opposite-sign electric charge, using proton-proton collision data collected at s=13 TeV by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 32.9 fb-1. No significant excess over the Standard Model expectation is observed. Limits at 95% confidence

BACKGROUND: In patients with AD, CSF Aβ42 is reduced while Aβ40 remains unchanged. It has been suggested that altered CSF Aβ42 is due to aggregation of this peptide into insoluble plaques, resulting in less soluble Aβ42 available for secretion to the CSF. However, the relations between soluble and insoluble Aβ42 and Aβ40 in the brain and the concentrations of these Aβ peptides in CSF are not well

A search for heavy neutral Higgs bosons is performed using the LHC Run 2 data, corresponding to an integrated luminosity of 139 fb-1 of proton-proton collisions at s=13 TeV recorded with the ATLAS detector. The search for heavy resonances is performed over the mass range 0.2-2.5 TeV for the τ+τ-decay with at least one τ-lepton decaying into final states with hadrons. The data are in good agreement

A search for heavy neutral Higgs bosons produced in association with one or two b-quarks and decaying to b-quark pairs is presented using 27.8 fb-1 of s=13 TeV proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider during 2015 and 2016. No evidence of a signal is found. Upper limits on the heavy neutral Higgs boson production cross section times its branching rati

BACKGROUND: Prior to COVID-19, >90% of caregivers of people with brain health challenges (dementia, mental ill health, intellectual disability) experienced high levels of distress, burden, loneliness and social isolation. The COVID-19 pandemic has significantly increased these impacts, particularly since these caregivers are often older and physically vulnerable themselves. The aim of this cross-s

BACKGROUND: To examine associations between the APOE-ε2 and APOE-ε4 alleles and core Alzheimer's disease (AD) pathological hallmarks as measured by amyloid-β (Aβ) and tau PET in older individuals without dementia. METHOD: We analyzed data from 462 ADNI participants without dementia who underwent Aβ ([18 F]florbetapir or [18 F]florbetaben) and tau ([18 F]flortaucipir) PET, structural MRI and cognit

The inclusive top quark pair (tt¯) production cross-section σtt¯ has been measured in proton–proton collisions at s=13TeV, using 36.1 fb- 1 of data collected in 2015–2016 by the ATLAS experiment at the LHC. Using events with an opposite-charge eμ pair and b-tagged jets, the cross-section is measured to be: σtt¯=826.4±3.6(stat)±11.5(syst)±15.7(lumi)±1.9(beam)pb,where the uncertainties reflect the l

COVID-19 is characterized by a dysregulated and excessive inflammatory response and, in severe cases, acute respiratory distress syndrome. We have recently demonstrated a previously unknown high-affinity interaction between the SARS-CoV-2 spike (S) protein and bacterial lipopolysaccharide (LPS), leading to the boosting of inflammation. Here we present a mouse inflammation model employing the coadm

The inclusive J/ψ meson production in Pb–Pb collisions at a center-of-mass energy per nucleon–nucleon collision of sNN=5.02 TeV at midrapidity (|y|<0.9) is reported by the ALICE Collaboration. The measurements are performed in the dielectron decay channel, as a function of event centrality and J/ψ transverse momentum pT, down to pT=0. The J/ψ mean transverse momentum 〈pT〉 and rAA ratio, defined as

The Swedish gender-inclusive pronoun hen can be used generically (referring to anyone), or specifically (referring to non-binary gender identities). Three studies tested evaluations and use of hen, and individual-level predictors. In Study 1 (N = 2145), specific hen was slightly favoured over generic hen. In Study 2 (N = 297), hen was more negatively evaluated than binary pronouns, and generic hen