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Aims: Embryonal tumours with PLAGL1 or PLAGL2 amplification (ET, PLAGL) show substantial heterogeneity regarding their clinical characteristics and have been treated inconsistently, resulting in diverse outcomes. In this study, we aimed to evaluate the clinical behaviour of ET, PLAGL and elucidate their response pattern across the different applied treatment regimens. Methods: We conducted an in-d

Following the recent resurgence of capitalism as a key subject in historical analysis, historians have highlighted the globally interconnected making and remaking of capitalism. Commodity-centred histories in global history have shown how to write locally grounded histories of global capitalism emphasising the complex and contingent relationship between the local and the global. In these accounts,

Superconductor-semiconductor hybrid systems play a crucial role in realizing nanoscale quantum devices, including hybrid qubits, Majorana bound states, and Kitaev chains. For such hybrid devices, subgap states play a prominent role in their operation. In this paper, we study these subgap states via Coulomb and tunneling spectroscopy through a superconducting island defined in a semiconductor nanow

Objective: For better management of RA, new biomarkers are needed to predict the development of different disease courses. This study aims to identify autoantibodies against epitopes on proteins in the joints and to predict disease outcome in patients with new onset RA. Methods: Sera from new-onset RA patients from the Swedish BARFOT (Better Anti Rheumatic PharmacOTherapy) and TIRA-2 (Swedish acro

Naturvetenskap, teknik, ingenjörsvetenskap och matematik, på engelska ofta grupperade under akronymen STEM, är traditionellt mansdominerade områden. Särskilt inom ingenjörsvetenskap och teknologi är kvinnor fortfarande kraftigt underrepresenterade. Bristen på kvinnor inom STEM innebär utmaningar i att möta arbetsmarknadens behov, för produktkvalitet på grund av brist på olika perspektiv i designprScience, technology, engineering and mathematics, often grouped under the acronym STEM, are traditionally male dominated fields. Especially in engineering and technology, women continue to be heavily underrepresented. The lack of women in STEM poses challenges for meeting the labor market demands, for product quality due to a lack of diverse perspectives in the design process, and for gender equal

Importance: Cutaneous malignant neoplasms are the most common subsequent neoplasm after blood or marrow transplant (BMT), but a full assessment among survivors is lacking. Objective: To identify risk factors for subsequent cutaneous malignant neoplasms using the BMT Survivor Study (BMTSS). Design, Setting, and Participants: This retrospective cohort study included patients who underwent transplant

Green growth attempts to achieve sustainable development under continued economic growth and is currently one of the leading policy responses to mitigate climate change and prevent environmental collapse. We surveyed 3,028 academics in 101 countries on its feasibility and found strong divergence in endorsement, with 59% endorsing green growth. We identify various factors associated with beliefs ab

We show that bipartite bound entangled states make possible violations of correlation inequalities in the prepare-and-measure scenario. These inequalities are satisfied by all classical models as well as by all quantum models that do not feature entanglement. In contrast to the known Bell inequality violations from bound entangled states, we find that the violations in the prepare-and-measure scen

The Wide Field Camera 3 (WFC3) instrument on the Hubble Space Telescope has provided an abundance of exoplanet spectra over the years. These spectra have enabled analysis studies using atmospheric retrievals to constrain the properties of these objects. However, follow-up observations from the JWST have called into question some of the results from these older datasets, and highlighted the need to

The statistics of transmitted photons in microwave cavities play a foundational role in microwave quantum optics and its technological applications. By utilizing quantum mechanical phase-space methods, we here develop a general theory of the photon counting statistics in Gaussian bosonic networks consisting of driven cavities with beamsplitter interactions and two-mode-squeezing. The dynamics of t

Background: Branched-chain amino acids (BCAAs, isoleucine, leucine, and valine) are commonly applied to promote muscle protein synthesis. However, the effects of BCAAs on exercise-induced substrate metabolism, performance and post-exercise fatigue during endurance exercise remain unclear. Methods: In a double-blind cross-over design, eleven active males completed 1 h of constant load exercise (CLE

Background: Parkinson’s disease (PD) is a neurodegenerative disorder associated with substantial costs that escalate as the disease progresses. Previous research has explored the relationship between disease progression, motor symptoms, and the economic burden of PD. However, there is a lack of studies focusing on the relationship between costs and non-motor symptoms (NMS). Objective: To examine t

Monolayer molybdenum ditelluride (MoTe2) attracted intensive scientific interest due to the small energy difference between its semiconducting (1H) and semimetallic (1T’) phases. Understanding MoTe2 polymorphism phenomena and developing pathways to induce reversible phase transformations is of great scientific and practical importance to develop semiconductor-semimetal phase change devices. In thi

How actors relate to the future has long been considered important in research on the governance of transformations towards sustainability. Recent contributions have explored the politics at play in the ‘making’ of futures and the forming of collective expectations. Building on the concept of socio-material incumbency and integrating academic discussions which appreciate the politics of future-mak

The German transportation sector's negative contribution to climate change amongst broader social, environmental, and economic problems is applying evermore pressure to the prevailing automobility regime to bring about its transformation. However, the vision of this transition, referred to as the Verkehrswende or Mobilitätswende, is highly contested, with varying conceptions of different actors ab

Objective: To evaluate hand and arm function and its association with motor symptoms as well as activities of daily living (ADL) in de novo Parkinson’s disease (PD).Background: Motor symptoms and disability in upper limb are common in PD and usually assessed using Unified PD Rating Scale (UPDRS). Activities, like reaching, grasping, manipulating objects, writing, dressing, and eating, may be more Objective: To evaluate hand and arm function and its association with motor symptoms as well as activities of daily living (ADL) in de novo Parkinson’s disease (PD).Background: Motor symptoms and disability in upper limb are common in PD and usually assessed using Unified PD Rating Scale (UPDRS). Activities, like reaching, grasping, manipulating objects, writing, dressing, and eating, may be more

The family Eulophidae is a highly diverse monophyletic taxon recognizable chiefly by reduction in features of the antennae and legs, including having at most ten flagellomeres and four tarsomeres, and a reduced protibial spur. Eulophidae exhibit a very wide diversity of host relationships. Some are phytophagous, but most are idiobiont or koinobiont parasitoids of arthropods and even nematodes. The

Microplastics (MPs) in biosolids used as soil amendments are of growing concern. The purpose of this study was to improve the characterization of MPs in complex biosolid matrices by optimizing sample preparation for morphological and chemical analyses with different spectroscopic techniques. We compared extraction procedures involving Fenton oxidation (F), Fenton plus sodium dodecyl sulfate (SDS),

High-dimensional systems are an important frontier for photonic quantum correlation experiments. These correlation tests commonly prescribe measurements with many possible outcomes but they are often implemented through many individual binary-outcome measurements that use only a single-detector. Here, we discuss how this binarization procedure for multioutcome measurements can open a loophole, unl