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Long bone defects can be managed by the induced membrane technique together with autologous bone graft. However, graft harvest is associated with donor site morbidity. This study investigates if a tricalcium phosphate hydroxyapatite scaffold can be used alone or in combination with bone active drugs to improve healing. Sprague Dawley rats (n = 40) were randomized into four groups. (A) scaffold, (B

In this study we establish the use of optical non-contact profilometry combined with low vacuum scanning electron microscopy (LV SEM) for the investigation of lipid surfaces. We illustrate, by using profilometry, a methodology for investigation of chocolate surface topology as a function of time, in the same area of interest. Both qualitative and quantitative data analysis has been performed for p

Aim: The aim of the study was to reveal young carers' views of design of a web-based support system (WBSS) directed to them and the differences between their views and the views of project representatives (PRs), in a participatory design process. Methods: Eight young people, 17-24 years, were involved in either a work or a test group. The work group participated in video-recorded design meetings w

A plethora of peptides are generated intracellularly, and most peptide-human leukocyte antigen (HLA)-I interactions are of a transient, unproductive nature. Without a quality control mechanism, the HLA-I system would be stressed by futile attempts to present peptides not sufficient for the stable peptide-HLA-I complex formation required for long term presentation. Tapasin is thought to be central

High-resolution neutron counting sensors with microchannel plates coupled to a Timepix readout enable high spatial (similar to 55 mu m) and temporal (similar to 1 mu s) accuracy for each detected thermal and cold neutron. One of the attractive applications for those sensors is the high-resolution strain mapping in engineering samples through transmission Bragg edge diffraction. The unique combinat

Physical activity and exercise is the mainstay of chronic disease prevention and health maintenance for all people with and without a disability, and clear evidence exists of the benefits among various populations with neurologic disabilities. However, the potential benefits of organized sports for people with neurologic disabilities are not as well explored. In this narrative review, current evid

To promote a healthy and active lifestyle there is a need to increase our knowledge of the level of physical activity (PA) among people with late effects of polio.

Integrated cross-sectoral impact assessments facilitate a comprehensive understanding of interdependencies and potential synergies, conflicts, and trade-offs between sectors under changing conditions. This paper presents a sensitivity analysis of a European integrated assessment model, the CLIMSAVE integrated assessment platform (IAP). The IAP incorporates important cross-sectoral linkages between

In initiating the development of a large-scale golf resort in Aberdeenshire, Trump International Golf Links Scotland made a relatively unknown site central to Scottish planning debates. A stretch of land along the North Sea coast north of Aberdeen became linked to new possible futures. Part of the site developed consisted of moving sand dunes given environmental protection as a Site of Special Sci

The zinc(II) coordination chemistry of the bioinspired bis(tetradentate) ligand 3,5-bis{bis[2-(1-methylimidazolyl)methyl]aminomethyl}pyrazole (L) was studied in detail both in solution and in the solid state. Six different species were determined in aqueous solution by means of potentiometry within the pH range 211, namely mononuclear [ZnH2L]4+, dinuclear [Zn2L]4+, [Zn2H1L]3+ and [Zn2H2L]2+, as we

Females often base their mate selection on multiple male traits. Different cues may be weighted differently in mating decisions, and play different roles such as indicating species identity or condition. The ontogeny of preferences for each cue can differ, which may offer a proximate explanation for the differential female evaluation of multimodal traits of males. We investigated whether female pr

A reduced finite element model for determining the maximum principal stress of a glass pane subjected to dynamic impact load is developed and compared to a full dynamic finite element model. The reduced model is based on the Rayleigh-Ritz method. The Ritz vectors used are determined by simple static load-cases. The model is applicable to centrically and eccentrically applied impact and to glass of

Gene set-based analysis methods have recently gained increasing popularity for analysis of microarray data. Several studies have indicated that the results from such methods are more reproducible and more easily interpretable than the results from single gene-based methods. A new method for ranking gene sets with respect to their association with a given predictor or response, using a new framewor

We show that light drives large-amplitude structural changes in thin films of the prototypical ferroelectric PbTiO3 via direct coupling to its intrinsic photovoltaic response. Using time-resolved x-ray scattering to visualize atomic displacements on femtosecond time scales, photoinduced changes in the unit-cell tetragonality are observed. These are driven by the motion of photogenerated free charg

Study Design. Multi-center case-control studyObjective. To investigate the prevalence of back problems in adults with idiopathic scoliosis.Summary of Background Data. Information on the prevalence of back problems in adults with idiopathic scoliosis is scarce, especially in untreated individuals, males and individuals with an age at onset of the scoliosis of less than 10 years.Methods. 1069 indivi

The role of structural genetic changes in human disease has received substantial attention in recent decades, but surprisingly little is known about numerical chromosomal abnormalities, even though they have been recognized since the days of Boveri as partaking in different cellular pathophysiological processes such as cancer and genomic disorders. The current knowledge of the genetic and epigenet

Objective: The most widely studied positron emission tomography ligand for in vivo P-amyloid imaging is C-11-Pittsburgh compound B (C-11-PIB). Its availability, however, is limited by the need for an on-site cyclotron. Validation of the F-18-labeled PIB derivative F-18-flutemetamol could significantly enhance access to this novel technology. Methods: Twenty-seven patients with early-stage clinical

We have studied nucleation and crystal growth of calcium carbonate on hard surfaces, i.e. stainless steel and silica, at different temperatures, in relation to the corresponding bulk processes, using scanning electron microscopy (SEM), X-ray diffraction (XRD), and ellipsometry. In the bulk solution, a mixture of all three calcium carbonate crystalline polymorphs, calcite, aragonite, and vaterite,

The dietary fibre composition in parsnip has been determined in the soluble and insoluble fraction, together with the physicochemical properties (morphology of particles, particle size distribution (PSD), volume fraction and rheological properties) of the parsnip suspensions at different paste concentration and degree of homogenization. The content of dietary fibre in parsnip was 30.4% of the dry