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Invertebrate Neurohormone GPCRs

Neurohormones (biogenic amines, neuropeptides, and protein hormones) and their G-protein-coupled receptors (GPCRs) occupy a high hierarchic position in the physiology of invertebrates because they steer important processes such as development, growth, reproduction, feeding, homeostasis, and behavior. In this article, we focus on the neurohormone GPCRs from insects (which comprise 75% of all animal

Two fatty acyl reductases involved in moth pheromone biosynthesis

Fatty acyl reductases (FARs) constitute an evolutionarily conserved gene family found in all kingdoms of life. Members of the FAR gene family play diverse roles, including seed oil synthesis, insect pheromone biosynthesis, and mammalian wax biosynthesis. In insects, FAR genes dedicated to sex pheromone biosynthesis (pheromone-gland-specific fatty acyl reductase, pgFAR) form a unique clade that exh

A Distant Supervision Approach to Semantic Role Labeling

Semanticrolelabelinghasbecomeakeymodule for many language processing applications such as question answering, information extraction, sentiment analysis, and machine translation. To build an unrestricted semantic role labeler, the first step is to develop a comprehensive proposition bank. However, creating such a bank is a costly enterprise, which has only been achieved for a handful of languages.

Patterns of metastasis in colon and rectal cancer

Investigating epidemiology of metastatic colon and rectal cancer is challenging, because cancer registries seldom record metastatic sites. We used a population based approach to assess metastatic spread in colon and rectal cancers. 49,096 patients with colorectal cancer were identified from the nationwide Swedish Cancer Registry. Metastatic sites were identified from the National Patient Register

Genetic Susceptibility to Bortezomib-Induced Peripheral Neuroropathy : Replication of the Reported Candidate Susceptibility Loci

The introduction of proteasome inhibitors in the treatment of multiple myeloma (MM) patients has been a therapeutic success. Peripheral neuropathy (PNP) remains one of the most frequent side-effects experienced by patients who receive these novel agents. Recent investigations on the mechanisms of PNP in patients treated with bortezomib have suggested genetic susceptibility to neurotoxicity. We use

Time scales for Majorana manipulation using Coulomb blockade in gate-controlled superconducting nanowires

We numerically compute the low-energy spectrum of a gate-controlled superconducting topological nanowire segmented into two islands, each Josephson coupled to a bulk superconductor. This device may host two pairs of Majorana bound states and could provide a platform for testing Majorana fusion rules. We analyze the crossover between (i) a charge-dominated regime utilizable for initialization and r

Isotherms and Kinetics of Water Vapor Sorption/Desorption for Surface Films of Polyion-Surfactant Ion Complex Salts

Thin films of "complex salts" (CS = ionic surfactants with polymeric counterions) have recently been shown to respond to humidity changes in ambient air by changing their liquid crystalline structure. We here report isotherms and kinetics of water sorption/desorption for ∼10-100 μm films of alkyltrimethylammonium polyacrylate CS, measured in a dynamic gravimetric vapor sorption instrument over a 0

Time-resolved characterization of primary particle emissions and secondary particle formation from a modern gasoline passenger car

Changes in vehicle emission reduction technologies significantly affect traffic-related emissions in urban areas. In many densely populated areas the amount of traffic is increasing, keeping the emission level high or even increasing. To understand the health effects of traffic-related emissions, both primary (direct) particulate emission and secondary particle formation (from gaseous precursors i

Optimum design and control of grid integrated electrical hubs considering lifecycle cost and emission

Grid connected renewable energy systems are becoming popular due to reasons such as rapid escalation of energy prices, depletion of fossil fuel resources and pollutant emitted by conventional energy sources. Therefore, technologies for incorporating renewable energy technologies into the existing electricity grid needs to be researched more considering the changes in grid architecture. This study

Sensitivity of the dispatch strategy in designing grid integrated hybrid energy systems

Integrating renewable energy technologies based on solar PV (SPV) and wind energy in the energy system is challenging due to time dependence of the energy potential for these energy sources. Grid integrated hybrid energy systems combining SPV panels, wind turbines, battery bank and internal combustion generators (ICG) can be used in this regard specially for distributed generation. Energy-economic

Cancer heterogeneity determined by functional proteomics

Current manuscript gives a synopsis of tumor heterogeneity related to patient samples analyzed by proteomics, protein expression analysis and imaging mass spectrometry.First, we discuss the pathophysiologocal background of cancer biology as a multifactorial and challenging diseases. Disease pathology forms the basis for protein target selection. Therefore, histopathological diagnostics and grading

The European species of Foersterella Dalla Torre (Hymenoptera : Tetracampidae), including the description of two new species

The European species of Foersterella Dalla Torre 1897 (Hymenoptera: Tetracampidae) are treated, including two previ-ously described species, F. erdoesi Bouček and F. reptans (Nees), and two new species, F. angusticornis sp. nov. and F. fuscicornis sp. nov. Morphological concepts of the species are based mainly on characters in the male antenna, which fe-males lack, and with the exception of F. erd

Tundra meets atmosphere : Seasonal dynamics of trace gas exchange in the High Arctic

Arktiska miljöer har de senaste decennierna upplevt en stark temperaturökning, vilket påverkar tundrans kolcykel.Smältande permafrost, minskande snötäcke och förändringar i hydrologiska mönster är exempel på pågående processer som förändrar samspelet mellan mark och atmosfär samt ekosystemens säsongsdynamik.Då ett antal av dessa processer involverar utbyte av växthusgaser, såsom spårgaserna metan Arctic environments have experienced strong warming in recent decades, which is affecting the carbon cycle of tundra ecosystems.Degrading permafrost, diminishing snow cover, and changing hydrology are examples of ongoing processes that affect the land-atmosphere interactions and seasonal ecosystem dynamics.Since a number of the affected processes involve the exchange of atmospheric greenhouse gase

Sponges of the family Axinellidae (Porifera : Demospongiae) in Indonesia

Nine species in five genera of the family Axinellidae, including three new species, Axinella badungensis sp. nov., A. ba-linensis sp. nov. and Phycopsis pesgalli sp. nov. are recorded from Indonesian waters within the limits of the Western Coral Triangle province. Descriptions and discussion of those species are presented here. Four new combinations, Pha-kettia arbora (Sim, Kim & Byeon, 1990)

Water-Mediated Ion Pairing : Occurrence and Relevance

We present an overview of the studies of ion pairing in aqueous media of the past decade. In these studies, interactions between ions, and between ions and water, are investigated with relatively novel approaches, including dielectric relaxation spectroscopy, far-infrared (terahertz) absorption spectroscopy, femtosecond mid-infrared spectroscopy, and X-ray spectroscopy and scattering, as well as m

Type and quantity of organic amendments determine the amount of carbon stabilized in particle-size fractions of a semiarid degraded soil

A 9-month lab experiment was carried out with three different amendments (vine pruning wastes, PW; composted vine pruning wastes, cPW; and sewage sludge, SS) added at three different rates (90, 180, and 240 t ha−1, dry weight) in order to test whether the type or the quantity of the amendments applied to a semiarid, degraded soil determined the Corg accumulation in its particle-size fractions (coa