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GATA-binding protein 3 (GATA3) is a transcription factor that is crucial to mammary gland morphogenesis and differentiation of progenitor cells, and has been suggested to have a tumor suppressor function. The rs570613 single nucleotide polymorphism (SNP) in intron 4 of GATA3 was previously found to be associated with a reduction in breast cancer risk in the Cancer Genetic Markers of Susceptibility
Background: Although cardiovascular disease is thouht to be common in cirrhosis, there are no systematic investigations on the prevalence of electrocardiographic (ECG) abnormalities in these patients and data on the occurrence of post-transplant cardiac events in comparison with the general population are lacking. We aimed to study the prevalence and predictors of ECG abnormalities in patients wit
Immunohistochemical expression of CD40 is seen in 60-70% of diffuse large B-cell lymphoma (DLBCL) and is associated with a superior prognosis. By using gene expression profiling we aimed to further explore the underlying mechanisms for this effect. Ninety-eight immunohistochemically defined CD40 positive or negative DLBCL tumors, 63 and 35 respectively, were examined using spotted 55K oligonucleot
The management of resources among competing QoS-aware applications is often solved by a resource manager (RM) that assigns both the resources and the application service levels. However, this approach requires all applications to inform the RM of the available service levels. Then, the RM has to maximize the "overall quality" by comparing service levels of different applications which are not nece
The combination of in situ geotechnical testing and continuously measured geophysical data can be a powerful tool in geotechnical site investigation. In two cases from Sweden and one case from Denmark electric resistivity surveys are used successfully in geotechnical site investigations. The main contribution of resistivity results is the possibility to interpret continuous geological models. An i
To describe incidence, risk factors, and influence of treatment on occurrence of central nervous system (CNS) relapse or progression in younger patients with aggressive B-cell lymphoma. We analyzed 2210 patients with aggressive B-cell lymphoma treated on various studies for CNS relapse/progression. Treatment consisted of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) +/- etoposi
Popular Abstract in Swedish Diabetes är ett samlingsnamn för sjukdomar som ger förhöjt blodsocker (glukos) som gemensam nämnare. Diabetes ökar stort runt om i världen och ”International Diabetes Federation” (IDF) meddelade att det år 2014 fanns 387 miljoner individer med diabetes globalt och att denna siffra förväntas öka till 592 miljoner individer till år 2035. Ungefär 77% av alla som insjuknar Today type 2 diabetes is a common disease with a worldwide prevalence of 8.3%. The disease is characterised by hyperglycaemia which is a result of insufficient insulin secretion from the beta-cells in the pancreatic islets as well as an insulin resistance seen in the target tissues. Type 2 diabetes is a multifactorial disease with genetic, epigenetic and environmental background. In study I we in
In this study we quantify the partitioning of recent assimilates to above- and below-ground carbon (C) pools in two subarctic mire ecosystems - wet minerotrophic and semiwet ombrotrophic mire - using in situ C-14 pulse-labelling. Ecosystem C partitioning to rhizomes, coarse roots, fine roots, dissolved organic carbon (DOC) and microbes were quantified twice during the growing season at three diffe
We study high-order harmonic generation with a high-repetition rate (200 kHz), few-cycle, driving laser, based on optical parametric chirped pulse amplification. The system delivers carrier-envelope phase stable, 8 fs, 10 mu J pulses at a central wavelength of 890 nm. High-order harmonics, generated in a high-pressure Ar gas jet, exhibit a strong CEP-dependence over a large spectral range owing to
In recent years, there has been growing interest in measuring the efficiency of hospitals in Iran and several studies have been conducted on the topic. The main objective of this paper was to review studies in the field of hospital efficiency and examine the estimated technical efficiency (TE) of Iranian hospitals.
Background: The higher risk of death resulting from excess adiposity may be attenuated by physical activity (PA). However, the theoretical number of deaths reduced by eliminating physical inactivity compared with overall and abdominal obesity remains unclear. Objective: We examined whether overall and abdominal adiposity modified the association between PA and all-cause mortality and estimated the
Breast cancer is the most common cancer form among women in the Western world. Although treatment has improved during the last decades, there is still a significant proportion of the patients who are not cured. To further improve clinical outcome we need new treatment strategies, new prognostic markers, and new treatment predictive factors for personalized medicine.In this dissertation I have focu
A 41-year-old woman with SAPHO syndrome presented with numbness of her left arm followed by a generalized seizure. Computed tomography and magnetic resonance imaging of the brain revealed a small ring enhancing lesion in the right parietal lobe with adjacent meningeal thickening and enhancement. Surgical removal and histopathology showed evidence of severe chronic sterile inflammation and no malig
Residual stresses have in the past been introduced to manipulate growth rates and shapes of cracks under cyclic loads. Previously, the effectiveness of shot peening in retarding the rate of fatigue crack growth was experimentally studied. It was shown that the compressive residual stresses arising from the shot peening process can affect the rate of crack growth. Laser shock peening can produce a
Environmental impacts from incineration, decentralised composting and centralised anaerobic digestion of solid organic household waste are compared using the EASEWASTE LCA-tool. The comparison is based on a full scale case study in southern Sweden and used input-data related to aspects such as source-separation behaviour, transport distances, etc. are site-specific. Results show that biological tr
Differently homogenised and heat treated potato pulp, used as a dietary fibre additive in low-fat sausages, gave rise to an enhanced instrumentally and sensory measured firmness and compactness, respectively. This is believed to be due to the high content of insoluble fibre, which creates a fibrous network that enhances the texture of the sausage, while not interfering with the meat protein networ
The BH3 interacting-domain death agonist (BID) is a pro-apoptotic protein involved in death receptor-induced and mitochondria-mediated apoptosis. Recently, it has also been suggested that BID is involved in the regulation of inflammatory responses in the central nervous system. We found that BID deficiency protected organotypic hippocampal slice cultures in vitro from neuronal injury induced by ox
To outline a framework for preparedness planning at the organizational level.
