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Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies extracellular MRP8/14 as an autocrine player in the leukocyte adhesion cascade. We show that E-selectin-PSGL-1 interaction during neutrophil rolling triggers Mrp8/14 sec

Popular Abstract in Swedish Många forskningsprojekt inom materialvetenskap, medicin eller grundläggande fysik kräver smala strålar av laddade partiklar som fungerar som provtagare för att undersöka materiens egenskaper. Dessa partiklar kan vara protoner, elektroner lättare joner. Relativt ofta, behöver de accelereras nästan upp till ljusets hastighet för att kunna tränga in tillräckligt djupt i prLaser-driven particle acceleration makes use of sub-picosecond, pulsed, high-power laser systems, capable of producing intensities ~10^{19} W/cm^2 at the laser focus to form plasmas, and use ultra-relativistic and nonlinear dynamics to produce quasistatic acceleration fields. This allows electrons to be accelerated to ~100 MeV over sub-centimetre distances, while protons may be accelerated to the

Objective: This study evaluated the tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in patients with COPD. Methods: This double-blind, placebo-controlled study (NCT00629239) randomised patients with moderate to severe COPD to AZD4818 300 mu g or placebo twice daily via Turbuhaler (R) for 4 weeks. Safety, lung function, functional capacity and health status measures were measured.

Interannual variations in CO2 exchange across Amazonia, as deduced from atmospheric inversions, correlate with El Nino occurrence. They are thought to result from changes in net ecosystem exchange and fire incidence that are both related to drought intensity. Alterations to net ecosystem production (NEP) are caused by changes in gross primary production (GPP) and ecosystem respiration (R-eco). Her

ABSTRACT: BACKGROUND: Objective was to describe variations in how social insurance officers conceive the cooperation with the health care in their daily work with sick leave. METHODS: Fifteen social insurance officers (SIOs) working with administration of sickness benefits were interviewed. They were purposefully recruited to represent different parts of the social insurance office organization, d

Therapy-induced resistance remains a significant hurdle to achieve long-lasting responses and cures in cancer patients. We investigated the long-term consequences of genetically impaired angiogenesis by engineering multiple tumor models deprived of endoglin, a co-receptor for TGF-beta in endothelial cells actively engaged in angiogenesis. Tumors from endoglin-deficient mice adapted to the weakened

Direct photons are a powerful probe to study the property of quark–gluon plasma (QGP) in high energy heavy-ion collisions. In non-central collisions, the anisotropy of the collision region produces the different pressure gradients and particle density that results in different anisotropy of particle emission, depending on the production processes of photons. Therefore, an azimuthal anisotropy para

Three recent randomised trials have shown a lack of effect of EGDT for the treatment of severe sepsis and septic shock. Notably, control group care was excellent in all trials, including early recognition, early and aggressive fluid resuscitation and prompt administration of antibiotics, and was reflected in a lower than expected mortality.The discussion emphasizes the need for continued vigilanceThree recent randomised trials have shown a lack of effect of EGDT for the treatment of severe sepsis and septic shock. Notably, control group care was excellent in all trials, including early recognition, early and aggressive fluid resuscitation and prompt administration of antibiotics, and was reflected in a lower than expected mortality.The discussion emphasizes the need for continued vigilance

Cerebellar Purkinje cells can learn to respond to a conditioned stimulus with an adaptively timed pause in firing. This response was usually ascribed to long-term depression of parallel fiber to Purkinje cell synapses but has recently been shown to be due to a previously unknown form of learning involving an intrinsic cellular timing mechanism. Here, we investigate how these responses are elicited

Patients with antineutrophil cytoplasm antibody-associated vasculitis (AAV) requiring dialysis at diagnosis are at risk for developing end-stage renal disease (ESRD) or dying. Shortterm results of a trial comparing plasma exchange (PLEX) to intravenous methylprednisolone (IV MeP) suggested PLEX improved renal recovery. Here we conducted long-term follow-up to see if this trend persisted. A total o

This paper addresses a problem related to control of web servers. Due to architectual issues, relevant measurements can only be taken over a limited part of the server system, which leaves the controller unaware of what happens in buffers proceeding the actual web-server (for instance, in the TCP/IP layers). In earlier presented work we modeled such a system and proved that the unmeasured bufferin

OBJECTIVE - The purpose of this study was to compare the incidence of vascular lower-limb amputation (LLA) in the diabetic and nondiabetic general population. RESEARCH DESIGN AND METHODS - A population-based cohort study was conducted in a representative Swedish region. All vascular LLAs (at or proximal to the transmetatarsal level) performed from 1997 through 2006 were consecutively registered an

Popular Abstract in Swedish De övergripand syftena med dessa studier var att undersöka vilka konsekvenser höftbesvär och höftledsartros har på hälsorelaterad livskvalité, fysisk förmåga och tilltro till egen förmåga. Höftledsartros är ofta förknippad med svår smärta och påverkar både fysiska funktioner och livskvalité. Förekomsten av höftbesvär, i en befolkningsgrupp i södra Sverige, var 32%, och The overall aims of this work were to investigate the consequences of hip disorders and hip osteoarthritis (OA) on health-related quality of life (HRQL) physical function and self-efficacy. The condition, hip OA, is often associated with significant pain and has a strong impact on physical function and quality of life. The prevalence of hip disorders were 32% and among the individuals reporting h

Popular Abstract in Undetermined I den här populärvetenskapliga sammanfattningen berörs avhandlingen Gradient Methods for Large-Scale and Distributed Linear Quadratic Control. Hur kan jetflygplan hålla sig i luften? Hur kan en Segway balansera en människa? Dessa frågor och många fler kan besvaras med hjälp av reglerteknik. Reglerteknik är ett område som behandlar hur man automatiskt styr system oThis thesis considers methods for synthesis of linear quadratic controllers for large-scale, interconnected systems. Conventional methods that solve the linear quadratic control problem are only applicable to systems with moderate size, due to the rapid increase in both computational time and memory requirements as the system size increases. The methods presented in this thesis show a much slower

Entrepreneurship is an emerging research field that has received much scholarly attention in recent decades. Given the global scope of this attention, this article compares entrepreneurship research in China with that in the USA and Europe. Based on publications in Social Science Citation Index and Chinese Social Science Citation Index databases over the past 10 years, we use bibliometric method t