Kidney failure and associated uraemia have implications for the cardiovascular system, brain, and blood-brain barrier (BBB). We aim to examine BBB disruption, by assessing brain-derived neurotropic factor (BDNF), neuron-specific enolase (NSE) levels, and gut-blood barrier (GBB) disruption by trimethylamine N-oxide (TMAO), in chronic kidney disease (CKD) patients. Additionally, endothelial tight-ju

Cartilage provides low-friction properties and plays an essential role in diarthrodial joints. A hydrated ground substance composed mainly of proteoglycans (PGs) and a fibrillar collagen network are the main constituents of cartilage. Unfortunately, traumatic joint loading can destroy this complex structure and produce lesions in tissue, leading later to changes in tissue composition and, ultimate

The interaction between DNA methylation of tripartite motif containing 27 (cg05293407TRIM27) and smoking has previously been identified to reveal histologically heterogeneous effects of TRIM27 DNA methylation on early-stage non-small-cell lung cancer (NSCLC) survival. However, to understand the complex mechanisms underlying NSCLC progression, we searched three-way interactions. A two-phase study w

Rationale: Coronavirus disease (COVID-19) is an ongoing pandemic, in which obesity, hypertension, and diabetes have been linked to poor outcomes. Obstructive sleep apnea (OSA) is associated with these conditions and may influence the prognosis of adults with COVID-19. Objectives: To determine the effect of OSA on clinical outcomes in patients with COVID-19. Methods: The current prospective observa

Early childhood educational centers (ECEC) are contexts where young children make their first contact with specific, culturally determined rules, practices, and values. Only a few studies have analyzed in-depth the practices through which the educators direct the children’s action and attention while they are performing routine educational activities. By means of detailed transcription of educator

Per-Olof Hedvall ger en inblick i hur universell design startade och hur det tankeskiftet tar klivet in i arbetslivet med UUA. Om hur vi kan göra arbetslivet mer tillgängligt från början och minska risken för kategoriseringar och särbehandling.

Displacement is one of the most pressing challenges faced by the society today. REGARD (REbuildinGAfteR Displacement) is a collaborative research project co-funded by EU Erasmus+ programme, which set out to investigate the role of built environment in the context of displacement. The REGARD project launched in September 2018 with an aim to develop competencies in rebuilding communities following a

Synthesis of diketopiperazines has been of long-standing interest in both natural product synthesis and medicinal chemistry. Here, we present an operationally convenient and efficient approach to the fused indoline-diketopiperazine tricyclic core of glionitrin A/B and related structures using a Pd-catalyzed C-H activation reaction to form the indoline five-membered ring. Exploratory work aimed at

The ripeness of fruits is commonly assessed by the visual appearance, but this method is not very accurate and there can be a large variability. We have developed a hand-held sensor based on laser-induced fluorescence to provide more objective guidance. The instrument incorporates a 412 nm continuous wave semiconductor laser and a miniature spectrometer. It was used for monitoring of tropical frui

The performance and reliability of wireless communications at sea are often limited by the deep fades caused by the coherent sea surface reflection. In this paper, we show that by employing multiple antennas at the base station, the deep fades can be mitigated within a large communication range if the antennas are carefully spaced in the vertical direction. We derive a bound for the range where mi

Wine particle matter is mainly constituted by wine colloids and wine macromolecules. These wine colloidal and macromolecular compounds are barely studied, possibly due to the difficulty in facing the challenges that their study merits. These compounds are mainly formed by polyphenols, proteins and polysaccharides that come from the grape seeds, skins and pulp and even, to a lesser extent, from the

Globally, households are shrinking – more and more people are living alone. In 2016, almost two thirds of all households in the EU were composed of one or two people, with shrinking households also prevalent around the world. As countries move up the human development index, households are expected to continue to shrink.

Previous research with typically developing children and adults shows that active control of the learning experience leads to enhanced episodic memory, as compared with conditions lacking this control. The present study investigates whether similar advantages can be found in children with autism spectrum disorder. In this study, 6–12-year-old autistic children (N = 29) participated in a simple mem

HYPOTHESIS: Top-down fabrication of polymer nanoparticles from preformed polymers by spontaneous colloid formation under influence of the Ouzo effect is a widely applied concept whereas bottom-up free-radical polymerization of monomers nucleated under the Ouzo regime have found limited application after a seminal report almost half a century ago. We hypothesized that the approach would be of value

Ab initio simulations of a range of interferometric experiments are used to identify a strong dependence on multiphoton phase shifts in above-threshold ionization (ATI). A simple rule of thumb for interaction phase shifts is derived to explain both the conservation of photoelectron yield and its absolute CEP dependence. For instance, it is found that interferometric (ATI) experiments are shifted b