Infection-induced kinin B-1 receptors in human pulmonary fibroblasts: Role of intact pathogens and p38 mitogen-activated protein kinase-dependent signaling
Kinin B-1 receptors (B1R) are involved in many pathophysiological processes, and its expression is up-regulated in inflammatory pulmonary disease. Although bacteria can generate kinin peptides, the molecular signaling mechanisms regulating B1R during infection by intact pathogens is unknown. The serious opportunistic clinical isolate Burkholderia cenocepacia (B. cen.) belongs to the important B. c