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Huntington's disease (HD) is caused by a polyglutamine expansion in the protein huntingtin. In its terminal stage, HD is characterized by widespread neuronal death in the neocortex and the striatum. Classically, this neuronal death has been thought to underlie most of the symptoms of the disease. Accumulating evidence suggests, however, that cellular dysfunction is important in the pathogenesis of

In the present study, we compare functional consequences of dissociation and reconstitution of binding proteins FKBP12 and FKBP12.6 with ryanodine receptors from cardiac (RyR2) and skeletal muscle (RyR1). The skeletal muscle RyR1 channel became activated on removal of endogenously bound FKBP12, consistent with previous reports. Both FKBP12 and FKBP12.6 rebind to FKBP-depleted RyR1 and restore its

The major aim of the study was to investigate whether differences concerning acceptance of dental treatment and amnesia after rectal sedation with midazolam can be explained by temperament traits in the child. Fifty children (1.5- 4.0 years), consecutively referred for dental extractions because of dental trauma or caries, were sedated with midazolam 0.3 mg kg(1) rectally. Level of sedation (state

We present an abundance analysis of the very metal-poor, carbon-enhancedstar CS 29497-030. Our results indicate that this unusually hot turnoffstar (T_eff = 6650 K, log g = 3.5) has a metallicity [Fe/H] =-2.8, and exhibits large overabundances of carbon ([C/Fe] = +2.38),nitrogen ([N/Fe] = +1.88), and oxygen ([O/Fe] = +1.67). This star alsoexhibits a large enhancement in its neutron-captu

Enamel matrix derivative, obtained from developing porcine teeth, is composed mainly of amelogenin proteins and used topically in periodontal surgery for advanced periodontitis to regenerate lost connective tissues. The primary objective of this study was to investigate the effects of enamel matrix derivative on skin wound healing. Secondly, in vitro effects of enamel matrix derivative on dermal f

Purpose: The incidence of urinary incontinence increases with age but the cause and effect relationship between aging and altered bladder function is poorly understood. It was suggested that melatonin can ameliorate negative effects induced by aging by its free radical scavenging activity and its ability to decrease oxidative stress. We investigated the changes in bladder function evoked by aging

The thermal reaction of Co film deposited on Si(111) surfaces by a high current filter metal vacuum arc (FMEVAD) system has been studied. After deposition the films were annealed over the 400-900 degrees C temperature range for 30 min. Rutherford backscattering spectrometry (RBS) was used to characterize the elemental depth distributions in the films subjected to different annealing temperatures.

Slides from two lectures given at the commemoration of the Nyquist Hall at Karlstad Institute of Technology. The first lecture presents Nyquist's stability criterion and discusses its consequences for the field of Automatic Control. The second lecture (in Swedish) gives a shorter but broader presentation of Nyquist's contributions to communication and control.

The current knowledge on lipoprotein secretion from the heart is examined in this article. The ability of cells to secrete apolipoprotein B (apo-B) containing lipoproteins depends on expression of the apo-B and microsomal triglyceride transfer protein (MTP) genes. Initially, it was shown that both genes are expressed in cardiac myocytes of mice and humans. Electron microscopy of human cardiac myoc

Excited states of Ga-65 and Ga-67 nuclei were populated through the C-12(Ni-58,alpha p) and C-12(Ni-58,3p) reactions, respectively, and investigated by in-beam gamma-ray spectroscopic methods. The NORDBALL array equipped with a charged particle ball and 11 neutron detectors was used to detect the evaporated particles and gamma rays. The level schemes of Ga-6.5.67 were constructed On the basis of g

Are you interested in or curious about Batch Control, ISA S88, and/or Plant Automation in general, then this whitepaper is for you.

In the following three pages you will learn the basics about Batch Control and ISA S88 and you will understand how you can benefit from knowing them. For a deeper understanding I recommend you to read the other whitepapers in this series as well as reading the ISA

During the spring of 2003 ninety-five water bodies in southeastern Estonia were surveyed for chrysophytes. The sampling was carried out as the ice broke up, when, within two weeks, the water temperature rose from 3 degrees C to 13 degrees C. Large lakes to small pools of different water chemistry were investigated. The plankton collected was studied alive within a few hours after sampling. Prepara

The Department of English in Lund: Working Papers in Linguistics is an annual volume produced by the English Department at Lund University in Sweden. Its main aim is to publicize research being carried out by staff and post-graduate students in the department, but we are also pleased to include contributions from members of neighbouring departments and universities. The contributions in volume 3