Pridopidine is a small molecule in clinical development for the treatment of Huntington’s disease. It was recently found to have high binding affinity to the sigma-1 receptor, a chaperone protein involved in cellular defense mechanisms and neuroplasticity. Here, we have evaluated the neuroprotective and neurorestorative effects of pridopidine in a unilateral 6-hydroxydopamine (6-OHDA) lesion model

Diabetes is associated with decrements in cognitive function and with abnormalities in brain morphology. In addition, alterations of metabolism have been reported in the diabetic brain. Magnetic Resonance Spectroscopy (MRS) is a non-invasive technique that can be employed to determine the concentration of metabolites in a fully non-invasive manner under normal physiological conditions. The present

Cerebral glucose homeostasis is maintained by the equilibrium between glucose transport across the blood-brain-barrier (BBB), which occurs through facilitative carriers, and glucose consumption mainly initiated by hexokinase phosphorylation. Glucose concentrations can be quantified non invasively by nuclear magnetic resonance (NMR) spectroscopy and such measurements, through appropriate mathematic

The aim of the study was to identify changes in agricultural practices and periods of agricultural expansion and regression during the last 1,300 years in the South-Swedish Uplands. Sediments from the small lake of Skärpingsgölen (1.2 ha) were used to quantify land-cover at a local scale (c. 1 km radius) in 50-year intervals based on pollen analysis and the LOVE model (Local Vegetation Estimates).

Background: The SQ tree sublingual immunotherapy (SLIT)–tablet (ALK-Abelló, Hørsholm, Denmark) is developed for treatment of tree pollen–induced allergic rhinoconjunctivitis (ARC). Objective: The aim of this pivotal phase III trial was to demonstrate the efficacy and safety of the SQ tree SLIT-tablet. Methods: This was a randomized, double-blind, placebo-controlled trial with 634 subjects (12-65 y

“International Msc Educational Programme in Environmental Management and Modelling” (GeoNetC) is a European Commission funded project under ERASMUS+: Higher Education – International Capacity Building programme (Project No 561967-EPP-1-2015-1-SE-EPPKA2-CBHE-JP). It began in October 2015 and ended in October 2018. Initiated by the Lund University and partners from the Middle East countries, the Geo

”De skäl som anförs i ’Tandläkarens olycka’ (NJA 2014 s. 364) rörande bevisbördans placering bygger i huvudsak på att ett påstående om försträckning står emot ett påstående av benefik karaktär …. De kan därför inte anses göra sig gällande med samma styrka när ett påstående om försträckning står emot ett påstående om betalning. […] Mot denna bakgrund finns anledning att i nu diskuterade fall falla

This study explores the impact an exogenous improvement in childhood health has on later-life outcomes. Using extensive and detailed register data from the Swedish Interdisciplinary Panel, we follow individuals exposed to the introduction of the first vaccine against polio in Sweden (birth cohorts 1937-1966) until adulthood in order to quantify the causal effect of polio vaccination on long-term e

The increase in average global temperature and higherfrequency of heat waves predicted by the majority ofmeteorological models will increase the effect of heat stresson human beings. For specifically addressing the impact ofthis environmental health risk on individuals, improvedmethods including individual factors such as clothing andmetabolic rate are needed. This presentation gives anoverview of