CYLD is a deubiquitination enzyme that regulates different cellular processes, such as cell proliferation and cell survival. Mutation and loss of heterozygosity of the CYLD gene causes development of cylindromatosis, a benign tumour originating from the skin. Our study shows that CYLD expression is dramatically downregulated in basal cell carcinoma (BCC), the most common cancer in humans. Reduced

This article examines the selection, marketing and reception of African fiction on the Swedish book market of the 1960s and 70s, through the series Afrika berättar, launched by Bo Cavefors Publishing, Ltd. Bo Cavefors was a Swedish publisher of writers such as Wole Soyinka, Ngũgĩ wa Thiong’o and José Luandino Vieira. The article discusses the way in which these literary works were received taking

The functional role of herbivores in tropical rainforests remains poorly understood. We quantified the magnitude of, and underlying controls on, carbon, nitrogen and phosphorus cycled by invertebrate herbivory along a 2800m elevational gradient in the tropical Andes spanning 12 degrees C mean annual temperature. We find, firstly, that leaf area loss is greater at warmer sites with lower foliar pho

Migration causes temporal and energetic constraints during plumage development, which can compromise feather structure and function. In turn, given the importance of a good quality of flight feathers in migratory movements, selection may have favoured the synthesis of feathers with better mechanical properties than expected from a feather production constrained by migration necessities. However, n

The province of Jamtland, central Sweden, records a well-preserved but very thin suite of the Lower-Middle Ordovician cool-water carbonates. In this study we present the first carbon isotope profile for these strata on the basis of whole-rock samples from the Brunflo 2 core. The studied succession is 41.55 m thick and includes, in ascending order, the Bjorkasholmen Formation, Latorp Limestone, Toy

The incidence of Hodgkin lymphoma has increased among adolescents and young adults in recent decades, but the relevant risk factors in early life are still unknown. A national cohort study was conducted of 3,571,574 individuals born in Sweden in 19732008 and followed up for Hodgkin lymphoma incidence through 2009, to examine perinatal and family risk factors for Hodgkin lymphoma in childhood throu

Athletes constantly report experiences of momentum during athletic contests, and they consider momentum as being an important factor for the outcome of a competition. However, researchers trying to capture momentum with quantitative methods see themselves confronted with inconclusive results. To explain this gap between athletes’ belief and results from quantitative data, it is hypothesised that m

We report the measurement of the transverse momentum dependence of inclusive J/psi polarization in p + p collisions at root s = 200 GeV performed by the PHENIX Experiment at the Relativistic Heavy Ion Collider. The J/psi polarization is studied in the helicity, Gottfried-Jackson, and Collins-Soper frames for p(T) < 5 GeV/c and vertical bar y vertical bar < 0.35. The polarization in the helicity an

Departure decisions of how and when to leave a stopover site may be of critical importance for the migration performance of birds. We used an automated radiotelemetry system at Falsterbo peninsula, Sweden, to study stopover behaviour and route choice in free-flying passerines departing on flights across the Baltic Sea during autumn migration. In addition, we had an offshore receiver station (FINO

Purpose This study seeks to investigate the long-term public health burden of Hodgkin lymphoma (HL) in terms of work loss following contemporary treatment protocols and associations with established treatment complications and lymphoma relapse. Methods We identified 1,989 Swedish HL patients (1,082 with clinical information) aged 18-60 (median 33) years at diagnosis 1992-2009, and matched 1:4 to p

This review covers the recent literature on the geography of sustainability transitions and takes stock with achieved theoretical and empirical insights. The review synthesises and reflects upon insights of relevance for sustainability transitions following from analyses of the importance of place specificity and the geography of inter-organisational relations. It is found that these contributions

Abstract in UndeterminedA topology optimization method allowing for perimeter control is presented. The approach is based on a functional that takes the material density and the strain field as arguments. The cost for surfaces is included in the functional that is minimized. Diffuse designs are avoided by introducing a penalty term in the functional that is minimized. Equilibrium and a volume cons

The frequency dependence of the longitudinal relaxation rate, known as the magnetic relaxation dispersion (MRD), can provide a frequency-resolved characterization of molecular motions in complex biological and colloidal systems on time scales ranging from 1 ns to 100 μs. The conformational dynamics of immobilized proteins and other biopolymers can thus be probed in vitro or in vivo by exploiting i

Epidemiological studies suggest that low levels of vitamin D (25OHD) constitute a risk factor for more aggressive prostate cancer. We examined the relationship between pre-diagnostic serum levels of vitamin D, parathyroid hormone (PTH), and calcium and risk of prostate cancer according to tumor aggressiveness.

The aim of this work is to present the use of proper orthogonal decomposition (POD) and extended proper orthogonal decomposition (EPOD) for revealing flame dynamics as a set of statistical quantities referred as modes. The flame fluctuations are used to derive an empirical functions base representing the most important features of the flame. The capabilities of the technique are exemplified in the

Stomatal conductance (g(s)) is a key land-surface attribute as it links transpiration, the dominant component of global land evapotranspiration, and photosynthesis, the driving force of the global carbon cycle. Despite the pivotal role of g(s) in predictions of global water and carbon cycle changes, a global-scale database and an associated globally applicable model of g(s) that allow predictions

Approximately 1700 Pg of soil carbon (C) are stored in the northern circumpolar permafrost zone, more than twice as much C than in the atmosphere. The overall amount, rate, and form of C released to the atmosphere in a warmer world will influence the strength of the permafrost C feedback to climate change. We used a survey to quantify variability in the perception of the vulnerability of permafros

BACKGROUND: Intestinal injury is a key feature in sepsis. Inhibitors of heat shock protein 90 (Hsp90) have been shown to exert protective effects in models of inflammation. Herein, we hypothesized that Hsp90 might regulate intestinal inflammation and leakage in abdominal sepsis. MATERIALS AND METHODS: Male C57BL/6 mice were pretreated with radicicol (60 mg/kg), which is a specific inhibitor of Hsp