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Method comparison study of the Elecsys® β-Amyloid (1–42) CSF assay versus comparator assays and LC-MS/MS

Background: Alzheimer's disease (AD) biomarkers, such as cerebrospinal fluid (CSF) amyloid-β (1–42; Aβ42), can provide high diagnostic accuracy. Several immunoassays are available for Aβ42 quantitation, but standardisation across assays remains an issue. We compared the Elecsys® β-Amyloid (1–42) CSF assay with three assays and two liquid chromatography tandem mass spectrometry (LC-MS/MS) methods.

Exploring analytical avenues for agonistic peace

The main contribution of this article is a rethinking of the peace concept, geared towards the creation of a framework for the analysis of agonistic peace. The literature on agonistic peace has thus far been elaborate in terms of theoretical sophistication. However, the dearth of empirical research on the concept is quite remarkable. This study takes that lacuna as a starting point for the groundi

Key performance indicators for manufacturing operations management - Gap analysis between process industrial needs and ISO 22400 standard

ISO 22400 has defined a set of Key Performance Indicators (KPIs) to evaluate the performance of manufacturing operation. Despite it's conceived to be industry-neutral, the defined KPIs seem not to be perfectly suitable for process industry. Based on a survey performed in a process industrial company, this paper highlights the specific process industry's needs for evaluating the operational perform

Historical climate changes and hybridization shaped the evolution of Atlantic Forest spinetails (Aves : Furnariidae)

Combining phylogeographic approaches and hybrid zone inference in a single framework is a robust way to depict respectively the biogeographic history of lineages and the evolutionary processes responsible for speciation. Here, we studied the spatiotemporal patterns of diversification and characterize the hybrid zone between two Atlantic Forest spinetails (Synallaxis ruficapilla and Synallaxis cine

Levothyroxine treatment and incident dementia in adults with atrial fibrillation

Objective: Levothyroxine treatment is common among older adults as is atrial fibrillation (AF), yet less is known about its potential effects on the development of dementia. Methods: The study population included all adults with diagnosed AF (n = 156,104) aged ≥ 45 years in Sweden without an earlier recorded diagnosis of dementia. Individuals with a dispensed prescription of levothyroxine on two o