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Improved estimation of glomerular filtration rate (GFR) by comparison of eGFR(cystatin C) and eGFR(creatinine)

Objective. GFR-prediction equations based upon cystatin C and creatinine have better diagnostic performance in estimating GFR than equations based upon only one of the two markers. The present work concerns in what way a comparison between separate estimations of GFR based upon cystatin C (eGFR(cystatin C)) or creatinine (eGFR(creatinine)) can be used to evaluate the diagnostic performance of a co

Magnetic properties of MnAs nanocrystals embedded in GaAs

A phenomenological model for explaining the magnetic properties of MnAs nanocrystals embedded in GaAs is proposed. It is shown that experimental data of DC magnetization as a function of temperature, obtained according to zero-field-cooled and field-cooled protocols, can be understood assuming a transition of the system from a low temperature state in which very slow dynamics is observed(frozen st

Self-Calibrated Robotic Manipulator Force Observer

In the robotic manipulation context, end-effector contact forces may be difficult to measure mainly due to the tool dynamic interferences Such as the inertial forces. In this paper, a whole methodology is proposed to estimate these forces. The new approach is based oil a sensor fusion technique that integrates the information of a wrist force sensor. of a 3D accelerometer placed at the robot tool

Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells.

Galiellalactone (GL) is a fungal metabolite that presents antitumor activities on prostate cancer in vitro and in vivo. In this study we show that GL induced cell cycle arrest in G2/M phase, caspase-dependent apoptosis and also affected the microtubule organization and migration ability in DU145 cells. GL did not induce double strand DNA break but activated the ATR and ATM-mediated DNA damage resp

Probing the mass-loss history of the unusual Mira variable R Hya through its infrared CO wind

Context. The unusual Mira variable R Hya is well known for its declining period between AD 1770 and 1950, which is possibly attributed to a recent thermal pulse. Aims. The goal of this study is to probe the circumstellar envelope (CSE) around R Hya and to check for a correlation between the derived density structure and the declining period. Methods. We investigate the CSE around R Hya by performi

HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: Analysis of the Type 1 Diabetes Genetics Consortium families

OBJECTIVE-The Type 1 Diabetes Genetics Consortium has collected type 1 diabetic families worldwide for genetic analysis. The major genetic determinants of type 1 diabetes are alleles at the HLA-DRB1 and DQB1 loci, with both susceptible and protective DR-DQ haplotypes present in all human populations. The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genotypes

Direct Detection Of Single-Nucleotide Polymorphisms In Bacterial DNA By SNPtrap

A major challenge with single-nucleotide polymorphism (SNP) fingerprinting of bacteria and higher organisms is the combination of genome-wide screenings with the potential of multiplexing and accurate SNP detection. Single-nucleotide extension by the minisequencing principle represents a technology that both is highly accurate and enables multiplexing. A current bottleneck for direct genome analys

Increased markers of inflammation and endothelial dysfunction in patients with mild primary hyperparathyroidism

Objectives: The association between primary hyperparathyroidism (PHPT) and cardiovascular disease is incompletely understood. The aims of this study were to evaluate how cardiac function and markers of inflammation and endothelial dysfunction correlate in patients with mild PHPT, and how these markers are influenced by surgical cure of the parathyroid disease (PTX). Material and methods: Forty-fiv

Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line.

Aluminium-based adjuvants (ABA) are the predominant adjuvants used in human vaccinations. While a consensus is yet to be reached on the aetiology of the biological activities of ABA several studies have identified shape, crystallinity and size as critical factors affecting their adjuvanticity. In spite of recent advances, the fate of ABA following their administration remains unclear. Few if any s

Inductive pointing device for tongue control system for computers and assistive devices

Experimental results for pointing tasks using a tongue control system are reported in this paper. Ten untrained subjects participated in the experiment. Both typing and pointing tasks were performed, in three short-term training sessions, in consecutive days, by each subject. The system provided a key pad (14 sensors) and a mouse pad (10 sensors with joystick functionality) whose placements were i

Intensive glucose therapy and clinical implications of recent data: a consensus statement from the Global Task Force on Glycaemic Control

Background: There is compelling evidence showing that achieving good glycaemic control reduces the risk of microvascular complications in people with type 1 and type 2 diabetes. Likewise, there is clear evidence to show that achieving good glycaemic control reduces the risk of macrovascular complications in type 1 diabetes. The UKPDS 10-year follow up suggests that good glycaemic control also redu

Mutations and polymorphisms in TP53 gene-an overview on the role in colorectal cancer

A functionally normal TP53 is essential to protect organisms from developing cancer. Somatic mutations in the gene represent one of the highest recurring perturbations in human tumours, including colorectal cancer (CRC). However, the variegated phenotype of wide spectrum of somatic mutations in TP53 and the complexity of the disease prevent a straight interpretation of the mutational analysis in t

Investigation of Medication Dosage Influences from Biological Weather

Airborne pollen has been associated with allergic symptoms in sensitized individuals, whereas atmospheric pollution indisputably aggravates the impact on the overall quality of life. Therefore, it is of major importance to correlate, forecast and disseminate information concerning high concentration levels of allergic pollen types and air pollutants to the public, in order to safeguard the quality

Physiotherapy in a Danish private context - a social and ethical practice

Popular Abstract in Danish Fysioterapi er en social og etisk praksis som udfolder sig under specifikke historiske, politiske, socialkulturelle og økonomiske forhold. Dansk fysioterapi i en privat kontekst er praktiseret, administreret og håndteret indenfor en neoliberal ideologi, der genererer udfordringer for både fysioterapeuter og borgere: Det forventes implicit at begge parter understøtter denPhysiotherapy is a social and ethical practice which unfolds under specific historical, political, socio-cultural and economic circumstances. Danish physiotherapy in a private context is practiced, administered and managed within a neoliberal ideology which generates challenges for both physiotherapists and their patients. This thesis aims to explore how physiotherapy in a Danish private context s

Simulated carbon emissions from land-use change are substantially enhanced by accounting for agricultural management

It is over three decades since a large terrestrial carbon sink (S-T) was first reported. The magnitude of the net sink is now relatively well known, and its importance for dampening atmospheric CO2 accumulation, and hence climate change, widely recognised. But the contributions of underlying processes are not well defined, particularly the role of emissions from land-use change (E-LUC) versus the

Is smoking a risk factor for collagenous colitis?

Objective. The association between smoking and idiopathic inflammatory bowel disease is well known; smoking seems to have a diverse effect. Crohn's disease is associated with smoking, while ulcerative colitis is associated with non-smoking. Data on smoking in microscopic colitis of the collagenous type (CC) are lacking. The aim of this investigation was to study smoking habits in CC and to observe

Sequential multiphoton multiple ionization of atomic argon and xenon irradiated by X-ray free-electron laser pulses from SACLA

We have investigated multiphoton multiple ionization of argon and xenon atoms at 5 keV using a new x-ray free electron laser (XFEL) facility, the SPring-8 Angstrom Compact free electron LAser (SACLA) in Japan. The experimental results are compared with the new theoretical results presented here. The absolute fluence of the XFEL pulse has been determined with the help of the calculations utilizing

Rutinmässig rektalpalpation vid akut buk har inget visat värde. En genomgång av litteraturen.

I klinisk praxis görs palpation per rektum rutinmässigt på vuxna patienter vid akut buk. Vi utvärderade evidensen för detta genom en systematisk litteratursökning och identifierade 16 relevanta originalstudier. Dessa visade att det saknas evidens för diagnostisk nytta av rektalpalpation vid akut buk, inklusive misstänkt appendicit. Rutinmässig rektalpalpation bör inte göras vid akut buk hos vuxnaA digital rectal examination (DRE) is standard practice in cases of acute abdomen in adult patients. We analyzed the evidence for this by a systematic literature search, and identified 16 relevant original studies. These studies showed that there is no evidence for a diagnostic value of DRE in adult patients with acute abdomen. We should stop doing routine DRE in adult cases of acute abdomen.