The pathophysiology of congenital diaphragmatic hernia (CDH) is constituted by pulmonary hypoplasia and pulmonary hypertension (PH). We previously reported successful treatment with imatinib of a patient with CDH. This study examines the effect of antenatal imatinib administration on the pulmonary vasculature in a rat model of CDH. Pregnant rats were given nitrofen to induce CDH. Controls were giv

Heparin is a well established growth inhibitor of arterial smooth muscle cells (SMCs) both in animal models and in vitro. Even though the cellular mechanisms involved in the anti-proliferative properties of heparin are being resolved, the structural requirements for the biological effects of heparin are not known in detail. Here, we have studied the effect of chemically modified heparins of differ

Background: Enhancer of zeste 2 (EZH2) promotes prostate cancer progression. We hypothesized that increased EZH2 expression is associated with postradiotherapy metastatic disease recurrence, and may promote radioresistance. Methods: EZH2 expression was investigated using immunohistochemistry in diagnostic prostate biopsies of 113 prostate cancer patients treated with radiotherapy with curative int

AIM: Our aim was to investigate the effects of timing of cord clamping on the risk of hyperbilirubinaemia.METHODS: We recruited 540 normal vaginal deliveries at the Paropakar Maternity and Women's Hospital in Kathmandu, Nepal, from 2 October to 21 November 2014. They were randomised into two groups: 257/270 were cord clamped within 60 seconds and 209/270 after 180 seconds. Transcutaneous bilirubin

We studied the exclusive reaction e→pe′p′φ using the →φK+K− decay mode. The data were collected using a 4.2 GeV incident electron beam and the CEBAF Large Acceptance Spectrometer (CLAS) at the Thomas Jefferson National Accelerator Facility. Our experiment covers the range in Q2 from 0.7 to 2.2 GeV2, and W from 2.0 to 2.6 GeV. Taken together with all previous data, we find a consistent picture of φ

Background: Clostridium acetobutylicum is an anaerobic bacterium which is known for its solvent-producing capabilities, namely regarding the bulk chemicals acetone and butanol, the latter being a highly efficient biofuel. For butanol production by C. acetobutylicum to be optimized and exploited on an industrial scale, the effect of pH-induced gene regulation on solvent production by C. acetobutyli

In this chapter we explore the temporal dynamics of using forest bioenergy to mitigate climate change. We consider such issues as: growth dynamics of forests under different management regimes; the substitution effects of different bioenergy and biomaterial uses; temporary carbon storage in harvested biomass; the availability of different biomass fractions at different points of a wood product lif

Numerical analysis have been performed on tensile test experiment data to evaluated the performances of a 9 microns thick aluminium foil. The identification of the anisotropic material properties is based on tensile tests performed in 11 di↵erent angles from 0 to 90 from the rolling direction. By least square fitting and extrapolation to zero load the elastic modulus is, as opposed to the general Numerical analysis have been performed on tensile test experiment data toevaluated the performances of a 9 microns thick aluminium foil. The identification of theanisotropic material properties is based on tensile tests performed in 11 different anglesfrom 0◦to 90◦from the rolling direction. By least square fitting and extrapolation tozero load the elastic modulus is, as opposed to the general bel

Primary prevention of type 1 diabetes (T1D) requires intervention in genetically at-risk infants. The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) has established a screening program, GPPAD-02, that identifies infants with a genetic high risk of T1D, enrolls these into primary prevention trials, and follows the children for beta-cell autoantibodies and diabetes. Genetic testin