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Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface

Lubricin, a heavily O-glycosylated protein, is essential for boundary lubrication of articular cartilage. Strong surface adherence of lubricin is required given the extreme force it must withstand. Disulfide bound complexes of lubricin and cartilage oligomeric matrix protein (COMP) have recently been identified in arthritic synovial fluid suggesting they may be lost from the cartilage surface in o

Non-coding RNAs in beta cell insulin secretion - emerging players in Type 2 Diabetes pathogenesis

Type 2 diabetes (T2D) is a complex polygenic disease influenced by both environmental and genetic factors resulting in impaired insulin release from pancreatic beta cells and insulin resistance in target tissues. The incidence of T2D is escalating and it is projected that over 640 million people will be affected by 2040. Therefore, it is imperative to understand molecular processes that cause T2D

TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

Recent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (LUAD), where its role and mechanism of action remain unknown. We have previously established that the membrane receptor FGFR2 drives LUAD progression through aberrant protein-protein interactions mediated via its C-terminal proline-rich motif. Here we report that the N-terminal ankyrin repeats of TRPA1 direct

Multiplicity dependence of identified particle production in proton-proton collisions with ALICE

The study of identified particle production as a function of transverse momentum (pT) and event multiplicity in proton-proton (pp) collisions at different center-of-mass energies (s) is a key tool for understanding similarities and differences between small and large collisions systems. We report on the production of π±, K±, KS 0, p(p‾), Λ(Λ‾), Ξ± and Ω± measured in pp collisions in a wide range o

Setting Limits in Nature and the Metabolism of Knowledge: The Case of the Critical Load Concept

In the 1980s, the earlier understanding that environmental problems are relatively simple was questioned. In order to handle the perceived complexity, several responses emerged. The Critical Load concept is a prominent example of such a response, which was introduced in thesecond-generation Protocols of the Convention of Long Range Transport of Air Pollutants (CLRTAP). The aim of this thesis is to

Cosmopolitan militaries and dialogic peacekeeping : Danish and Swedish women soldiers in Afghanistan

Feminist security studies (FFS) scholarship advocates the analysis of women’s war experiences and narratives to understand conflict and military intervention. Here we add a non-great power focus to FFS debates on the gendered discourses of military interventionism. We zoom in on Danish and Swedish women soldiers’ reflections on their involvement in the ISAF operation in Afghanistan. Their stories

Coupling stochastic EM and approximate Bayesian computation for parameter inference in state-space models

We study the class of state-space models and perform maximum likelihood estimation for the model parameters. We consider a stochastic approximation expectation–maximization (SAEM) algorithm to maximize the likelihood function with the novelty of using approximate Bayesian computation (ABC) within SAEM. The task is to provide each iteration of SAEM with a filtered state of the system, and this is a

Capturing nanoscale effects by peridynamics

Molecular dynamic simulations inevitably demand large computational resources for structures of liner measures even as small as a few tens or hundreds of nanometers. Thus, a computationally efficient method to simulate larger structures and, at the same time, retain the properties and the mechanical response at the atomic scale is in demand. One such approach is peridynamics, which is a nonlocal e

Prediction of binding poses to FXR using multi-targeted docking combined with molecular dynamics and enhanced sampling

Advanced molecular docking methods often aim at capturing the flexibility of the protein upon binding to the ligand. In this study, we investigate whether instead a simple rigid docking method can be applied, if combined with multiple target structures to model the backbone flexibility and molecular dynamics simulations to model the sidechain and ligand flexibility. The methods are tested for the

Enhanced Size Selection in Two-Photon Excitation for CsPbBr3 Perovskite Nanocrystals

Cesium lead bromide (CsPbBr3) perovskite nanocrystals (NCs), with large two-photon absorption (TPA) cross-section and bright photoluminescence (PL), have been demonstrated as stable two-photon-pumped lasing medium. With two-photon excitation, red-shifted PL spectrum and increased PL lifetime is observed compared with one-photon excitation. We have investigated the origin of such difference using t

In Situ Synchrotron X-ray Diffraction Analysis of the Setting Process of Brushite Cement : Reaction and Crystal Growth

Brushite cements are fast self-setting materials that can be used as bone substitute materials. Although tracing their fast setting process is a challenge, it is important for the understanding of the same, which in turn is important for the material's further development and use in the clinics. In this study, the setting rate, phase formation, and crystal growth of brushite cements were quantitat

Post-colonial governance through securitization? : A narratological analysis of a securitization controversy in contemporary Danish and Greenlandic uranium policy

The complex constitutional relationship between Greenland and Denmark has had no clearer manifestation than the last decade’s juridical and political wranglings over the control for uranium. In the article, we argue that the quarrel between Nuuk and Copenhagen found in their diverging uranium policies can be seen as what we term a ’securitization controversy’. That is, a form of negotiating proces

How participatory can participatory modeling be? Degrees of influence of stakeholder and expert perspectives in six dimensions of participatory modeling

The authors are involved in a project aiming at the development of a methodology for participatory modeling as a tool for public participation in water resource management. In this paper, some examples of different degrees of stakeholder influence in six key dimensions of participatory modeling are identified and discussed. Arnstein's (A ladder of citizen participation. Journal of the American Ins

Accumulation effects in modulation spectroscopy with high-repetition-rate pulses : Recursive solution of optical Bloch equations

Application of the phase-modulated pulsed light for advance spectroscopic measurements is the area of growing interest. The phase modulation of the light causes modulation of the signal. Separation of the spectral components of the modulations allows to distinguish the contributions of various interaction pathways. The lasers with high repetition rate used in such experiments can lead to appearanc

Economic Downturns and Political Competition Since the 1870s

Relying on new data on the ideology of heads of government in 27 democracies over a period of more than 140 years, this article shows that short economic downturns, with a single year of falling per capita consumption, have more often resulted in shifts to the right than shifts to the left. But long-lasting economic downturns, with more than one consecutive year of falling consumption, are differe

Using catchment models to establish measure plans according to the Water Framework Directive

A participatory modelling process (DEMO) has been developed and applied in a 350 km(2) catchment in southern Sweden. The overall goal is to improve the dialogues between experts and local stakeholders by using numerical models as a platform for discussions. The study is focused on reducing nutrient load and on the development of a locally established measure plan, which is requested by the Europea