Bone-metastatic, castration-resistant prostate cancer (bmCRPC) represents a lethal stage of the most common noncutaneous cancer in men. The recent introduction of Radium-223 dichloride, a bone-seeking alpha particle (α)-emitting radiopharmaceutical, demonstrates statistically significant survival benefit and palliative effect for bmCRPC patients. Clinical results have established safety and effica

BACKGROUND: Cannabinoid receptor (CB)-mediated functions may be involved in the regulation of bladder function, but information on endocannabinoid signals during micturition is scarce. OBJECTIVE: Investigate the expression of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) in human, rat, and mouse bladders and study the effects of inhibition of FAAH during urodynamics in awa

Synthetic peptides derived from the sequence surrounding tyrosine-857 in the human platelet-derived growth factor (PDGF) beta-receptor were used to elucidate the requirement for length and presence of negative and positively charged amino acids in substrates of the PDGF beta-receptor protein tyrosine kinase. The measured Km for the different peptides were all in the range 1-10 mM. A peptide of onl

An introduction to high-power lasers and strong-field laser-atom interactions is given, and the main experimental and theoretical results concerning high-order harmonic generation are reviewed. The single atom response as well as the macroscopic phase-matching effect is discussed. The formation and extent of the characteristic plateau in the harmonic spectra are discussed in terms of a physical pi

Endometrial stromal sarcomas (ESS) are rare malignancies, accounting for less than 10% of uterine sarcomas. Apart from the chromosomal rearrangement t(7;17)(p15;q21), which leads to the JAZF1/SUZ12 chimera, cytogenetic studies have shown that the chromosome band 6p21 is often rearranged in ESS. The translocation partners involved in the 6p21 rearrangements differ among the tumors, but chromosome 7

This doctoral dissertation is an overview of the recently arisen Sango language spoken in the Central African Republic. The overview contains a sociolinguistic and linguistic dimension with a lexical-semantic focus. The study is set within a multidisciplinary framework including a functional-typological perspective, language change induced by contact, and language planning. The study shows that th

Local factors influencing the rate of diffusion of residential photovoltaic (PV) systems are insufficiently understood. This multiple-case study explored five Swedish municipalities which have had a particularly high PV density in terms of number of installations per capita, compared to other municipalities. The aim was to identify and assess local factors that could explain these relatively high

Windmills, but no flour: A reply on Stefan Larssons comments on my article, "Flugten fra middelalderen" (The escape from the Middle Ages) in META 1999: 1

Det finns i vår kultur en djupt rotad föreställning om att det danar karaktären och är bra för disciplinen att gå upp tidigt på morgonen. I industri­samhället, där äldre barn och ungdomar var en ­vital del av arbetskraften, var tidiga morgnar ofta en nödvändighet för att dagsljuset skulle kunna användas maximalt även den mörka tiden på året. Detta förhållningssätt till klocktiden har levt kvar änd

Sveriges väg till medlemskap i Bretton Woods-organisationerna (Valutafonden och Världsbanken) har hittills i det närmaste legat försänkt i historisk skugga. Den vägen sträcker sig från 1943, när de allierade valutaplanerna för efterkrigstiden presenterades, och fram till 1951, när Sverige gick med i det internationella valutasamarbetet. I den här artikeln beskrivs de viktigaste händelserna, aktöre