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Single-laser shot fluorescence lifetime imaging on the nanosecond timescale using a Dual Image and Modeling Evaluation algorithm

A novel technique, designated dual imaging and modeling evaluation (DIME), for evaluating single-laser shot fluorescence lifetimes is presented. The technique is experimentally verified in a generic gas mixing experiment to provide a clear demonstration of the rapidness and sensitivity of the detector scheme. Single-laser shot fluorescence lifetimes of roughly 800 ps with a standard deviation of s

Rho-GTPases in Morphogenesis and Differentiation of the Developing Pancreas

Branched tubular networks constitute the basic structure of many organs to increase surface area and to transport fluids and gases. Glandular organs such as the pancreas arise from multilayered epithelium, which undergoes de novo lumen formation and extensive remodeling and branching. Endocrine cells originate from endocrine progenitors within the ductal epithelium. Upon differentiation into hormo

The social complexity of renewable energy production in the countryside

Based on field studies in 7 cases rural renewable energy projects in Brandenburg (federal state of Germany) were analysed during an 18 month period (early 2009 to mid 2010). The study identified relevant social dimensions of renewable energy technology and classified them according to organizational complexity, technology acceptance, participation by locals and financing models. This research show

Combined membrane filtration and enzymatic treatment for recovery of high molecular mass hemicelluloses from chemithermomechanical pulp process water

Hemicelluloses with high molecular mass are needed for the manufacture of value added products such as food packaging barrier films. In this work such molecules were recovered from chemithermomechanical pulp (CTMP) process water using an innovative three-stage process comprising membrane separation and enzymatic treatment with laccase. Microfiltration followed by ultrafiltration was found to be a

Superoxide dismutase inspired immobilised Ni(II)-protected amino acid catalysts Synthesis, characterisation, and catalytic activity

Covalently anchored Ni(II)-C-protected amino acid (L-histidine, L-cysteine, and L-cystine) complexes inspired by the active site of the Ni-superoxide dismutase enzyme were synthesised using chloropropylated silica gel as support. The structural features of the surface complexes were studied by the Kjeldahl method and ICP-MS, mid/far IR, UV-vis diffuse reflectance, and X-ray absorption spectroscopi

Kontraster och nyanser. Svensk statsvetenskap i brytningstid.

Statsvetenskapliga förbundet fyller 40 år och det uppmärksammas med en skrift där svenska och nordiska samhällsforskare i ett drygt fyrtiotal uppsatser redovisar sin syn på svensk statsvetenskap. Några gör det genom personliga bildningsresor, andra försöker fånga de långa linjerna i en specialitets utveckling eller tar spjärn mot etablerade traditioner. Några skribenter argumenterar för nya empiri

Adsorption of α-Synuclein to Supported Lipid Bilayers: Positioning and Role of Electrostatics.

An amyloid form of the protein α-synuclein is the major component of the intraneuronal inclusions called Lewy bodies, which are the neuropathological hallmark of Parkinson's disease (PD). α-Synuclein is known to associate with anionic lipid membranes, and interactions between aggregating α-synuclein and cellular membranes are thought to be important for PD pathology. We have studied the molecular

Developing General Practice: The Role of the APO method

Abstract General practice is a broad and multifaceted field of knowledge. Political steering instruments declare that general practice and primary care are characterized by a holistic perspective on the individual, with quality, accessibility, continuity, and cooperation being important factors. For the last few decades, quality assurance has been in focus in Swedish health care. Inspiration has c

Integrating fluvial processes into the global Si cycle

Popular Abstract in Swedish Kisel (Si) förekommer i alla naturliga vatten i form av löst kisel och är ett näringsämne för många växt- och djurarter. Löst kisel kommer ursprungligen från kiselhaltiga mineral som har vittrat. Vid vittringen går det åt koldioxid (CO2) och på så vis finns det ett samband mellan omsättningen av kisel och kol. Både upptag och vittring av kisel bidrar till att fördelningSilicon (Si) is ubiqutious in natural waters as dissolved silica (DSi) and is used as a nutrient by many plant and animal species. DSi ultimately derives from the weathering of silicate minerals, a process which also consumes atmospheric CO2 and couples the silicon and carbon cycles. These processes, among others, impart observable fractionations to the stable isotopes of silicon, which makes the

The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation

Background: The neural transcription factor SOX11 has been described as a prognostic marker in epithelial ovarian cancers (EOC), however its role in individual histological subtypes and tumour grade requires further clarification. Furthermore, methylation-dependent silencing of SOX11 has been reported for B cell lymphomas and indicates that epigenetic drugs may be used to re-express this tumour su

Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome - a randomized study.

Few studies have explored the possible plasma cholesterol lowering effects of rye consumption. The aim of this secondary analysis in the SYSDIET study was to investigate the association between plasma alkylresorcinols (AR), a biomarker for whole grain wheat and rye intake, and blood lipid concentrations in a population with metabolic syndrome. Furthermore, we analyzed the associations between the

The role of the law enforcement agencies in transport security, a survey with Swedish operators

Transport security, that is, the protection against antagonistic attacks in form of terrorism, theft, counterfeiting, piracy etc. has become a major concern for managers during the last years. The consequences of security incidents include economic losses for industries, but in case of terror attacks may also affect society in general. If transport networks are not adequately protected, consumable

The COST 2100 MIMO Channel Model

The COST 2100 channel model is a geometry-based stochastic channel model (GSCM) that can reproduce the stochastic properties of multi-link Multiple-Input Mulitple-Output (MIMO) channels over time, frequency and space. By contrast to other popular GSCMs, the COST 2100 approach is generic and flexible, making it suitable to model multi-user or distributed MIMO scenarios. In this paper a concise over

Hard X-ray Detection Using a Single nm Diameter Nanowire

Submicron sized sensors could allow higher resolution in X-ray imaging and diffraction measurements, which are ubiquitous for materials science and medicine. We present electrical measurements of a single 100 nm diameter InP nanowire transistor exposed to hard X-rays. The X-ray induced conductance is over 5 orders of magnitude larger than expected from reported data for X-ray absorption and carrie

A proposal that does not advance our understanding of hypnosis

In his paper Hypnosis Reconsidered, Resituated, and Redefined (JSE 26(2):297–327), Adam Crabtree, a distinguished expert in the history of hypnosis, maintains that contemporary hypnosis research suffers from conceptual disorder. In his words, he attempts to redefi ne hypnosis in order to provide a stronger ground for future research. We find that his proposed reconsideration of hypnosis as a form

Energy availability and the female athlete triad in elite endurance athletes

The female athlete triad (Triad), links low energy availability (EA), with menstrual dysfunction (MD), and impaired bone health. The aims of this study were to examine associations between EA/MD and energy metabolism and the prevalence of Triad-associated conditions in endurance athletes. Forty women [26.2 +/- 5.5 years, body mass index (BMI) 20.6 +/- 2.0 kg/m(2), body fat 20.0 +/- 3.0%], exercisi

Environmental assessment and scenario analysis of sugar beet transport in Scania, Sweden

The aim was to assess the environmental sustainability of sugar beet transport in Scania, Sweden—estimating lorry travel distances, fuel use and air emissions. Scenario analyses measuring the same parameters for switching to newer vehicle types and differing ratios of biodiesel were also performed. The method applied for distance calculations was a GIS-based proximity analysis. Results revealed th