Here, we describe a novel monoolein-based cubosome formulation engineered for possible theranostic applications in oncology. The Docetaxel-loaded nanoparticles were stabilized in water by a mixture of commercial Pluronic (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer) F108 (PF108) and rhodamine- and folate-conjugated PF108 so that the nanoparticles possess targ

Isolated islands and their often unique biota continue to play key roles for understanding the importance of drift, genetic variation, and adaptation in the process of population differentiation and speciation. One island system that has inspired and intrigued evolutionary biologists is the blue tit complex (Cyanistes spp.) in Europe and Africa, in particular the complex evolutionary history of th

Over the past years fast label-free nonlinear imaging modalities providing molecular contrast of endogenous disease markers with subcellular spatial resolution have been emerged. However, applications of these imaging modalities in clinical settings are still at the very beginning. This is because single nonlinear imaging modalities such as second-harmonic generation (SHG) and two-photon excited f

We present an algorithm that leads to BCJ numerators satisfying manifestly the three properties proposed by Broedel and Carrasco in [42]. We explicitly calculate the numerators at 4, 5 and 6-points and show that the relabeling property is generically satisfied.

Various samples of the solid solution Gd2NixCu2-xMg were synthesized from the elements in sealed tantalum ampoules in an induction furnace. All members crystallize with the tetragonal Mo2FeB2 type structure, space group P4/mbm, and they were characterized on the basis of Guinier powder patterns and energy dispersive X-rays analyses. The lattice parameters decrease with increasing nickel content in

In the field of biomedical X-ray imaging, novel techniques, such as phase-contrast and dark-field imaging, have the potential to enhance the contrast and provide complementary structural information about a specimen. In this paper, a first prototype of a preclinical X-ray phase-contrast CT scanner based on a Talbot-Lau interferometer is characterized. We present a study of the contrast-to-noise ra

Dwarf males (nannandry) occur in many unrelated, mostly aquatic, groups of organisms. Among land plants they are unique to bryophytes. In this study our aim was to explain variation in frequency of dwarf males and fertilization within populations in the moss Homalothecium lutescens. We compared parameters related to dwarf male presence and sporophyte production in 90 colonies from three localities

Mn-doped GaAs nanowires were grown in the self-catalytic growth mode on the oxidized Si(100) surface by molecular beam epitaxy and characterized by scanning and transmission electron microscopy, Raman scattering, photoluminescence, cathodoluminescence, and electron transport measurements. The transmission electron microscopy studies evidenced the substantial accumulation of Mn inside the catalyzin

Long-chain n-6 and n-3 PUFA (LC-PUFA), arachidonic acid (AA) (20:4n-6) and DHA (22:6n-3), are critical for optimal brain development. These fatty acids can be consumed directly from the diet, or synthesized endogenously from precursor PUFA by Δ-5 (encoded by FADS1) and Δ-6 desaturases (encoded by FADS2). The aim of this study was to determine the potential importance of maternal genetic variabilit

Objective: The Intermittent and Constant Osteoarthritis (OA) Pain (ICOAP) questionnaire evaluates the constructs of 'intermittent' and 'constant' pain. Theses are conceptually different from 'pain on activity' and pain 'intensity' as measured by the WOMAC and Chronic Pain Grade (CPG), measures commonly used in OA. The purpose of this study was to evaluate the responsiveness of the ICOAP, and diffe

The anaesthetic conserving device AnaConDa(®) (ACD) reflects exhaled anaesthetic agents thereby facilitating the use of inhaled anaesthetic agents outside operating theatres. Expired CO2 is, however, also reflected causing a dead space effect in excess of the ACD internal volume. CO2 reflection from the ACD is attenuated by humidity. This study tests the hypothesis that sevoflurane further attenua

To promote a healthy and active lifestyle there is a need to increase our knowledge of the level of physical activity (PA) among people with late effects of polio.

Integrated cross-sectoral impact assessments facilitate a comprehensive understanding of interdependencies and potential synergies, conflicts, and trade-offs between sectors under changing conditions. This paper presents a sensitivity analysis of a European integrated assessment model, the CLIMSAVE integrated assessment platform (IAP). The IAP incorporates important cross-sectoral linkages between

In initiating the development of a large-scale golf resort in Aberdeenshire, Trump International Golf Links Scotland made a relatively unknown site central to Scottish planning debates. A stretch of land along the North Sea coast north of Aberdeen became linked to new possible futures. Part of the site developed consisted of moving sand dunes given environmental protection as a Site of Special Sci

Neuron-specific enolase (NSE) is a widely-used biomarker for prognostication of neurological outcome after cardiac arrest, but the relevance of recommended cutoff values has been questioned due to the lack of a standardized methodology and uncertainties over the influence of temperature management.

BACKGROUND: Heart or lung recipients are taught about a new lifestyle, risk factors, medication, food restrictions and exercise so they can take an active role and responsibility for disease management after transplantation. However, little is known about patients' experiences of information and support in these situations. OBJECTIVE: The aim of the study was to illuminate how patients, six months

To evaluate the psychometric properties of a questionnaire addressing psychosocial consequences of false-positive mammographic screening.