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Quadrupole moments of collective structures up to spin similar to 65(h)over-bar in Er-157 and Er-158: A challenge for understanding triaxiality in nuclei

The transition quadrupole moments. Q(t), of four weakly populated collective bands up to spin similar to 65h in Er-157,Er-158 have been measured to be similar to II eb demonstrating that these sequences are associated with large deformations. However, the data are inconsistent with calculated values from cranked Nilsson-Strutinsky calculations that predict the lowest energy triaxial shape to be as

Comparison of geoelectrical imaging and tunnel documentation at the Hallandsas Tunnel, Sweden

For construction in rock a thorough pre-investigation is important in order to avoid unforeseen conditions which may delay the work. It is crucial to remember the results from this investigation in the further work, and use the experience from the construction to update the geological prognosis and reduce the uncertainties. Different geophysical methods have proved valuable tools in such investiga

Contextual inquiry and socio-technical practice

Purpose: During discussions at the ASC 2013 Conference, we were stimulated to consider acting,learning and understanding in the context of organizational change, and in particular the relationship between organizational actors and external analysts. This article therefore seeks to review from a cybernetic perspective how a socio-technical toolbox can help to facilitate organisational change, and t

A snapshot into the terrestrial ecosystem of an exceptionally well-preserved dinosaur (Hadrosauridae) from the Upper Cretaceous of North Dakota, USA

A palynological investigation of sedimentary rocks enclosing an exceptionally well-preserved fossil dinosaur (Hadrosauridae) discovered in the upper part of the Hell Creek Formation in south western North Dakota was conducted in order to document the immediate paleoenvironment of this dinosaur. The specimen, an Edmontosaurus annectens is remarkable in having exceptional three-dimensional preservat

Joint Bayesian Positioning and Multipath Mitigation in GNSS

A sequential Bayesian estimation algorithm for joint positioning and multipath mitigation within satellite navigation receivers is presented. The underlying process model is especially designed for dynamic user scenarios and dynamic channel conditions. To demonstrate its capabilities simulation results are presented.

Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy

The complexity of the central nervous system and existence of the blood-brain barrier often causes difficulties for traditional pharmacological treatments of neurological diseases. This thesis explores the feasibility and potential for novel gene and cell therapy approaches, which hold better promise for neurological disorders, while particularly targeting epilepsy. Epilepsy is a multifactorial ne

An urn model for odds ratio based adaptive phase III clinical trials

We study the limiting behaviour of a generalized Polya urn, motivated by adaptive data-dependent allocation designs, which are used in Phase III clinical trials in order to allocate a larger number of patients to the better treatment. We establish rigorous limiting results for the model, including the Central Limit Theorem, thus providing the theoretical background for using the odds ratio-based a

The management of iron deficiency in inflammatory bowel disease - an online tool developed by the RAND/UCLA appropriateness method

BackgroundIron deficiency is a common and undertreated problem in inflammatory bowel disease (IBD). AimTo develop an online tool to support treatment choice at the patient-specific level. MethodsUsing the RAND/UCLA Appropriateness Method (RUAM), a European expert panel assessed the appropriateness of treatment regimens for a variety of clinical scenarios in patients with non-anaemic iron deficienc

Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study

Background Interleukin (IL)-15 levels are increased in serum, synovium and bone marrow of patients with rheumatoid arthritis (RA). IL-15 influences both the innate and the adaptive immune response; its major role is activation and proliferation of T cells. There are also emerging data that IL-15 affects osteoclastogenesis. The authors investigated the association of genetic variants in IL15 with t

The 2010 global proficiency study of Human Papillomavirus genotyping in vaccinology.

Accurate and internationally comparable Human Papillomavirus (HPV) DNA genotyping is essential both for evaluation of HPV vaccines and for effective monitoring and implementation of vaccination programs. World Health Organisation (WHO) HPV Laboratory Network (LabNet) regularly issues international proficiency studies. The 2010 HPV genotyping proficiency panel for HPV vaccinology contained 43 coded

Association of a multibiomarker disease activity score at multiple time-points with radiographic progression in rheumatoid arthritis: results from the SWEFOT trial.

In rheumatoid arthritis (RA), predictive biomarkers for subsequent radiographic progression (RP) could improve therapeutic choices for individual patients. We previously showed that the multibiomarker disease activity (MBDA) score in patients with newly diagnosed RA identified patients at risk for RP. We evaluated the MBDA score at multiple time-points as a predictor of RP during 2 years of follow

Low PIP4K2B Expression in Human Breast Tumors Correlates with Reduced Patient Survival: A Role for PIP4K2B in the Regulation of E-Cadherin Expression

Phosphatidylinositol-5-phosphate (PtdIns5P) 4-kinase beta (PIP4K2B) directly regulates the levels of two important phosphoinositide second messengers, PtdIns5P and phosphatidylinositol-(4,5)-bisphosphate [PtdIns(4,5)P-2]. PIP4K2B has been linked to the regulation of gene transcription, to TP53 and AKT activation, and to the regulation of cellular reactive oxygen accumulation. However, its role in

Rapid and direct determination of fructose in food: A new osmium-polymer mediated biosensor

This paper describes the development and performance of a new rapid amperometric biosensor for fructose monitoring in food analysis. The biosensor is based on the activity of fructose dehydrogenase (FDH) immobilised into a carbon nanotube paste electrode according to two different procedures. The direct wiring of the FDH in a highly original osmium-polymer hydrogel was found to offer a better enzy

Molecular damage in bi-isonicotinic acid adsorbed on rutile TiO2(110)

Here we present the characteristic signatures in X-ray absorption and photoemission spectroscopy for molecular damage in adsorbed monolayers of bi-isonicotinic acid on a rutile TiO2(110) surface. Bi-isonicotinic acid is the anchor ligand through which many important inorganic complexes are bound to the surface of TiO2 in dye-sensitized solar cells. The nature of the damage caused by excessive heat

The Strange Case of Dr. Bucaille: Notes for a Re-examination

The present essay focuses on the figure of Maurice Bucaille and on his contribution to the discourse on Islam and science. Its purpose is twofold. First of all, it aims to provide the reader with a concise map of the ideas of the French author, reconstructing their core and their interrelations. Furthermore, it aims to question what I define as the apparent naivety of Bucaille's work, a reason why

Additive-induced morphological tuning of self-assembled silica-barium carbonate crystal aggregates

Crystallisation of barium carbonate from alkaline silica solutions results in the formation of extraordinary micron-scale architectures exhibiting non-crystallographic curved shapes, such as helical filaments and worm-like braids. These so-called "silica biomorphs" consist of a textured assembly of uniform elongated witherite nanocrystallites, which is occasionally sheathed by a skin of amorphous