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FLT3 is a critical prognostic marker in acute myeloid leukemia (AML) due to its high frequency of mutation. Primary mutations in FLT3 include point mutations or deletions in the tyrosine kinase domain (TKD) and internal tandem duplications (ITD) in the juxtamembrane (JM) region. These mutations lead to ligand-independent activation, disrupting the JM region and kinase domain interaction, resulting

Partnervåld utgör ett allvarligt samhällsproblem med omfattande konsekvenser för både individer och samhälle. För att minska risken för skada till följd av problemet behöver socialtjänsten arbeta med både primär och sekundär prevention. Ett effektivt förebyggande arbete förutsätter emellertid kunskap om den tidsmässiga ordningen och variationen av riskfaktorer som är förknippade med utövande av paIntimate partner violence (IPV) is a serious social issue with profound consequences for individuals and society. To reduce the risk of harm caused by IPV perpetration, social services need to engage in both primary and secondary prevention efforts targeting the issue. However, effective preventive work requires knowledge about the temporal sequence and variability of risk factors associated with

Purpose: The study examines how CEOs' and founders' social and political declarations influence Generation Z's conditional brand loyalty in an era in which personal and corporate identity are more intertwined than ever. Focusing on how leaders' public stands on controversial topics—in particular the Israel-Palestine conflict—determine consumer trust, the research aims to establish

Purpose: To examine how a new product category, namely white snus, emerges and is positioned within the tobacco-free nicotine market. The research uses VELO’s evolution from EPOK, to LYFT to VELO as the case study. Methodology: Literature review, qualitative and inductive approach, primary and secondary sources Findings: White snus shifts “traditional tobacco” to “clean/white” through a sequence

Purpose: This study aims to analyse how the founder as brand concept can affect Customer Based Brand Equity. The research aims to contribute insights on how founder representation can strengthen or weaken brand perception among consumers. Methodology: This research follows a quantitative, abductive design. Primary data were collected through a semi-structured focus group interview and secondary da

Purpose: The purpose of this paper is to examine how the personal stories and narratives attached to the Hermès Birkin bag intersect with the brand’s corporate storytelling to shape reputation and reveal a possible reversal of the Brand Identity Matrix. Design/methodology/approach: Qualitative research was conducted, using the case of Hermès and the Birkin bag. Secondary data was collected from o

Purpose: To investigate how revealing the official secrets in different industries influence consumer trust. Methodology: Primary data were collected through a quantitative consumer survey measuring the impact of revealing an official secret on trust. This was complemented by secondary case analyses of Polestar and Kérastase, supported by relevant literature and industry sources to contextualize

This study presents the fabrication of all-dielectric silicon-based twisted L-shape metamaterials using a two-step electron-beam glancing angle deposition approach. Systematic chiroptical characterization and optimization are performed through Mueller matrix generalized spectroscopic ellipsometry and finite element modeling, demonstrating tunable, broadband chirality response with potential applic

Data-driven modeling frameworks have become essential tools for guiding surveillance strategies and informing public health policies across diverse population health challenges. Accurate, fine-scale disease estimates often lacking from direct surveys are critical for policy planning, given that spatial heterogeneity and nonlinear dynamics among determinants of health challenge classical models, li

Trust is a prerequisite for successful learning.From previous work we know that teachers use multiplestrategies to build trust with students – for example todemonstrate knowledge, skill and competence, or showinginterpersonal care and concern. We also know from studentsthat they trust teachers who ask, listen, and respond. But sincewe conducted those studies, Generative Artificial Intelligence(Gen

Bridge monitoring is essential for ensuring their long-term safety, reducing disruptions, and supporting economic and social activities. Traditional monitoring techniques rely on periodic inspections and contact-based sensing systems, which, while effective, have limitations due especially to high installation and maintenance costs. Satellite-based Synthetic Aperture Radar Interferometry (InSAR) o

Background. Post-traumatic chondral and osteochondral lesions can be treated with autologous chondrocyte implantation (ACI), but the high cost of autologous cell expansion under strict Good Manufacturing Practice (GMP) regulations limits patient access. Stem cell–based advanced therapy medicinal products (ATMPs) offer more cost-effective alternatives, with human induced pluripotent stem cells (iPS

The research evaluated retrofitting options for a threestory church community building in Grevie, Sweden, assessing the impacts on energy efficiency, life cycle cost, and environmental concerns. An energy model was generated in IDA ICE to simulate the building performance. Various improvements were tested in two separate retrofit package scenarios. They had the following measures in common: the ad

Transport has a large impact on children’s lives from facilitating or limiting their mobility and access to destinations to impacting their health and wellbeing. However, cities have primarily focused on facilitating motor vehicle travel, which is an adult-exclusive mode. Likely, as a result, many children are escorted to places. In this chapter, we summarize literature on children’s travel from a

Aging is the primary risk factor for most neurodegenerative diseases, yet the cell-type-specific progression of brain aging remains poorly understood. Here, human cell-type-specific transcriptomic aging clocks are developed using high-quality single-nucleus RNA sequencing data from post mortem human prefrontal cortex tissue of 31 donors aged 18–94 years, encompassing 73,941 high-quality nuclei. Di

Tuning the spectral and directional characteristics of thermal emission is critical for advancing technologies such as thermophotovoltaics (TPVs), passive thermal radiative cooling (PTRC), and solar thermophotovoltaics (STPVs), yet scalable fabrication methods remain limited. Here, femtosecond laser surface processing (FLSP), a top-down ablation and re-solidification approach is employed, to creat

BACKGROUND: Respiratory viruses, such as influenza viruses and SARS-CoV-2, cause severe infections of the respiratory system. Cohort studies and clinical observations indicate that patients with severe influenza A virus (IAV) infections are at an increased risk of developing an ischemic stroke event. However, the underlying mechanisms remain elusive. To this end, we investigated the consequences o