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Rye-based evening meals favorably affected glucose regulation and appetite variables at the following breakfast; a randomized controlled study in healthy subjects

Background Whole grain has shown potential to prevent obesity, cardiovascular disease and type 2 diabetes. Possible mechanism could be related to colonic fermentation of specific indigestible carbohydrates, i.e. dietary fiber (DF). The aim of this study was to investigate effects on cardiometabolic risk factors and appetite regulation the next day when ingesting rye kernel bread rich in DF as an e

TNF-induced superoxide anion production in adherent human neutrophils involves both the p55 and p75 TNF receptor

TNF, a potent activator of neutrophil granulocytes, acts via two cell-surface receptors: the p55-TNF receptor (TNF-R55) and the p75-TNF receptor (TNF-R75), which can be cleaved from the cell surface and thus form soluble TNF-binding proteins (TNF-BP). The role of the two receptors in activation of the neutrophil respiratory burst was investigated. Two mAbs reacting with TNF-R55 (H398 and TBP2) ind

Transactivation of EGF receptors in chicken Müller cells by α2A-adrenergic receptors stimulated by brimonidine

PURPOSE: Alpha2-adrenergic receptor agonists are used in glaucoma treatment and have been shown to have some neuroprotective effects. We performed this study to test the hypothesis that epidermal growth factor receptors on chicken Müller cells are transactivated by α2-adrenergic receptors and we focused on the extracellular signal-activated kinases 1/2 (ERK) pathway.METHODS: Embryonic chicken reti

Differential molecular and behavioural response to L-DOPA in mice injected with 6-hydroxydopamine in the striatum or in the medial forebrain bundle

Unilateral lesions of nigrostriatal dopamine ( DA) pathways with 6-hydroxydopamine (6-OHDA) can be used to obtain a model of Parkinson's disease in the mouse. In the present study we examine two types of unilateral 6-OHDA lesions in the mouse for their ability to induce stable motor deficits and supersensitive molecular and behavioural response to L-DOPA.

Expression of the chemokine CXCL14 in the tumour stroma is an independent marker of survival in breast cancer

Background:Expression of the chemokine CXCL14 has previously been shown to be elevated in the tumour stroma of, for example, prostate and breast cancer. Cancer-associated fibroblast-derived CXCL14 enhances tumour growth in mouse models of prostate and breast cancer. However, the prognostic significance of compartment-specific expression of CXCL14 has not been studied.Methods:CXCL14 mRNA expression

The temporal relationship between poor lung function and the risk of diabetes

Background: The association between impaired lung function and diabetes risk has been established in the past, however the temporal and causal relationships between the two remain unclear. We assessed the relationship between baseline FEV1 and FVC and risk of incident diabetes at different time intervals for participants in the Malmö Preventive Project cohort. Methods: Baseline lung function was a

“We are not in this to save the polar bears!” : the link between community renewable energy development and ecological citizenship

The transition from a fossil fuel-based energy system to a renewable one has emerged as a priority for many governments. This, in turn, has facilitated a rapid increase in renewable energy investments. However, this development raises important questions about the sustainability of energy governance when it comes to access and control of energy, public participation and transparency. In this artic

Occupations, perceived stress, and stress-related disorders among women and men in the public sector in Sweden

Background: Stress-related disorders are a public health problem and represent a significant burden to individuals and society. It is, therefore, of importance to regard stress in a wider context and identify risk factors not only at work but in all occupations in everyday life, to prevent ill health. Aim/objective: The aim of this study was to examine potential associations between everyday occup

Fast Radon Transforms and Reconstruction Techniques in Seismology

The measurements conducted in tomography and seismology typically yield large multidimensional data sets. This in combination with the fact that the data may have an irregular structure makes it computationally prohibitive to use simple reconstruction methods directly. Hence, for inverse problems in computed tomography and seismology there is a demand for fast computational methods using high-perf

Quantitative studies of animal colour constancy: using the chicken as model

Colour constancy is the capacity of visual systems to keep colour perceptionconstant despite changes in the illumination spectrum. Colour constancy hasbeen tested extensively in humans and has also been described in manyanimals. In humans, colour constancy is often studied quantitatively, butbesides humans, this has only been done for the goldfish and the honeybee.In this study, we quantified colo

Brogård backwards: The high-end golf landscape, and the morphology of manorial space

When Bro Hof Slott Golf Club – a high-end, highprofile golf development in Upplands-Bro, northwest of Stockholm – opened, the Brogård manor house became its clubhouse. Here a recent history of Bro Hof Slott as leisure space intermingles with a much longer history of Brogård as a landscape shaped through 400 years of nobility ownership. In place-marketing and in short accounts, the estate's history

How competitive forces sustain electric vehicle development

This patent study researches the relation between competitive forces and the continuation of waves of Low Emission Vehicle (LEV) development. The competitive forces included are rivalry, dispersion referring to competition in general, and the presence of new entrants. We identify four waves of LEV development over the period 1990-2010, two of which were broken before becoming a commercial success,