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Engaging the missing actor : lessons learned from an age-management intervention targeting line managers and their HR partners

Purpose – This study aims to describe and evaluate the impact of a participatory age-management intervention on the knowledge, awareness and engagement of line managers and their HR partners from six health-care organizations in Sweden.Design/methodology/approach – The learning workshops consisted of lectures, discussions, feedback and exchange of experiences with colleagues and invited experts. A

The dynamic floor of Yellowstone Lake, Wyoming, USA : The last 14 k.y. of hydrothermal explosions, venting, doming, and faulting

Hydrothermal explosions are significant potential hazards in Yellowstone National Park, Wyoming, USA. The northern Yellowstone Lake area hosts the three largest hydrothermal explosion craters known on Earth empowered by the highest heat flow values in Yellowstone and active seismicity and deformation. Geological and geochemical studies of eighteen sublacustrine cores provide the first detailed syn

Microstructure in SOFC: electrochemical simulations and experiments

Solid oxide fuel cells (SOFCs) are highly efficient and environmentally friendly power sources that convert chemical energy directly into electricity and heat, without the need for combustion. Despite their many benefits, the performance and durability of SOFCs heavily depend on the quality of their porous anode and cathode components. There are significant challenges with regard to their commerci

On the Challenges of Software Performance Optimization with Statistical Methods

Most recent programming languages, such as Java, Python and Ruby, include a collection framework as part of their standard library (or runtime). The Java Collection Framework provides a number of collection classes, some of which implement the same abstract data type, making them interchangeable. Developers can therefore choose between several functionally equivalent options. Since collections hav

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets

Clonal hematopoiesis of indeterminate potential (CHIP) is a common form of age-related somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations can be identified in peripheral blood samples that are sequenced using approaches that cover the whole genome, the whole exome, or targeted genetic regions; however, differentiating true CHIP mutations from sequencing a

Antenna System Design for 5G and Beyond – A Modal Approach

Antennas are one of the key components that empower a new generation of wireless technologies, such as 5G and new radar systems. It has been shown that antenna design strategies based on modal theories represent a powerful systematic approach to design practical antenna systems with high performance. In this thesis, several innovative multi-antenna systems are proposed for wireless applications in

Occupational value outcomes among people with mental health issues participating in activity-based interventions–The importance of internal and external factors

Background: Perceived occupational value is an important treatment outcome but is still relatively unexplored as a phenomenon. Aim: To evaluate whether the Balancing Everyday Life (BEL) intervention for people with mental health issues was effective compared to Standard Occupational Therapy (SOT) regarding improvement on three dimensions of occupational value (concrete, socio-symbolic and self-rew

Features and Bugs in Schnieder’s Theory of Properties

Although Benjamin Schnieder’s theory of the “ordinary conception” of properties successfully handles paradoxical properties—particularly, the property of non-self-instantiation—it fails to account for ordinary, non-pathological cases. The theory allows the inference of ‘a has the property of being F’ only given F(a) and the prior assertibility of ‘the property of being F can exist’. While this all

Obstructive sleep apnoea heterogeneity and cardiovascular disease

Obstructive sleep apnoea (OSA), characterized by recurrent periods of upper airway obstruction and intermittent hypoxaemia, is prevalent in patients with cardiovascular disease (CVD), and is therefore important to consider in the prevention and management of CVD. Observational studies indicate that OSA is a risk factor for incident hypertension, poorly controlled blood pressure, stroke, myocardial

CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease

Cerebrospinal fluid (CSF) amyloid-β peptide (Aβ)42/Aβ40 and the concentration of tau phosphorylated at site 181 (p-tau181) are well-established biomarkers of Alzheimer’s disease (AD). The present study used mass spectrometry to measure concentrations of nine phosphorylated and five nonphosphorylated tau species and phosphorylation occupancies (percentage phosphorylated/nonphosphorylated) at ten si

Peasant in a Bottle : Infrastructures of Containment for an Italian Wine Cooperative

On the market for quality wine, quality is generally defined by the liquid’s connection to a time, space, and person(s) of origin. This connection is achieved through material-discursive versions of terroir. While the consequences of this aesthetic regime have been well-studied, little attention has been given to the artefact through which the connection is enacted: the bottle. This paper, based o

Exact analysis of One-Warehouse-Multiple-Retailer inventory systems with quantity restricted deliveries

Joint consideration and coordination of inventory and shipment decisions is an important challenge in the quest for sustainable distribution systems. This paper addresses this issue by presenting a method for exact analysis of the inventory level distributions in a centralized One-Warehouse-Multiple-Retailer (OWMR) inventory system with quantity restricted deliveries from the warehouse. The system

The discontinuum of river networks : the importance of geomorphic boundaries

Context: Rivers are heterogeneous landscapes characterised by distinct patches separated by boundaries. The significance of tributaries as dominant geomorphic boundaries in determining the character of the river discontinuum is a prevailing, yet largely unscrutinised, paradigm of river science. Objectives: This study examines the spatial organisation and strength of geomorphic boundaries within th

Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer

Background: No targeted drugs are currently available against small cell lung cancer (SCLC). BCL-2 family members are involved in apoptosis regulation and represent therapeutic targets in many malignancies. Methods: Expression of BCL-2 family members in 27 SCLC cell lines representing all known four SCLC molecular subtypes was assessed by qPCR, Western blot and mass spectrometry-based proteomics.

Factors related to a successful professional development for specialist nurses in surgical care : a cross-sectional study

Background: A high level of competence among staff is necessary for providing patient-safe surgical care. Knowledge regarding what factors contribute to the professional development of specialist nurses in surgical care and why they choose to remain in the workplace despite high work requirements is needed. To investigate and describe the organizational and social work environment of specialist nu

Uncovering hidden abilities for participation in research through photo-elicitation interviews : a view on participatory research with people living in residential care facilities

Background: Participatory research has been described to improve the relevance of research findings for the society in terms of quality of healthcare services and other public benefits. Nevertheless, there is limited guidance on how to conduct participatory research, and especially in relation to persons living in residential care facilities. To make the voices of this group heard, we therefore ta

Deep learning for rapid and reproducible histology scoring of lung injury in a porcine model

Acute respiratory distress syndrome (ARDS) is a life-threatening condition with mortality rates between 30-50%. Although in vitro models replicate some aspects of ARDS, small and large animal models remain the primary research tools due to the multifactorial nature of the disease. When using these animal models, histology serves as the gold standard method to confirm lung injury and exclude other

Serum immuno-oncology markers carry independent prognostic information in patients with newly diagnosed metastatic breast cancer, from a prospective observational study

Background: Metastatic breast cancer (MBC) is a challenging disease, and despite new therapies, prognosis is still poor for a majority of patients. There is a clinical need for improved prognostication where immuno-oncology markers can provide important information. The aim of this study was to evaluate serum immuno-oncology markers in MBC patients and their respective relevance for prediction of